Peripheral Giant Cell Granuloma and Peripheral Ossifying Fibroma in Children: Two Case Reports

The gingiva is often the site of localize growth that are considered to be reactive rather than neoplastic in nature.Many of these lesions are difficult to be identified clinically and can only be identified by histological examination.Many types of localized reactive lesions occurring on the gingiva includes focal ﬁbrous hyperplasia, pyogenic granuloma, peripheral giant cell granuloma and peripheral ossifying ﬁbroma . Clinical reports of 12 and 13 year old girls with Pyogenic Granuloma and Peripheral ossifying fibroma are presented.

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Hybrid peripheral giant cell granuloma and peripheral ossifying fibroma lesion: A rare case report and review of the literature

Journal of Oral and Maxillofacial Surgery Medicine and Pathology ◽

10.1016/j.ajoms.2017.06.001 ◽

2017 ◽

Vol 29 (6) ◽

pp. 587-593

Author(s):

Mayara Santos de Castro ◽

Clenivaldo Alves Caixeta ◽

Eduardo Pereira Guimarães ◽

Alessandro Antônio Costa Pereira ◽

Felipe Fornias Sperandio ◽

...

Keyword(s):

Case Report ◽

Giant Cell ◽

Rare Case ◽

Ossifying Fibroma ◽

Giant Cell Granuloma ◽

Review Of The Literature ◽

Peripheral Ossifying Fibroma ◽

Peripheral Giant Cell Granuloma ◽

Rare Case Report

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Reactive Hyperplastic Lesions of the Gingiva: A Retrospective Study of 260 Cases

World Journal of Dentistry ◽

10.5005/jp-journals-10015-1142 ◽

2012 ◽

Vol 3 (2) ◽

pp. 126-130 ◽

Cited By ~ 4

Author(s):

Sangeetha Ramu ◽

Charlotte Rodrigues

Keyword(s):

Retrospective Study ◽

Giant Cell ◽

Pyogenic Granuloma ◽

Ossifying Fibroma ◽

Giant Cell Granuloma ◽

Multicenter Studies ◽

Age And Gender ◽

Peripheral Giant Cell Granuloma ◽

The Mean ◽

And Gender

ABSTRACT Objectives The purpose of the study was to analyze the frequency and distribution of gingival lesions in MR Ambedkar Dental College, Bengaluru. Materials and methods The material included the biopsies of all localized reactive hyperplastic lesions (LRHL) of the gingiva stored in the department's database (1995-2011). The lesions were analyzed according to their location and the patient's age and gender. The findings were compared with other published studies on reactive lesions. Results A total of 260 reactive lesion biopsies were accessed. focal fibrous hyperplasia (FFH) was the most common (38.5%), followed by pyogenic granuloma (PG) (34.6%), peripheral ossifying fibroma (POF) (17.7%) and peripheral giant cell granuloma (PGCG) (9.2%). The mean age of the patients was 33 years, with a range varying from 9 to 80 years. The LRHL occurred more commonly in females except focal fibrous hyperplasia, which showed male predilection. PG and POF were more common in the maxilla and FFH as well as PGCG were more common in the mandible. Conclusion This study indicates some differences in age and gender distribution as well as in location between the different lesions. The results of this study differ from those of other studies and the data presented here can be used as a guide for further multicenter studies. How to cite this article Ramu S, Rodrigues C. Reactive Hyperplastic Lesions of the Gingiva: A Retrospective Study of 260 Cases. World J Dent 2012;3(2):126-130.

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Angiomyolipoma of the Oral Cavity: A Rare Case Report

Journal of Dental and Maxillofacial Surgery ◽

10.18314/jdms.v2i1.1461 ◽

2019 ◽

pp. 107-110

Author(s):

Sara Amanpour ◽

Mohammad Reza Zarei ◽

Javad Faryabi ◽

Ahmad Ahrari

Keyword(s):

