Masood’s and Modified Masood’s Scoring Index: An Evaluation of Fine Needle Aspiration Cytology of Breast Lesions with Histopathological Correlation

2019 ◽  
Vol 63 (3) ◽  
pp. 233-239
Author(s):  
Charu Agarwal ◽  
Varsha Chauhan ◽  
Mukta Pujani ◽  
Kanika Singh ◽  
Sujata Raychaudhari ◽  
...  
Keyword(s):  
Positive Predictive Value ◽  
Diagnostic Accuracy ◽  
Fine Needle Aspiration ◽  
Predictive Value ◽  
Needle Aspiration ◽  
Breast Lesions ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology ◽  
Scoring Index

Objective: As fine needle aspiration cytology (FNAC) is the primary tool for evaluation of breast lesions, it is essential to segregate lesions with low and high risk of malignancy. To address this, Masood proposed a cytological scoring system for categorization, Masood’s Scoring Index (MSI), which was modified later (Modified Masood’s Scoring Index [MMSI]). This study analyses the effectiveness of MMSI over MSI and assesses the concordance between cytological scoring and histopathology. Study Design: All breast FNACs over a period of 2 years were categorized based on MSI and MMSI by 2 reviewers independently. The agreement rate along with specificity, sensitivity, positive predictive value, negative predictive value and diagnostic accuracy were calculated. Correlation and concordance analyses between cytological and histopathological categories were conducted. Results and Discussion: Out of 415 cases of breast FNACs, histopathology was available for 310 for which MSI and MMSI were evaluated. The sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy were 95, 100, 100, 97.6 and 98.3%, respectively. The difference between the concordance rate of MSI and of MMSI for various cytological categories was found to be statistically significant. Conclusion: MMSI has a better concordance with histopathological diagnosis than MSI. MMSI can serve as a uniform standardized scoring system for breast cytology for better categorization of proliferative breast diseases.

scholarly journals Diagnostic utility of fine needle aspiration cytology in thyroid lesions

2020 ◽  
Vol 8 (7) ◽  
pp. 2628
Author(s):  
Farzana Manzoor ◽  
Arif R. Sheikh ◽  
Bilal A. Sheikh
Keyword(s):  
Diagnostic Accuracy ◽  
Fine Needle Aspiration ◽  
Predictive Value ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Non Invasive ◽  
Needle Aspiration Cytology ◽  
Thyroid Lesions

Background: Thyroid fine needle aspiration cytology (FNAC) is an important screening tool and thereby dictates clinical management. The exclusion of non-invasive follicular variant of papillary carcinoma (NIFVPTC) from thyroid malignancies and its reclassification as non-malignant entity i.e., non-invasive follicular thyroid neoplasm with papillary like nuclear features (NIFTP) has added a new dimension. Aim of this study was to study the role of fine needle aspiration cytology in screening thyroid lesions by correlation with histopathological examination and to calculate diagnostic accuracy of FNAC considering NIFTP as non-malignant and compare it with pre NIFTP era.Methods: It was an observational study done over a period of 2 years (2017-2018). It included the cases where FNAC was followed subsequently by histopathology. FNAC results were correlated with histopathological diagnosis established thereof.Results: A total of 107 patients were included in this study. Considering NIFTP as non-malignant, sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy were 92.97%, 100%, 100%, 92.73% and 96.23% respectively, that is significantly higher if authors considered NIFTP as malignant.Conclusions: FNAC plays an indispensable role in making preliminary diagnosis in thyroid lesions. There is a notable increase in diagnostic accuracy of FNAC in thyroid lesions and significant decrease in risk of malignancy by considering NIFTP as non-malignant.

scholarly journals Ultrasound and guided fine needle aspiration cytology in the submandibular triangle

1997 ◽  
Vol 2 (3) ◽  
pp. 8-13
Author(s):  
A. T. Ahuja ◽  
W. T. Yang ◽  
W. King ◽  
C. Metreweli
Keyword(s):  
Positive Predictive Value ◽  
Negative Predictive Value ◽  
Fine Needle Aspiration ◽  
Predictive Value ◽  
Fine Needle Aspiration Cytology ◽  
Relevant Information ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology

Objective: The aim of this study was to evaluate whether High Resolution Ultrasound (US) along with Fine Needle Aspiration Cytology (FNAC) can provide the surgeon with adequate preoperative information for masses in the submandibular triangle.Subjects and methods: Eighty-two consecutive patients with suspected masses of the submandibular triangle had US with guided FNAC (49 patients) and final histological correlation (47 patients).Results: Compared to final histology, US had a sensitivity of 97%, specificity 83%, positive predictive value 91% and a negative predictive value of 95% while FNAC had sensitivity of 100%, specificity 90%, positive predictive value 94% and negative predictive value of 100%.Conclusion: US combined with a FNAC is an ideal initial investigation for evaluating masses in submandibular area.  It is quick, inexpensive, easily available, and provides the surgeon with relevant information preoperatively obviating the need for further expensive imaging.

