Struktur-Funktions-Beziehung zwischen Frequenzverdopplungsperimetrie und optischer Kohärenztomografie beim Glaukom

Zielsetzung: Die Beurteilung des Zusammenhangs zwischen der Dicke der retinalen Nervenfaser-Schicht (retinal nerve fibre layer; RNFL) und dem Ergebnis der Frequenzverdopplungsperimetrie (FDP). Methoden: 62 gesunde Probanden und 72 Glaukompatienten wurden prospektiv ausgewählt. Alle Teilnehmer wurden einer zuverlässigen FDP und einer optischen Kohärenztomografie (optical coherence tomography; OCT) unterzogen. Pearson-Korrelationen wurden zwischen den nichtlogarithmierten Schwellenwerten der FDP und der RNFL-Dicke laut OCT berechnet. Ergebnisse: Leichte bis mittelstarke Korrelationen wurden zwischen einigen Punkten der FDP und RNFL-Dicke in der vertikalen Achse festgestellt. Der nasal superiore Bereich der FDP und die RNFL-Dicke auf der 7-Uhr-Position wiesen die stärkste Korrelation auf (0,434; p < 0,001). Schlussfolgerungen: Die geringe Übereinstimmung zwischen FDP- und OCT-Parametern deutet darauf hin, dass die beiden Messinstrumente unterschiedliche Aspekte der glaukomatösen Optikusneuropathie erfassen. Die resultierende Karte validiert zuvor berichtete klinische Befunde und trägt zu einem besseren Verständnis der Struktur-Funktions-Beziehung beim Glaukom bei. Übersetzung aus Fuertes-Lazaro I, et al: Structure-function relationship between frequency-doubling technology perimetry and optical coherence tomography in glaucoma. Ophthalmologica 2014;232:230-238 (DOI: 10.1159/000364957)

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Structure-Function Relationship between Frequency-Doubling Technology Perimetry and Optical Coherence Tomography in Glaucoma

Ophthalmologica ◽

10.1159/000364957 ◽

2014 ◽

Vol 232 (4) ◽

pp. 230-238

Author(s):

Isabel Fuertes-Lazaro ◽

Ana Sanchez-Cano ◽

Antonio Ferreras ◽

Blanca Ferrandez ◽

Pilar Calvo ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Structure Function ◽

Frequency Doubling ◽

Optical Coherence ◽

Frequency Doubling Technology ◽

Structure Function Relationship ◽

Function Relationship

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Retinal nerve fibre layer thickness measurements in childhood glaucoma: the role of scanning laser polarimetry and optical coherence tomography

Graefe s Archive for Clinical and Experimental Ophthalmology ◽

10.1007/s00417-021-05276-z ◽

2021 ◽

Author(s):

Mael Lever ◽

Christian Halfwassen ◽

Jan Darius Unterlauft ◽

Nikolaos E. Bechrakis ◽

Anke Manthey ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Nerve Fibre ◽

Retinal Nerve Fibre Layer ◽

Scanning Laser ◽

Optical Coherence ◽

Scanning Laser Polarimetry ◽

Laser Polarimetry ◽

Nerve Fibre Layer ◽

Thickness Measurements ◽

Inferior Quadrant

Abstract Purpose A central diagnostic tool in adult glaucoma is the peripapillary retinal nerve fibre layer (pRNFL) thickness. It can be assessed by scanning laser polarimetry (SLP) or optical coherence tomography (OCT). However, studies investigating the relevance of pRNFL measurements in children are rare. This study aims to compare the glaucoma diagnosing ability of SLP and OCT pRNFL thickness measurements in a paediatric population. Methods This retrospective study included 105 children (glaucoma: 22 (21.0%); healthy glaucoma suspects: 83 (79.0%)) aged 4–18 years, examined with SLP (GDxPro/ECC, Carl Zeiss Meditec) and spectral-domain OCT (SPECTRALIS®, Heidelberg Engineering). The thickness of pRNFL sectors was compared between diseased and healthy participants. Areas under the receiver-operating characteristic curves (AUC) and logistic regression results were used to compare the glaucoma discriminative capacity between SLP and OCT measurements. Results Using OCT, pRNFL thickness was decreased in the superior, nasal, and inferior quadrants of glaucoma patients compared to healthy controls (P < 0.001, each). With SLP, such a difference was only observed in the inferior quadrant (P = 0.011). A correlation between glaucoma diagnosis and OCT-measured pRNFL thickness was found in all quadrants (P < 0.001) other than the temporal. With SLP, a correlation was found for the total average thickness (P = 0.037) and inferior quadrant (P = 0.0019). Finally, the AUCs of OCT measurements were markedly higher than those of SLP (e.g., inferior quadrant: OCT 0.83, SLP 0.68). Conclusion pRNFL thickness measurements using both OCT and SLP, correlate notably with the presence of glaucoma. In general, the diagnostic performance of pRNFL thickness measurements seems higher for OCT than for SLP. Thus, pRNFL thickness measurements could provide important information, complementing conventional clinical and functional parameters in the diagnostic process of paediatric glaucoma.

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