Oral Cavity ◽

Giant Cell ◽

Case Reports ◽

Thick Wall ◽

Giant Cell Granuloma ◽

First Case ◽

Peripheral Giant Cell Granuloma ◽

Rare Case Report ◽

Rare Benign Tumor ◽

Local Trauma

Angiomyolipoma (AML) is a rare, benign tumor composed of thick-wall blood vessels, smooth muscle component and mature adispose tissue. Differentiation from other benign and malignant mesenchymal lesions of oral cavity depends on recognition of these three histologic components, and immunohistochemical (IHC) techniques are also helpful. This tumor arise from perivascular epithelioid cells (PEComas) and kidneys followed by liver are the main locations of this soft tissue tumor. AMLs are rarely found in oral cavity and few case reports of oral AML have been reported in the literature. We report the first case of concurrent occurrence of AML of the tongue and peripheral giant cell granuloma of the gingiva in a 59-year-old patient. Clinically it was presented as a painless nodular mass with a smooth surface on the dorsal of the tongue. Based on histopathologic features and IHC staining the diagnosis of oral AML was done. The other lesion was a small sessile mass in interdental papillae of the lower incisors and microscopic examination showed the histologic features of a peripheral giant cell granuloma. Concurrent occurrence of PGCG which is a reactive mucosal hyperplasia and AML in our patient, could show the probable role of local trauma in the pathogenesis of these lesions.

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An analysis of the prevalence of peripheral giant cell granuloma and pyogenic granuloma in relation to a dental implant

BMC Oral Health ◽

10.1186/s12903-021-01566-4 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Nieves Román-Quesada ◽

Beatriz González-Navarro ◽

Keila Izquierdo-Gómez ◽

Enric Jané-Salas ◽

Antonio Marí-Roig ◽

...

Keyword(s):

Giant Cell ◽

Dental Implants ◽

Recurrence Rate ◽

Pyogenic Granuloma ◽

High Recurrence Rate ◽

Ossifying Fibroma ◽

Giant Cell Granuloma ◽

Oral Implants ◽

Time Restrictions ◽

Peripheral Giant Cell Granuloma

Abstract Background The aim of the present investigation was to evaluate the literature recurrence of peripheral giant cell granuloma and pyogenic granuloma associated with dental implants. It’s important to know the characteristics present in these lesions and possible effects on the prognosis of dental implants. Methods An electronic search without time restrictions was done in the databases: PubMed/Medline. With the keywords "Granuloma" OR "Granuloma, Giant Cell" OR "peripheral giant cell" OR "Granuloma, Pyogenic” AND "Dental implants" OR "Oral implants”. Results After applying the inclusion and exclusion criteria, a total of 20 articles were included, which reported 32 lesions (10 pyogenic granulomas, 21 peripheral giant cell granulomas and one peripheral giant cell granuloma combined with peripheral ossifying fibroma, all associated with implants). According to our review, these lesions are more frequent in males and in the posterior region of the mandible. Both excision and curettage of the lesion, compared to only excision, presented similar recurrences (40%). Explantation of the implant was performed in 41% of cases without additional recurrences. The results are not statistically significant when comparing one lesion to the other in terms of explantation (p = 0.97), recurrence (p = 0.57) or bone loss (p = 0.67). Conclusions The main therapeutic approach is tissue excision. The lesions show a high recurrence rate (34.4%), which often requires explantation of the associated implant. This recurrence rate is not affected by curettage after excision.

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Peripheral Giant Cell Granuloma: A Case Report with Review on Its Histogenesis and Recurrence

Dental Journal of Advance Studies ◽

10.1055/s-0039-1688548 ◽

2019 ◽

Vol 07 (02) ◽

pp. 095-098

Author(s):

Deepti Garg Jindal ◽

Sandhya Singh Kushwaha ◽

Sonia Joshi ◽

Namita Sepolia ◽

Varun Jindal ◽

...

Keyword(s):