Fine-Needle Aspiration Cytology (FNAC) is a reliable diagnostic tool for small breast lesions (≤ 1.0 cm): a 20-year retrospective study

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Jessica Aline Tomelin de Cursi ◽  
Mariângela Esther Alencar Marques ◽  
Cristina Andrea Campos de Assis Cunha Castro ◽  
Fernando Carlos Schmitt ◽  
Cleverson Teixeira Soares
Keyword(s):  
Fine Needle Aspiration ◽  
Predictive Value ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Breast Lesions ◽  
Major Public Health Problem ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Small Breast ◽  
Needle Aspiration Cytology

Abstract Background Breast cancer is a major public health problem worldwide. It is recommended that small breast lesions or those suspicious for malignancy be evaluated via histopathological examination (“core biopsy” or surgical specimens), and lesions that are probably benign and palpable should be examined via fine-needle aspiration cytology (FNAC). This study aimed to assess the accuracy of FNAC for the diagnosis of small breast lesions. Methods We reviewed all anatomopathological reports of FNACs collected between January 1, 2000 and December 31, 2019 (n = 24,721) in a private community pathology service. Lesions up to 1.0 cm (≤1.0 cm) (n = 8334) were included for evaluation and classified according to the recommendation of the International Academy of Cytology Yokohama System for Reporting Breast Fine Needle Aspiration Biopsy Cytopathology in the following categories: (1) insufficient/inadequate; (2) benign; (3) atypical, probably benign; (4) suspicious of malignancy; and (5) malignant. Subsequently, the results of the FNACs were compared to those of the respective histopathological examinations (n = 785). Results FNAC had a specificity of 99.6%; sensitivity, 97.4%; positive predictive value, 99.6%; negative predictive value, 97.6%; and accuracy, 98.5%. Conclusions FNAC is a reliable method for diagnosing small breast lesions (≤1.0 cm).

scholarly journals Diagnostic utility of fine needle aspiration cytology in salivary gland lesions: a teaching institutional experience

2019 ◽  
Vol 6 (11) ◽  
pp. 3955 ◽  
Author(s):  
Shilpa M. Shetty ◽  
Kusuma K. N.
Keyword(s):  
Salivary Gland ◽  
Diagnostic Accuracy ◽  
Fine Needle Aspiration ◽  
Predictive Value ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology ◽  
Sensitivity Specificity

Background: Fine needle aspiration cytology (FNAC) is being widely used for pre-operative diagnosis of salivary gland lesions. It is a simple, cost effective and safe procedure that provides valuable information for planning appropriate management. The aim was to study cytohistopathological correlation of salivary gland lesions; to examine sensitivity, specificity and diagnostic accuracy of fine needle aspiration cytology of salivary gland lesions.Methods: A 4 year 8 months study was conducted from January 2015 to August 2019. Salivary gland lesion FNAC performed in the Department of Pathology, SIMS, Shimoga who were followed up with corresponding biopsy specimen were included in the study.Results: Total of 42 cases was included in the study. Pleomorphic adenoma was the commonest lesion encountered. The overall sensitivity, specificity, diagnostic accuracy, positive predictive value and negative predictive value was 50%, 97.22%, 90.47%, 75% and 92.10%. Diagnostic pit falls occurred because of sampling error and overlapping morphological features.Conclusions: Fine needle aspiration (FNA) though poses diagnostic dilemma in some cases, it still forms an easy and less invasive procedure that can assess therapeutic management of salivary gland lesions.

scholarly journals Original Article. Diagnostic Value of Tru-Cut Biopsy in Diagnosing Breast Lesions

2016 ◽  
Vol 9 (2) ◽  
pp. 126-129
Author(s):  
Dobromir D. Dimitrov ◽  
Martin P. Karamanliev ◽  
Tashko S. Deliyski ◽  
Anislav V. Gabarski ◽  
Petar P. Vatov ◽  
...  
Keyword(s):  
Fine Needle Aspiration ◽  
Predictive Value ◽  
Fine Needle Aspiration Cytology ◽  
Diagnostic Value ◽  
Needle Aspiration ◽  
Breast Lesions ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Retrospective Clinical Study ◽  
Needle Aspiration Cytology

SummaryBreast cancer is the most common cancer in women worldwide. The standard for detecting it includes clinical exam, mammography and fine-needle aspiration cytology. Our aim was to establish the role of the tru-cut biopsy in the diagnosis of malignant breast lesions. We provideatwo-year retrospective clinical study defining 98.67%sensitivity, 100%specificity, 100%positive predictive value, 80%negative predictive value and an overall diagnostic accuracy of 98.73%. In 89.1%of the malignant lesions, the sample was adequate to define the receptor status. Therefore, tru-cut biopsy is an easy, cheap, safe and accurate alternative to fine-needle aspiration cytology in the diagnosis of breast lesions.

