scholarly journals RARE-06. CANADIAN PATTERNS OF PRACTICE FOR INTRACRANIAL GERM CELL TUMOURS IN ADOLESCENTS AND YOUNG ADULTS

2017 ◽  
Vol 19 (suppl_6) ◽  
pp. vi212-vi213
Author(s):  
Andrea Lo ◽  
Normand Laperriere ◽  
David Hodgson ◽  
Eric Bouffet ◽  
James Nicholson ◽  
...  
2019 ◽  
Vol 143 (2) ◽  
pp. 289-296 ◽  
Author(s):  
Andrea C. Lo ◽  
Normand Laperriere ◽  
David Hodgson ◽  
Eric Bouffet ◽  
James Nicholson ◽  
...  

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e13629-e13629
Author(s):  
Wei Lin Goh ◽  
Jiancheng Hong ◽  
Evelyn Wong ◽  
Victoria Wong ◽  
Daniel Quah ◽  
...  

e13629 Background: Cancer in adolescents and young adults (AYAOs) refers to patients diagnosed with a malignancy between 16 and 39 years old. This is thought to be 5% in the Western population. The exact incidence and distribution in Asia is uncertain although the WHO estimated 650 000 AYAs to be newly diagnosed in this part of the world in 2018. There is limited data on the incidence and epidemiology on AYAs in Asia, but it is known from the western literature that the distribution of cancer types, clinico-pathological features and outcomes in this population is very different. We therefore, sought to evaluate the pattern of cancer types among the different age groups of the AYA population seen in a high-volume single Asian tertiary cancer centre. Methods: We undertook a retrospective observational study of all patients diagnosed with cancer between 16 and 39 years old who presented to the National Cancer Centre Singapore (NCCS) from 1 January 2015 to 31 December 2019. Results: A total of 2583 cases was observed during the 5-year period. The male: female ratio was 1:1.75. The majority of the patients were between of 35-39 years (y) ( n= 1128, 44.0%). The most common cancer across the different age groups in females were sarcoma (16-19 y), hematologic malignancies (20-24 y) and breast cancer (25-29 y, 30-34 y and 35-39 y). The most common cancer across the different age groups in males were hematologic malignancies (16-19 y), germ cell tumours (20-24 y), germ cell tumours, hematologic malignancies and sarcoma (25-29 y), hematologic malignancies (30-34 y) and colorectal cancers (35-39 y). The majority of the patients presented were localized disease (38.3%), while 19.4% presented with lymphatic involvement. Amongst 507 (19.6%) patients presenting with metastatic disease, 126 patients have deceased. Conclusions: This population has unique characteristics compared to their geriatric and pediatric counterparts. With an increased incidence and expected longer survivals, more efforts are needed to better understand the clinicopathological features of the AYA population. This will enable us to better survival rates and long-term treatment outcomes.


Author(s):  
Andrea Lo ◽  
Normand Laperriere ◽  
David Hodgson ◽  
Eric Bouffet ◽  
James Nicholson ◽  
...  

2020 ◽  
Vol 149 (3) ◽  
pp. 523-532
Author(s):  
Jordan Wong ◽  
Karen Goddard ◽  
Normand Laperriere ◽  
Jennifer Dang ◽  
Eric Bouffet ◽  
...  

2019 ◽  
Vol 15 (8) ◽  
pp. 433-441 ◽  
Author(s):  
Adriana Fonseca ◽  
A. Lindsay Frazier ◽  
Furqan Shaikh

Germ cell tumors (GCTs) are rare in childhood, representing only 3.5% of childhood cancers, but a common malignancy in adolescents and young adults (AYAs), accounting for 13.9% of neoplasms in adolescents between age 15 and 19 years. The overall outcomes of patients treated for GCTs are excellent. However, as seen in other cancers, outcomes for AYA patients are significantly worse. Understanding the reasons for this observation has led to different approaches to diagnosis, staging, and treatment. The Malignant Germ Cell International Consortium was created to bring together pediatric, gynecologic, and testicular cancer specialists to promote research initiatives and provide evidence-based approaches in the management of GCTs across different age groups. Collaboration between multiple subspecialties is essential to further understand the disease continuum, the underlying biologic characteristics, and the development of appropriate therapeutic approaches. This review focuses on the unique characteristics of patients with extracranial GCTs in the AYA group.


2018 ◽  
Vol 23 (2) ◽  
pp. 272-272
Author(s):  
Sara J. Stoneham ◽  
Juliet P. Hale ◽  
Carlos Rodriguez‐Galindo ◽  
Ha Dang ◽  
Thomas Olson ◽  
...  

2014 ◽  
Vol 19 (7) ◽  
pp. 689-692 ◽  
Author(s):  
Sara J. Stoneham ◽  
Juliet P. Hale ◽  
Carlos Rodriguez‐Galindo ◽  
Ha Dang ◽  
Thomas Olson ◽  
...  

2011 ◽  
Vol 3 (4) ◽  
pp. 201 ◽  
Author(s):  
Matthew J. Murray ◽  
Lorna A. Fern ◽  
Daniel P. Stark ◽  
Tim O. Eden ◽  
James C. Nicholson

Teenagers and young adults (TYA) with cancer have complex and evolving needs which are unique to this patient group. The TYA age-group have outcomes that are not improving over time, lagging behind both adult and children’s cancers in their rate of improvement in recent years...


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