Comparison of Six Different Allergen Extracts for Subcutaneous Specific Immunotherapy in Children: An Open-Labelled, Prospective, Controlled Observational Trial

2019 ◽  
Vol 180 (4) ◽  
pp. 284-290
Author(s):  
Matthias Volkmar Kopp ◽  
Inke R. König ◽  
Frank Friedrichs ◽  
Hans Ulrich Umpfenbach ◽  
Bodo Niggemann ◽  
...  
Keyword(s):  
Specific Immunotherapy ◽  
Observational Trial ◽  
Allergen Extracts ◽  
Subcutaneous Specific Immunotherapy

Absolute Quantification of Allergens from Complex Mixtures: A New Sensitive Tool for Standardization of Allergen Extracts for Specific Immunotherapy

2011 ◽  
Vol 10 (4) ◽  
pp. 2113-2122 ◽  
Author(s):  
Ulla Seppälä ◽  
Claire Dauly ◽  
Sarah Robinson ◽  
Martin Hornshaw ◽  
Jørgen Nedergaard Larsen ◽  
...  
Keyword(s):  
Specific Immunotherapy ◽  
Absolute Quantification ◽  
Complex Mixtures ◽  
Sensitive Tool ◽  
Allergen Extracts

Perspectives in Allergen-Specific Immunotherapy: Molecular Evolution of Peptide- and Protein-Based Strategies

2020 ◽  
Vol 21 (2) ◽  
pp. 203-223 ◽  
Author(s):  
Alain Jacquet
Keyword(s):  
Specific Immunotherapy ◽  
Patient Adherence ◽  
Recombinant Allergen ◽  
Preclinical Studies ◽  
Allergen Specific Immunotherapy ◽  
Adverse Side Effects ◽  
Long Duration ◽  
Tremendous Progress ◽  
Allergen Extracts

Allergen-specific Immunotherapy (AIT), through repetitive subcutaneous or sublingual administrations of allergen extracts, represents up to now the unique treatment against allergic sensitizations. However, the clinical efficacy of AIT can be largely dependent on the quality of natural allergen extracts. Moreover, the long duration and adverse side effects associated with AIT negatively impact patient adherence. Tremendous progress in the field of molecular allergology has made possible the design of safer, shorter and more effective new immunotherapeutic approaches based on purified and characterized natural or recombinant allergen derivatives and peptides. This review will summarize the characteristics of these different innovative vaccines including their effects in preclinical studies and clinical trials.

scholarly journals Persistence and evolution of allergen-specific IgE repertoires during subcutaneous specific immunotherapy

2016 ◽  
Vol 137 (5) ◽  
pp. 1535-1544 ◽  
Author(s):  
Mattias Levin ◽  
Jasmine J. King ◽  
Jacob Glanville ◽  
Katherine J.L. Jackson ◽  
Timothy J. Looney ◽  
...  
Keyword(s):  
Specific Immunotherapy ◽  
Specific Ige ◽  
Subcutaneous Specific Immunotherapy
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