Lipofilling: A New Therapeutic Option for the Treatment of Lupus Panniculitis-Induced Atrophy

Lupus panniculitis is a rare manifestation of cutaneous lupus erythematosus, which may lead to major aesthetic sequelae with a severe impact on patients’ quality of life. We report 2 cases supporting the short- and long-term efficacy and safety of lipofilling in the treatment of lupus panniculitis-induced atrophy. These observations pave the way for prospective, larger-scale studies in patients with scarring lupus panniculitis, provided that the autoimmune pathogenic process is in complete, stable remission.

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Outcomes of interventional electrophysiology in children under 2 years of age

Cardiology in the Young ◽

10.1017/s1047951111001971 ◽

2011 ◽

Vol 22 (5) ◽

pp. 499-506 ◽

Cited By ~ 8

Author(s):

Christian J. Turner ◽

Kai C. Lau ◽

Gary F. Sholler

Keyword(s):

Therapeutic Option ◽

Early Recurrence ◽

Efficacy And Safety ◽

Older Children ◽

Pharmacological Agents ◽

Interventional Electrophysiology ◽

Short And Long Term ◽

Few Data ◽

Repeat Procedures

AbstractBackgroundDespite the increasing utilisation of interventional electrophysiology in adults and older children with arrhythmias, there are few data reflecting the safety and efficacy of this procedure in the age group under 2 years.AimWe describe our experience in assessing the efficacy and safety with this group of children.MethodsWe undertook a retrospective review of all infants under 2 years of age who underwent an interventional electrophysiology procedure between 1995 and 2009 to determine indications, procedural details, short- and long-term success, and complication rate.ResultsA total of 23 interventional electrophysiology procedures were performed in 17 patients initially under 2 years of age. Of these, three patients had congenital heart disease. The most common indication was arrhythmia resistant to pharmacological agents (59%), with the remaining cases being arrhythmia complicated by cardiovascular instability (41%). There was initial success in 15 patients after the first procedure, with early recurrence in four. Following six repeat procedures, there was long-term success in 15 patients (88%), with three repeat procedures being performed after 2 years of age. There was one non-procedural death related to persisting arrhythmia. There were three minor complications. In one patient, cryotherapy was used successfully.ConclusionsThe interventional electrophysiology procedure is a viable therapeutic option in infants under 2 years with arrhythmia resistant to other conventional medical management.

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Long-term efficacy and safety outcomes of lenalidomide for cutaneous lupus erythematosus: a multicenter retrospective observational study of 40 patients

Journal of the American Academy of Dermatology ◽

10.1016/j.jaad.2020.11.014 ◽

2020 ◽

Author(s):

Raphael Aitmehdi ◽

Laurent Arnaud ◽

Camille Francès ◽

Patricia Senet ◽

Jean-Benoît Monfort ◽

...

Keyword(s):

Observational Study ◽

Lupus Erythematosus ◽

Cutaneous Lupus Erythematosus ◽

Retrospective Observational Study ◽

Efficacy And Safety ◽

Term Efficacy ◽

Safety Outcomes ◽

Cutaneous Lupus

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New Era in Atopic Dermatitis Treatment: Results of Long-Term Dupilumab Administration

Вопросы современной педиатрии ◽

10.15690/vsp.v20i5.2312 ◽

2021 ◽

Vol 20 (5) ◽

pp. 390-395

Author(s):

Nikolay N. Murashkin ◽

Leonid A. Opryatin ◽

Roman V. Epishev ◽

Alexander I. Materikin ◽

Eduard T. Ambarchyan ◽

...

Keyword(s):

Atopic Dermatitis ◽

Skin Inflammation ◽

Efficacy And Safety ◽

Barrier Dysfunction ◽

Treatment Results ◽

New Era ◽

Short And Long Term ◽

Chronic Skin

Atopic dermatitis (AD) is a disease characterized by chronic skin inflammation and epidermal barrier dysfunction leading to decrease in patients' quality of life. AD is widespread in general population including children. This article covers the disease pathophysiological mechanisms including those that depend on the endotype, as well as core principles of systemic therapy for children with moderate and severe AD. Features of targeted therapy of such patients with dupilumab (IL-4 and IL-13 inhibitor) are presented. The studies' results on dupilumab efficacy and safety in the short- and long-term are shown.

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QUALITY OF LIFE PROBLEMS OF GYNECOLOGICAL CANCER PATIENTS

Problems in oncology ◽

10.37469/0507-3758-2017-63-3-368-374 ◽

2017 ◽

Vol 63 (3) ◽

pp. 368-374

Author(s):

Olga Churuksaeva ◽

Larisa Kolomiets

Keyword(s):

Quality Of Life ◽

Gynecological Cancer ◽

Social Aspects ◽

Cancer Data ◽

Life Problems ◽

Anticancer Treatment ◽

Short And Long Term ◽

The Relationship

Due to improvements in short- and long-term clinical outcomes a study of quality of life is one of the most promising trends in oncology today. This review analyzes the published literature on problems dealing with quality of life of patients with gynecological cancer. Data on quality of life with respect to the extent of anticancer treatment as well as psychological and social aspects are presented. The relationship between quality of life and survival has been estimated.

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