Pulmonary Langerhans Cell Histiocytosis Diagnosed in a Cervical Lymph Node

A 37-year-old male case was admitted with goiter. Ultrasonography of thyroid showed a 5 cm cystic nodule in the left lobe with a 1.5 cm solid component. Fine needle aspiration biopsy revealed atypia of undetermined significance or follicular lesion. The patient was operated on. The pathological diagnosis was reported as papillary thyroid carcinoma. The immunohistochemical examination showed multiple foci of Langerhans cell histiocytosis involving both lobes. The patient died due to cardiac arrest with respiratory causes in the early postoperative period. Langerhans cell histiocytosis is a rare primary condition which involves abnormal clonal proliferation of Langerhans cells in various tissues and organs. Thyroid involvement is infrequently seen. Although the etiology is unknown, genetic components may be linked to the disease. It is also associated with a family history of thyroid disease. Papillary thyroid carcinoma is the most common malignant epithelial tumor of the thyroid gland. Langerhans cell histiocytosis presenting with papillary thyroid carcinoma is rare. The privilege of our case is langerhans cell histiocytosis of the thyroid with multiple cervical lymph node involvement accompanying cervical lymph node metastatic thyroid papillary carcinoma.

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Pulmonary Langerhans cell histiocytosis with inguinal abscess: Unusual presentation

Proceedings of Singapore Healthcare ◽

10.1177/2010105819900905 ◽

2020 ◽

Vol 29 (1) ◽

pp. 64-66

Author(s):

Kamarul Naim Mohd Hirmizi ◽

Nurul Yaqeen Mohd Esa ◽

Mardiana Abdul Aziz ◽

Nor Salmah Bakar ◽

Mohammad Hanafiah

Keyword(s):

Lymph Node ◽

Langerhans Cell Histiocytosis ◽

Respiratory Symptoms ◽

Inguinal Lymph Node ◽

Langerhans Cell ◽

Histopathological Analysis ◽

Intermittent Fever ◽

Cystic Lung ◽

Pulmonary Langerhans Cell Histiocytosis ◽

History Of

We report a case of a 30-year-old man who was treated as recurrent right inguinal abscess following a 2-month history of right inguinal swelling and intermittent fever with no respiratory symptoms. Resection of his right inguinal lymph node and the histopathological analysis revealed the diagnosis of Langerhans cell histiocytosis. In addition, the CT of the thorax showed presence of bilateral cystic lung changes consistent with pulmonary Langerhans cell histiocytosis.

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Langerhans cell histiocytosis (LCH) presenting as pneumothorax and neck lymphadenopathy

Journal of Clinical Review & Case Reports ◽

10.33140/jcrc.05.01.13 ◽

2020 ◽

Vol 5 (1) ◽

Keyword(s):

Dendritic Cells ◽

Lymph Node ◽

Lung Tissue ◽

Langerhans Cell Histiocytosis ◽

Cervical Lymph Node ◽

Cervical Lymphadenopathy ◽

Lymph Node Biopsy ◽

Langerhans Cell ◽

Severe Respiratory Distress ◽

Lung Cysts

Langerhans Cell Histiocytosis (LCH) is a rare clonal disease characterized by dendritic cells infiltration in various main organs. We report a 6-month-old infant with severe respiratory distress, cervical lymphadenopathy, and reddish skin rashes on face. Diagnostic work up revealed spontaneous pneumothorax on Chest X-ray (CXR). Multiple thin-walled lung cysts and emphysema was discovered on spiral chest CT scan. Lung tissue and cervical lymph node biopsy revealed dendritic cells infiltration. Broncho alveolar lavage (BAL), cervical lymph node and lung tissue biopsy was performed and histopathology was assessed. It was suggestive of LCH with positive immunohistochemistry markers including CD1a, CD68 and S100.

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