Event-Related Potentials in Response to Emotional Words in Patients with Major Depressive Disorder and Healthy Controls

Blunted reward response appears to be a trait-like marker of vulnerability for major depressive disorder (MDD). As such, it should be present in remitted individuals; however, depression is a heterogeneous syndrome. Reward-related impairments may be more pronounced in individuals with melancholic depression. The present study examined neural responses to rewards in remitted melancholic depression (rMD; n = 29), remitted nonmelancholic depression (rNMD; n = 56), and healthy controls (HC; n = 81). Event-related potentials to monetary gain and loss were recorded during a simple gambling paradigm. Relative to both the HC and the rNMD groups, who did not differ from one another, rMD was characterized by a blunted response to rewards. Moreover, the rMD and rNMD groups did not differ in course or severity of their past illnesses, or current depressive symptoms or functioning. Results suggest that blunted response to rewards may be a viable vulnerability marker for melancholic depression.

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Event-Related Potentials in Major Depressive Disorder

Journal of Korean Neuropsychiatric Association ◽

10.4306/jknpa.2019.58.2.125 ◽

2019 ◽

Vol 58 (2) ◽

pp. 125

Author(s):

Young-Min Park

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Event Related Potentials ◽

Major Depressive ◽

Related Potentials

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The Relationship Between Response-Inhibitory Event-Related Potentials and Symptoms of Attention-Deficit/Hyperactivity Disorder in Adult Patients with Major Depressive Disorder

Psychiatry Investigation ◽

10.30773/pi.2020.0074 ◽

2020 ◽

Vol 17 (10) ◽

pp. 996-1005

Author(s):

Eun Jee Kim ◽

Young Joon Kwon ◽

Hwa-Young Lee ◽

Hee-Jung Yoon ◽

Ji Sun Kim ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Attention Deficit ◽

Adult Adhd ◽

Healthy Controls ◽

Major Depressive ◽

Hyperactivity Disorder ◽

Frontal Electrode ◽

Related Potentials ◽

P3 Amplitude

Objective Attention-deficit and poor impulse control have frequently been observed in major depressive disorder (MDD) and attention-deficit and hyperactivity disorder (ADHD). Altered event-related potential (ERP) performance, such as GoNogo tasks, has been regarded as a neurocognitive process associated with attention and behavioral inhibition. The aim of this study was to investigate the association between Nogo ERP and adult ADHD in MDD.Methods A total of 64 participants with MDD (32 comorbid with ADHD) and 32 healthy controls aged 19–45 years were recruited; they performed GoNogo paradigms during electroencephalogram measurement. Beck Depression Inventory (BDI), State-Trait Anxiety Inventory (STAI), and the Adult ADHD Self-Report Scale (ASRS) were evaluated. Clinical measures and GoNogo ERP were compared between three groups: depression with ADHD, depression without ADHD, and healthy controls.Results MDD subjects with ADHD showed significantly decreased Nogo P3 amplitude at frontal electrode, compared with those without ADHD and healthy controls. MDD subjects with ADHD showed significantly longer Nogo N2 latency at frontal and frontocentral electrodes, compared with those without ADHD and healthy controls. In MDD subjects with ADHD, the Nogo P3 amplitude at the frontal electrode was negatively correlated with the ASRS score and inattention. The Nogo N2 latency at the frontal electrode was positively correlated with false alarm rate.Conclusion The decreased Nogo P3 amplitude in the frontal area might be a potential biological marker for inattention in depressed patients with ADHD.

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