Isolated Ocular Sarcoidosis Mimicking Ring Melanoma

We report the case of a 25-year-old female, who presented with a large, pale tumor of her ciliary body that extended to >180° of the anterior chamber angle. All preoperative examinations including ultrasound biomicroscopy, scleral transillumination, and MRI indicated melanoma. A thorough systemic work-up was negative. A diagnosis of ring melanoma was suspected, and the patient was scheduled for enucleation. However, perioperative frozen section indicated granulomatous inflammation. The enucleation was cancelled, and a subtenon injection of triamcinolone was administered, which resulted in the disappearance of the tumor. Together, the findings meet the criteria for the diagnosis of isolated ocular sarcoidosis. This case demonstrates that a sarcoid granuloma can mimic all clinical features of a ring melanoma. Therefore, a biopsy should be done before destructive surgery is carried out.

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Ultrasound biomicroscopy study of ciliary body and its influence on anterior chamber angle width

Acta Ophthalmologica Scandinavica ◽

10.1111/j.1600-0420.1997.tb00460.x ◽

2009 ◽

Vol 75 (S224) ◽

pp. 27-28 ◽

Cited By ~ 1

Author(s):

G. Marchini ◽

A. Toscano ◽

R. Tosi ◽

M. Marraffa ◽

L. Bonomi

Keyword(s):

Anterior Chamber ◽

Ciliary Body ◽

Ultrasound Biomicroscopy ◽

Anterior Chamber Angle ◽

Angle Width ◽

Chamber Angle

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Locally Invasive Diffuse Iris Ring Melanoma Presenting as Unilateral Severe Glaucoma: Case Report and Review of Molecular Genetics

Case Reports in Oncology ◽

10.1159/000512012 ◽

2021 ◽

pp. 403-410

Author(s):

Mina M. Naguib ◽

Patricia Chévez-Barrios ◽

Silvia Orengo-Nania ◽

Amy C. Schefler

Keyword(s):

Molecular Genetics ◽

Histopathological Examination ◽

Clinical History ◽

Ultrasound Biomicroscopy ◽

Molecular Signature ◽

Anterior Chamber Angle ◽

Mixed Cell ◽

Ring Melanoma ◽

Aggressive Clinical Course ◽

Very High

We report the clinical history and histopathological findings in a case of diffuse iris ring melanoma (DIM) and review the most recent literature and modern molecular genetics of this entity. An 85-year-old Hispanic man presented with severe unilateral glaucoma, managed at an outside institution for 2 years prior to presentation. Diffuse pigmentation was noted in the angle, on the intraocular lens implant, and in the vitreous without clear demonstration of a mass on ultrasound biomicroscopy. Workup for metastatic cutaneous melanoma was negative. Histopathological examination of the enucleated eye revealed a mixed cell type iris ring melanoma with diffuse intraocular involvement. Gene expression profiling (GEP) revealed a class 2 molecular signature indicating a very high risk for metastases. Unilateral glaucoma presenting with marked pigmentation in the anterior chamber angle should be managed as melanoma until proven otherwise. Iris ring melanomas are known to have an aggressive clinical course, and recent molecular analyses indicate that they are likely primarily GEP class 2 with a very poor prognosis, similar to the majority of ciliary body melanomas.

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Selective laser trabeculoplasty induced changes in the thickness of ciliary body and iris evaluated by ultrasound biomicroscopy

Graefe s Archive for Clinical and Experimental Ophthalmology ◽

10.1007/s00417-010-1572-x ◽

2010 ◽

Vol 249 (6) ◽

pp. 887-894 ◽

Cited By ~ 1

Author(s):

Umit Aykan ◽

Ilhami Salcan ◽

Ozlem Yildirim ◽

Dilaver Ersanli

Keyword(s):

Ciliary Body ◽

Ultrasound Biomicroscopy ◽

Selective Laser Trabeculoplasty ◽

Laser Trabeculoplasty ◽

Induced Changes

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A case report of ultrasonographic findings in bilateral diffuse Uveal melanocytic proliferation

BMC Ophthalmology ◽

10.1186/s12886-020-01720-6 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Jingli Guo ◽

Wenyi Tang ◽

Wei Liu ◽

Min Zhou ◽

Qing Chang ◽

...

