scholarly journals Cognitive Impairment Assessment through Visuospatial Memory Can Be Performed with a Modified Walking Corsi Test Using the �Magic Carpet'

2014 ◽  
Vol 4 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Ana�ck Perrochon ◽  
Gilles Kemoun ◽  
Benoit Dugu� ◽  
Alain Berthoz
2014 ◽  
Vol 28 (1) ◽  
pp. 84-96 ◽  
Author(s):  
L. Piccardi ◽  
L. Palermo ◽  
M. Leonzi ◽  
M. Risetti ◽  
L. Zompanti ◽  
...  

2012 ◽  
Vol 34 (6) ◽  
pp. 971-978 ◽  
Author(s):  
L. Piccardi ◽  
F. Bianchini ◽  
O. Argento ◽  
A. De Nigris ◽  
A. Maialetti ◽  
...  

2021 ◽  
Vol 13 ◽  
Author(s):  
Zsuzsanna Fodor ◽  
András Horváth ◽  
Zoltán Hidasi ◽  
Alida A. Gouw ◽  
Cornelis J. Stam ◽  
...  

Background: While decreased alpha and beta-band functional connectivity (FC) and changes in network topology have been reported in Alzheimer’s disease, it is not yet entirely known whether these differences can mark cognitive decline in the early stages of the disease. Our study aimed to analyze electroencephalography (EEG) FC and network differences in the alpha and beta frequency band during visuospatial memory maintenance between Mild Cognitive Impairment (MCI) patients and healthy elderly with subjective memory complaints.Methods: Functional connectivity and network structure of 17 MCI patients and 20 control participants were studied with 128-channel EEG during a visuospatial memory task with varying memory load. FC between EEG channels was measured by amplitude envelope correlation with leakage correction (AEC-c), while network analysis was performed by applying the Minimum Spanning Tree (MST) approach, which reconstructs the critical backbone of the original network.Results: Memory load (increasing number of to-be-learned items) enhanced the mean AEC-c in the control group in both frequency bands. In contrast to that, after an initial increase, the MCI group showed significantly (p < 0.05) diminished FC in the alpha band in the highest memory load condition, while in the beta band this modulation was absent. Moreover, mean alpha and beta AEC-c correlated significantly with the size of medial temporal lobe structures in the entire sample. The network analysis revealed increased maximum degree, betweenness centrality, and degree divergence, and decreased diameter and eccentricity in the MCI group compared to the control group in both frequency bands independently of the memory load. This suggests a rerouted network in the MCI group with a more centralized topology and a more unequal traffic load distribution.Conclusion: Alpha- and beta-band FC measured by AEC-c correlates with cognitive load-related modulation, with subtle medial temporal lobe atrophy, and with the disruption of hippocampal fiber integrity in the earliest stages of cognitive decline. The more integrated network topology of the MCI group is in line with the “hub overload and failure” framework and might be part of a compensatory mechanism or a consequence of neural disinhibition.


2015 ◽  
Vol 48 ◽  
pp. 72-77 ◽  
Author(s):  
Raffaella Nori ◽  
Laura Piccardi ◽  
Matteo Migliori ◽  
Antonella Guidazzoli ◽  
Francesca Frasca ◽  
...  

2021 ◽  
Author(s):  
Nuria Martín-Pozuelo ◽  
Verónica Robles-García ◽  
Laura Piccardi ◽  
Alejandro Quintela del Rio ◽  
Javier Cudeiro ◽  
...  

2019 ◽  
Vol 215 (5) ◽  
pp. 683-690 ◽  
Author(s):  
Breda Cullen ◽  
Daniel J. Smith ◽  
Ian J. Deary ◽  
Jill P. Pell ◽  
Katherine M. Keyes ◽  
...  

BackgroundCognitive impairment is strongly linked with persistent disability in people with mood disorders, but the factors that explain cognitive impairment in this population are unclear.AimsTo estimate the total effect of (a) bipolar disorder and (b) major depression on cognitive function, and the magnitude of the effect that is explained by potentially modifiable intermediate factors.MethodCross-sectional study using baseline data from the UK Biobank cohort. Participants were categorised as having bipolar disorder (n = 2709), major depression (n = 50 975) or no mood disorder (n = 102 931 and n = 105 284). The outcomes were computerised tests of reasoning, reaction time and memory. The potential mediators were cardiometabolic disease and psychotropic medication. Analyses were informed by graphical methods and controlled for confounding using regression, propensity score-based methods and G-computation.ResultsGroup differences of small magnitude were found on a visuospatial memory test. Z-score differences for the bipolar disorder group were in the range −0.23 to −0.17 (95% CI −0.39 to −0.03) across different estimation methods, and for the major depression group they were approximately −0.07 (95% CI −0.10 to −0.03). One-quarter of the effect was mediated via psychotropic medication in the bipolar disorder group (−0.05; 95% CI −0.09 to −0.01). No evidence was found for mediation via cardiometabolic disease.ConclusionsIn a large community-based sample in middle to early old age, bipolar disorder and depression were associated with lower visuospatial memory performance, in part potentially due to psychotropic medication use. Mood disorders and their treatments will have increasing importance for population cognitive health as the proportion of older adults continues to grow.Declaration of interestI.J.D. is a UK Biobank participant. J.P.P. is a member of the UK Biobank Steering Committee.


Sign in / Sign up

Export Citation Format

Share Document