Case Report ◽

Oral Cavity ◽

Giant Cell ◽

Growth Potential ◽

Biological Behavior ◽

Ossifying Fibroma ◽

Giant Cell Granuloma ◽

Cell Hyperplasia ◽

High Tendency ◽

Peripheral Giant Cell Granuloma

AbstractGiant cell granulomas (GCGs) of the jaws are non-neoplastic lesions that arise either peripherally in periodontal ligament, mucoperiosteum, or centrally in the bone. Histologically, both peripheral and central giant cell granuloma are characterized by the presence of numerous multinucleated giant cells in a prominent fibrous stroma. Peripheral giant cell granuloma is an infrequent reactive, exophytic lesion of the oral cavity, also known as giant-cell epulis, osteoclastoma, giant cell reparative granuloma, or giant cell hyperplasia. It is the most common giant cell lesion of the jaws and originates from the connective tissue of the periosteum or from the periodontal membrane, in response to local irritation or chronic trauma. The lesion develops mostly in adults, commonly in the lower jaw, with slight female predilection although is uncommon in children. Clinically, it shows resemblance to pyogenic granuloma, peripheral ossifying fibroma, and many other peripheral lesions seen in the oral cavity, but in our case it resembled a squamous cell carcinoma, thereby histopathology is mandatory for the diagnosis of this lesion. The lesion although being relatively common, still has a lot of ambiguity. The ambiguity is in terms of its etiology, growth potential, biological behavior (recurrence), histogenesis of its cells, and its treatment. The entity further holds significance because of its notorious behavior and high tendency to recur. This is a case report of a 30-year-old female patient with history of swelling in the lower anterior region of jaw since 1 year. After complete excision of lesion, lesion reoccurred after few months.

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Pyogenic Granuloma/Peripheral Giant-Cell Granuloma Associated with Implants

International Journal of Dentistry ◽

10.1155/2015/839032 ◽

2015 ◽

Vol 2015 ◽

pp. 1-9 ◽

Cited By ~ 9

Author(s):

Enric Jané-Salas ◽

Rui Albuquerque ◽

Aura Font-Muñoz ◽

Beatríz González-Navarro ◽

Albert Estrugo Devesa ◽

...

Keyword(s):

Giant Cell ◽

Successful Treatment ◽

Case Reports ◽

Pyogenic Granuloma ◽

Relevant Information ◽

Cochrane Library ◽

Giant Cell Granuloma ◽

National Library ◽

Level Of Evidence ◽

Peripheral Giant Cell Granuloma

Introduction. Pyogenic granuloma (PG) and peripheral giant-cell granuloma (PGCG) are two of the most common inflammatory lesions associated with implants; however, there is no established pathway for treatment of these conditions. This paper aims to illustrate the successful treatment of PG and PGCG and also report a systematic review of the literature regarding the various treatments proposed.Methods. To collect relevant information about previous treatments for PG and PGCG involving implants we carried out electronic searches of publications with the key words “granuloma”, “oral”, and “implants” from the last 15 years on the databases Pubmed, National Library of Medicine’s Medline, Scielo, Scopus, and Cochrane Library.Results. From the electronic search 16 case reports were found showing excision and curettage as the main successful treatment. As no clinical trials or observational studies were identified the authors agreed to present results from a review perspective.Conclusion. This is the largest analysis of PG and PGCG associated with implants published to date. Our review would suggest that PGCG associated with implants appears to have a more aggressive nature; however the level of evidence is very limited. Further cohort studies with representative sample sizes and standard outcome measures are necessary for better understanding of these conditions.

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Peripheral Ossifying Fibroma of the Posterior Maxilla: A Case Report

Journal of Health and Allied Sciences NU ◽

10.1055/s-0040-1708645 ◽

2016 ◽

Vol 06 (02) ◽

pp. 069-072

Author(s):

Mithula Nair S. ◽

Vidya Ajila ◽

Shruthi Hegde ◽

G. Subhas Babu ◽

Rumela Ghosh

Keyword(s):

Third Molar ◽

Pyogenic Granuloma ◽

Ossifying Fibroma ◽

Giant Cell Granuloma ◽

The Third ◽

Peripheral Ossifying Fibroma ◽

Peripheral Giant Cell Granuloma ◽

Posterior Maxilla ◽

Molar Region ◽

Maxillary Region

AbstractPeripheral ossifying fibroma (POF) is a reactive lesion usually arising from the interdental gingiva. The etiology is considered to be secondary to trauma or other local irritating factors. POF is almost always confused with pyogenic granuloma and peripheral giant cell granuloma. It usually shows a predominance of incidence in anterior region of maxilla and among females. Lesions are rarely larger than 2 cms in size. Incidence of peripheral ossifying fibroma in the posterior maxilla is also rare. Here we report a large peripheral ossifying fibroma occurring in a 40 year old man in the posterior maxillary region which had extended to the occlusal surface of the third molar region causing pain and erythema.

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