Fine-Needle Aspiration Cytology versus Core-Needle Biopsy for Breast Lesions: A Dilemma of Superiority between the Two

2021 ◽  
pp. 1-6
Author(s):  
Priyanka Verma ◽  
Reetika Sharma ◽  
Neelam Sharma ◽  
Anchana Gulati ◽  
Anupam Parashar ◽  
...  
Keyword(s):  
Fine Needle Aspiration ◽  
Core Needle Biopsy ◽  
Predictive Value ◽  
Needle Biopsy ◽  
Needle Aspiration ◽  
Breast Lesions ◽  
Aspiration Cytology ◽  
Core Needle ◽  
Fine Needle ◽  
Needle Aspiration Cytology

<b><i>Introduction:</i></b> Core-needle biopsy (CNB) is a minimally invasive procedure used in preoperative diagnosis of breast lumps. It has been seen that in few years, the CNB seems to be replacing the fine-needle aspiration cytology (FNAC), although no study had yet conclusively proved a superiority of one over the other. <b><i>Aims and Objectives:</i></b> The aim of this study was to study the cytohistological spectrum of palpable breast lesions and to evaluate the diagnostic accuracy of FNAC versus CNB for breast lesions. <b><i>Materials and Methods:</i></b> The study was a cross-sectional study conducted in the Department of Pathology and Surgery, over a period of 1 year in 152 patients. All the patients were subjected to FNAC and CNB. Cytosmears were stained with May-Grunwald Giemsa and hematoxylin and eosin was done on CNB and excision biopsy (EB) specimens. Sensitivity and specificity were calculated in percentage with 95% confidence interval with reference to CNB/surgical specimens. Kappa statistics were used to compare the level of agreement between FNAC versus CNB and CNB versus surgical specimens. <b><i>Results:</i></b> A total of 152 patients were taken for FNAC and CNB. EB was performed in only 104 patients. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of FNAC verses CNB in correlation with subsequent histopathology were found to be (93.40 vs. 94.06%), (97.50 vs. 100.00%), (99.00 vs. 100.00%), (84.78 vs. 33.33%), and (94.52 vs. 94.23%), respectively. <b><i>Conclusion:</i></b> CNB has overcome the pitfall of FNAC but CNB cannot replace FNAC but both procedures are complementary to each other.

scholarly journals ASSESSMENT OF DIAGNOSTIC ACCURACY OF FINE NEEDLE ASPIRATION CYTOLOGY IN BENIGN AND MALIGNANT BREAST LESIONS

2020 ◽  
Vol 4 (3) ◽  
Author(s):  
Tanwi Singh ◽  
Kalpana Chandra
Keyword(s):  
Diagnostic Accuracy ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Large Population ◽  
Needle Aspiration ◽  
Breast Lesions ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Malignant Breast ◽  
Needle Aspiration Cytology

Increasing awareness, associated anxiety & stress among women who perceive every lump in breast as carcinoma, compels the patient to seek the medical advice. It is sometimes difficult to determine whether a suspicious lump is benign or malignant simply from clinical assessment and fine needle aspiration cytology (FNAC) is helpful in reaching definitive diagnosis. Accuracy in the diagnosis can be increased by multiple sampling of appropriate sites by ultrasonography guidance and/or mammographic localization. Breast cancer is the most common cancer in women all over India. Due to lack of awareness and almost non-existent breast screening practices, patients present with palpable breast cancers. Hence based on above findings the present study was planned for Assessment of Diagnostic Accuracy of Fine Needle Aspiration Cytology in Benign and Malignant Breast Lesions. The present study was planned in Department of Pathology, Indira Gandhi Institute of Medical Science, Patna, Bihar, India. The present study was planned from duration of march 2019 to August 2019. In the present study 50 females with breast lesion were included and evaluated in the present study. The FNAC was performed in each patient by the technique of Martin and Ellis using 21-22G needle attached to 20 ml disposable syringe and smear prepared both wet fixed in 95% ethanol and air dried. All cytology smears were stained by May Grunwald Giemsa, Papanicolaou, and hematoxylin and eosin stain. It is highly useful in screening large population as it is simple, rapid, cost effective and reliable. FNAC has few limitations and biopsy is must in cases with suspicious and atypical lumps. FNAC serves as a compliment and not a substitute to the histopathology in such cases. So, it is concluded that FNAC should be used as a routine diagnostic procedure to maximize the availability of effective health care to patients with breast lesions. Keywords: Diagnostic Accuracy, Fine Needle Aspiration, Cytology, Benign, Malignant Breast Lesions, etc.

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