Methylenetetrahydrofolate Reductase Polymorphisms and Susceptibility to Acute Lymphoblastic Leukemia in a Chinese Population: A Meta-Analysis

2014 ◽  
Vol 37 (10) ◽  
pp. 7-7 ◽  
Author(s):  
Yi Xiao ◽  
Tao-Ran Deng ◽  
Chang-Liang Su ◽  
Zhen Shang
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Chinese Population ◽  
Methylenetetrahydrofolate Reductase ◽  
Lymphoblastic Leukemia ◽  
Meta Analysis

Assessment of the relationship between methylenetetrahydrofolate reductase polymorphism and acute lymphoblastic leukemia: Evidence from an updated meta-analysis

2020 ◽  
Vol 26 (7) ◽  
pp. 1598-1610
Author(s):  
Rim Frikha
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Methylenetetrahydrofolate Reductase ◽  
Lymphoblastic Leukemia ◽  
Meta Analysis ◽  
Case Control ◽  
C677t Polymorphism ◽  
Case Control Studies ◽  
Gene Environment ◽  
Reductase Gene ◽  
The Relationship

Objective The methylenetetrahydrofolate reductase gene C677T polymorphism is closely related to the acute lymphoblastic leukemia. Several case–control studies have investigated this association; however, no conclusions could be drawn. A comprehensive updated meta-analysis is established to explain these contradictions and clarify the overall impact of this variant on the susceptibility to acute lymphoblastic leukemia. Methods Electronic searches were conducted to select published studies prior to June 2018. Pooled odds ratios and stratification analysis were performed under different genetic comparison models, age, and ethnicity. Results Totally, 66 case–control studies including 9619 acute lymphoblastic leukemia cases and 17,396 controls were selected. Our analyses showed that methylenetetrahydrofolate reductase C677T polymorphism was protective mainly in Asian and European countries, under all genetic models and regardless of age, but leukemogenic in mixed population. Conclusion Thus, C677T polymorphism may be a promising acute lymphoblastic leukemia biomarker, but they should be interpreted with caution considering other factors such as folic acid intake, gene–gene and gene–environment interactions.

scholarly journals 5,10-Methylenetetrahydrofolate Reductase Polymorphisms and Acute Lymphoblastic Leukemia Risk: A Meta-analysis

2006 ◽  
Vol 15 (10) ◽  
pp. 1956-1963 ◽  
Author(s):  
T. V. Pereira ◽  
M. Rudnicki ◽  
A. C. Pereira ◽  
M. S. Pombo-de-Oliveira ◽  
R. F. Franco
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Methylenetetrahydrofolate Reductase ◽  
Lymphoblastic Leukemia ◽  
Meta Analysis
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