Keyword(s):

Case Report ◽

Retinal Detachment ◽

High Frequency ◽

Ciliary Body ◽

Case Series ◽

Ultrasound Biomicroscopy ◽

The Other ◽

Exudative Retinal Detachment ◽

Case Presentation ◽

Choroidal Nevi

Abstract Background To report undescribed characteristics of patients with bilateral diffuse uveal melanocytic proliferation (BDUMP) on ultrasound biomicroscopy (UBM) and high-frequency B-scan ultrasonography. Case presentation Two of four participants presented with worsening bilateral vision after previously diagnosed primary pulmonary or ovarian carcinoma. The other two patients were diagnosed with lung carcinoma after presentation with BDUMP. All patients had ciliary body nevi-like lesion in combination with iris or ciliary body cysts, and uveal thickening on UBM. Focally elevated choroidal nevi-like lesion and exudative retinal detachment with choroidal thickening were detected with B-scan ultrasonography. Conclusions Our case series demonstrates the uveal characteristics of patients with BDUMP based on high-frequency B-scan ultrasonography and UBM. Ultrasonographic findings are crucial in the diagnosis of BDUMP because it is occult in nature.

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Morphometric assessment of normal human ciliary body using ultrasound biomicroscopy

Graefe s Archive for Clinical and Experimental Ophthalmology ◽

10.1007/s00417-017-3809-4 ◽

2017 ◽

Vol 255 (12) ◽

pp. 2437-2442 ◽

Cited By ~ 4

Author(s):

Yoshifumi Okamoto ◽

Fumiki Okamoto ◽

Shinichiro Nakano ◽

Tetsuro Oshika

Keyword(s):

Ciliary Body ◽

Ultrasound Biomicroscopy ◽

Normal Human ◽

Morphometric Assessment

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Management of dislocated nucleus with corneal opacity by combined deep anterior lamellar keratoplasty, pars- plana vitrectomy and phaco-fragmentation

BMJ Case Reports ◽

10.1136/bcr-2019-229397 ◽

2019 ◽

Vol 12 (6) ◽

pp. e229397

Author(s):

Samendra Karkhur ◽

Alok Sen ◽

Gautam Parmar ◽

Priyavrat Bhatia

Keyword(s):

Ciliary Body ◽

Surgical Intervention ◽

Corneal Opacity ◽

Ultrasound Biomicroscopy ◽

Lamellar Keratoplasty ◽

Deep Anterior Lamellar Keratoplasty ◽

Anterior Lamellar Keratoplasty ◽

Ciliary Processes ◽

Pars Plana ◽

The Right

A 32-year-old man presented with bilateral diminution of vision for 10 years. Visual acuity was light perception in both eyes with inaccurate projection in the oculus dextrus(OD) and accurate projection in the in oculus sinister (OS). Intraocular pressure was 6 and 12 mm Hg in the OD and OS, respectively. Slit-lamp examination revealed the presence of leucomatous corneal opacification with microcornea in oculus uterque (OU). Both eyes had a dislocated nucleus in the vitreous cavity on ultrasound B-scan with advanced cupping in the right eye. Ultrasound biomicroscopy revealed ciliary body atrophy in the OD and preserved ciliary processes (two quadrants) in the OS. In view of a partially preserved ciliary body function and a potential for gaining useful vision, we planned surgical intervention in the left eye. Deep anterior lamellar keratoplasty with pars planavitrectomy (PPV) and phacofragmentation of the nucleus was done. Donor lamellar graft was sutured after completion of PPV and nucleus fragmentation. The patient regained useful ambulatory vision postoperatively with clear corneal graft.

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Trabeculectomy in an unsuspected extramedullary iris–ciliary body plasmacytoma

European Journal of Ophthalmology ◽

10.1177/1120672120920225 ◽

2020 ◽

pp. 112067212092022

Author(s):

Harathy Selvan ◽

Seema Kashyap ◽

Seema Sen ◽

Bhavna Chawla ◽

Neiwete Lomi ◽

...

Keyword(s):

Ciliary Body ◽

Histopathological Examination ◽

Neovascular Glaucoma ◽

Ultrasound Biomicroscopy ◽

Extramedullary Plasmacytoma ◽

Plasma Cell Dyscrasia ◽

Post Operative Period ◽

Bleb Failure ◽

Disease Free

Extramedullary plasmacytoma of the iris and ciliary body is extremely rare. We present a case which was misdiagnosed as granulomatous uveitis with neovascular glaucoma, and underwent a trabeculectomy with mitomycin-c along with iris biopsy. The post-operative period showed early bleb failure and catastrophic growth of the suspected mass. Histopathological examination revealed a diagnosis iris plasmacytoma. Subsequent ultrasound biomicroscopy showed involvement of the iris and ciliary body. A prompt systemic workup was done, and an associated systemic plasma cell dyscrasia was ruled out. The affected eye was enucleated, and the patient remains disease free at the end of 3-year follow-up.

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