scholarly journals Novel Face-Name Paired Associate Learning and Famous Face Recognition in Mild Cognitive Impairment: A Neuropsychological and Brain Volumetric Study

2019 ◽  
Vol 9 (1) ◽  
pp. 114-128
Author(s):  
Satyan Nanda ◽  
Nandini Mohanan ◽  
Sheela Kumari ◽  
Mridula Mathew ◽  
Sushama Ramachandran ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Face Recognition ◽  
Mild Cognitive Impairment ◽  
Free Recall ◽  
Associative Learning ◽  
Paired Associate ◽  
Early Stage ◽  
Paired Associate Learning ◽  
Associate Learning ◽  
Association Learning

Purpose: To assess visual associative learning and famous face recognition ability among subjects with stable amnestic mild cognitive impairment (MCI) relative to early stage dementia due to Alzheimer’s disease (AD) and cognitively normal healthy controls (NC) and to correlate these differences with volumetric changes on MRI. Methods: A hospital-based cross-sectional observational study was conducted on 61 participants. The subjects underwent neuropsychological evaluation, including validated newly designed tests for novel face-name paired association learning recall and famous face recognition. MRI volumetry was done on a subset of patients to ascertain the topographical patterns of volume loss. Results: There were significant differences in performance on free recall for face-name paired associate learning in MCI (n = 22) compared to NC (n = 20) (p < 0.001) and MCI compared to AD (n = 19; p < 0.001). Significant differences were also noted in scores on the famous personalities test between MCI and NC (p = 0.007), and MCI and AD (p = 0.032). The free recall component of face-name pair associative learning significantly correlated with left cuneus (p = 0.005; r = 0.833) and right cuneus (p = 0.003; r = 0.861) volume in AD with no significant correlation among MCI and NC cohorts. Conclusions: Novel and semantically familiar face-name associative recalls are significantly impaired in MCI, and these potentially predate the MRI volumetric changes in MCI. Our findings expand the spectrum of recall deficits in MCI.

P3-193: Stability of amnestic mild cognitive impairment: Cantab paired associate learning as a predictor of a consistent diagnosis

2015 ◽  
Vol 11 (7S_Part_15) ◽  
pp. P706-P706
Author(s):  
Francesca K. Cormack ◽  
Jennifer H. Barnett ◽  
Pradeep Nathan ◽  
Andrew Blackwell ◽  
Shannon Z. Klekociuk ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Paired Associate ◽  
Paired Associate Learning ◽  
Amnestic Mild Cognitive Impairment ◽  
Associate Learning

Examining the nature of impairment in visual paired associate learning in amnestic mild cognitive impairment.

2011 ◽  
Vol 25 (6) ◽  
pp. 752-762 ◽  
Author(s):  
Brian T. Harel ◽  
David Darby ◽  
Robert H. Pietrzak ◽  
Kathryn A. Ellis ◽  
Peter J. Snyder ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Paired Associate ◽  
Paired Associate Learning ◽  
Amnestic Mild Cognitive Impairment ◽  
Associate Learning

scholarly journals Children’s paired-associate learning: Response and associative learning as a function of similarity

1974 ◽  
Vol 3 (5) ◽  
pp. 327-329
Author(s):  
Robert L. Solso ◽  
John H. Mueller ◽  
Rosario C. Pesce ◽  
George Weiss
Keyword(s):  
Associative Learning ◽  
Paired Associate ◽  
Paired Associate Learning ◽  
Associate Learning

Verbal Fluency, Free Recall, and Paired-Associate Learning Speed

1965 ◽  
Vol 16 (2) ◽  
pp. 659-660
Author(s):  
James G. Greeno
Keyword(s):  
Free Recall ◽  
Verbal Fluency ◽  
Paired Associate ◽  
Word List ◽  
Paired Associate Learning ◽  
Associate Learning ◽  
Verbal Skills ◽  
Learning Speed ◽  
List Learning ◽  
Positive Correlations

This study investigated the relation between performance in paired-associate learning and other verbal skills (verbal fluency to word and nonsense stimuli, recall of a word list). Ss learned two lists of word-CVC pairs. Significant positive correlations were found between fluency measures and learning of both lists. Recall scores were similarly correlated with second-list, but not first-list, learning.

scholarly journals Touchscreen-based location discrimination and paired associate learning tasks detect cognitive impairment at an early stage in an App knock-in mouse model of Alzheimer’s disease

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Md. Ali Bin Saifullah ◽  
Okiru Komine ◽  
Yutao Dong ◽  
Kazuya Fukumoto ◽  
Akira Sobue ◽  
...  
Keyword(s):  
Mouse Model ◽  
Cognitive Decline ◽  
Neurofibrillary Tangles ◽  
Water Maze ◽  
Paired Associate ◽  
Early Stage ◽  
Paired Associate Learning ◽  
Morris Water Maze Test ◽  
Associate Learning ◽  
Maze Test

AbstractAlzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline with accumulation of amyloid beta (Aβ) and neurofibrillary tangles that usually begins 15–30 years before clinical diagnosis. Rodent models that recapitulate aggressive Aβ and/or the pathology of neurofibrillary tangles are essential for AD research. Accordingly, non-invasive early detection systems in these animal models are required to evaluate the phenotypic changes, elucidate the mechanism of disease progression, and facilitate development of novel therapeutic approaches. Although many behavioral tests efficiently reveal cognitive impairments at the later stage of the disease in AD models, it has been challenging to detect such impairments at the early stage. To address this issue, we subjected 4–6-month-old male AppNL−G−F/NL−G−F knock-in (App-KI) mice to touchscreen-based location discrimination (LD), different object–location paired-associate learning (dPAL), and reversal learning tests, and compared the results with those of the classical Morris water maze test. These tests are mainly dependent on the brain regions prone to Aβ accumulation at the earliest stages of the disease. At 4–6 months, considered to represent the early stage of disease when mice exhibit initial deposition of Aβ and slight gliosis, the classical Morris water maze test revealed no difference between groups, whereas touchscreen-based LD and dPAL tasks revealed significant impairments in task performance. Our report is the first to confirm that a systematic touchscreen-based behavioral test battery can sensitively detect the early stage of cognitive decline in an AD-linked App-KI mouse model. This system could be applied in future translational research.

Role of Rules in Paired-Associate Learning

1979 ◽  
Vol 44 (2) ◽  
pp. 648-650 ◽  
Author(s):  
May F. D'amato ◽  
Mark Diamond
Keyword(s):  
Free Recall ◽  
Paired Associate ◽  
Paired Associate Learning ◽  
Associate Learning ◽  
Unmixed List ◽  
Middle Letter

14 students in each of four groups learned a single unmixed list of 19 CVC pairs for 12 anticipation trials followed by a free recall of the pairs. In three of the four lists a single rule applied to all of the pairs. The rule was that the words in each pair changed first letter (rhymed), changed middle letter, or changed last letter. A fourth list contained only pairs of unrelated words. Mean number of correct anticipations per trial showed rhyming and end-change rules to be equally beneficial, although not as effective as the middle-change rule. Free recall of the pairs showed no differences among lists. Results were interpreted as supporting the hypothesis that rules facilitate retrieval by restricting the number of responses to be considered for each stimulus.

Sign in / Sign up

Export Citation Format

Share Document