Germ Cell Tumors in Adolescents and Young Adults

Author(s):  
Gabriele Calaminus ◽  
Jonathan Joffe
2019 ◽  
Vol 15 (8) ◽  
pp. 433-441 ◽  
Author(s):  
Adriana Fonseca ◽  
A. Lindsay Frazier ◽  
Furqan Shaikh

Germ cell tumors (GCTs) are rare in childhood, representing only 3.5% of childhood cancers, but a common malignancy in adolescents and young adults (AYAs), accounting for 13.9% of neoplasms in adolescents between age 15 and 19 years. The overall outcomes of patients treated for GCTs are excellent. However, as seen in other cancers, outcomes for AYA patients are significantly worse. Understanding the reasons for this observation has led to different approaches to diagnosis, staging, and treatment. The Malignant Germ Cell International Consortium was created to bring together pediatric, gynecologic, and testicular cancer specialists to promote research initiatives and provide evidence-based approaches in the management of GCTs across different age groups. Collaboration between multiple subspecialties is essential to further understand the disease continuum, the underlying biologic characteristics, and the development of appropriate therapeutic approaches. This review focuses on the unique characteristics of patients with extracranial GCTs in the AYA group.


2019 ◽  
Vol 143 (2) ◽  
pp. 289-296 ◽  
Author(s):  
Andrea C. Lo ◽  
Normand Laperriere ◽  
David Hodgson ◽  
Eric Bouffet ◽  
James Nicholson ◽  
...  

2018 ◽  
Vol 23 (2) ◽  
pp. 272-272
Author(s):  
Sara J. Stoneham ◽  
Juliet P. Hale ◽  
Carlos Rodriguez‐Galindo ◽  
Ha Dang ◽  
Thomas Olson ◽  
...  

2014 ◽  
Vol 19 (7) ◽  
pp. 689-692 ◽  
Author(s):  
Sara J. Stoneham ◽  
Juliet P. Hale ◽  
Carlos Rodriguez‐Galindo ◽  
Ha Dang ◽  
Thomas Olson ◽  
...  

2019 ◽  
Vol 37 (7_suppl) ◽  
pp. 521-521
Author(s):  
Maryam Soleimani ◽  
Cheryl Ho ◽  
Christian K. Kollmannsberger ◽  
Alan Bates ◽  
Bonnie Leung

521 Background: Germ cell tumours are the most common cancer of male adolescents and young adults (AYA, age 18-39). Men in this age group have been healthy much of their lives, and are at a stage of personal and professional growth, consequently a diagnosis of cancer can cause significant psychosocial distress. We evaluated patient reported psychosocial distress and hypothesized that AYA compared to older patients experienced more anxiety and distress in emotional, practical and physical domains. Methods: All patients referred to BC Cancer complete the Psychosocial Screen for Cancer (PSSCAN-R) at first consultation. This is a validated screening questionnaire for distress. Components include a screen for subclinical/clinical symptoms of depression and anxiety and the Canadian Problem Checklist (CPC) with 6 domains of concern: emotional, informational, practical, spiritual, social/family and physical. Results: Data was collected for 349 patients from 2011-2015. Baseline characteristics: 227 (65%) AYA, median age 33 (range 18-83), 41 (11%) metastatic disease at diagnosis. The top 3 AYA concerns were work/school (38.3%), financial (34.8%), frustration and anger (26%). AYA patients scored positive for subclinical/clinical anxiety more commonly than their older counterparts (39.4% vs. 27.9%, p = 0.028). AYA patients with subclinical/clinical anxiety symptoms experienced more fears and worries (41.5%), concerns regarding work/school (38%), lack of understanding of their disease (37.9%), finances (35.3%) and frustration and anger (26.3%) than AYA patients who do not express anxiety symptoms. Conclusions: The results of this study indicate that AYA with testicular cancer have unique needs and experience significantly more self-reported anxiety symptoms with emotional, informational, and practical concerns. Programs tailored to address needs of AYA patients may help reduce anxiety and improve the cancer experience. The results of this study are valuable to stakeholders for allocation of resources to address psychosocial parameters of distress in this patient group.


Author(s):  
Andrea Lo ◽  
Normand Laperriere ◽  
David Hodgson ◽  
Eric Bouffet ◽  
James Nicholson ◽  
...  

2020 ◽  
Vol 149 (3) ◽  
pp. 523-532
Author(s):  
Jordan Wong ◽  
Karen Goddard ◽  
Normand Laperriere ◽  
Jennifer Dang ◽  
Eric Bouffet ◽  
...  

2019 ◽  
Vol 3 (s1) ◽  
pp. 141-142
Author(s):  
Amy Moskop ◽  
Julie Panepinto ◽  
Sadie Dobrozsi

OBJECTIVES/SPECIFIC AIMS: Objectives: To examine the differences in health outcomes of adolescents and young adults treated for malignancy at a pediatric cancer center compared to an adult cancer center. To determine the differences in receipt of supportive care for adolescents and young adults with malignancy who are treated at a pediatric cancer center compared to an adult cancer center. METHODS/STUDY POPULATION: Methods: This will be a retrospective cohort study of patients from the ages of 15 to 39 years who are diagnosed with a malignancy common between adult and pediatric facilities within 2013-2017. Data will be abstracted from an existing database at MCW containing patient information at the adult and pediatric centers. Study population: Patients ages 15-39 years of age who are categorized as young adolescent and adult patients (AYAs). Patients are eligible for the cohort if they have a diagnosis that is common between adult and pediatric oncology centers and that is made within the years 2013-2017. These diagnoses will include ALL, AML, Hodgkin Lymphoma, Non-Hodgkin Lymphoma, Germ cell tumors, Osteosarcoma, Ewing Sarcoma, other sarcomas, and CNS tumors. RESULTS/ANTICIPATED RESULTS: There will be a difference in health care utilization, clinical trial enrollment and toxicity of therapy in AYAs with malignancies treated at an adult facility than AYAs treated for similar malignancy at pediatric facility. DISCUSSION/SIGNIFICANCE OF IMPACT: There will be a difference in receipt of supportive care referrals, including psychology, social work, sperm banking, initiation of palliative care, in AYAs treated at a pediatric facility compared to AYAs treated at adult facility.


2017 ◽  
Vol 19 (suppl_6) ◽  
pp. vi212-vi213
Author(s):  
Andrea Lo ◽  
Normand Laperriere ◽  
David Hodgson ◽  
Eric Bouffet ◽  
James Nicholson ◽  
...  

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