scholarly journals Association between the Onset of Idiopathic Normal Pressure Hydrocephalus Symptoms and Reduced Default Mode Network Connectivity

2020 ◽  
Vol 49 (3) ◽  
pp. 255-263
Author(s):  
Koichi Miyazaki ◽  
Kohei Hanaoka ◽  
Hayato Kaida ◽  
Yasutaka Chiba ◽  
Kazunari Ishii
Keyword(s):  
Normal Pressure Hydrocephalus ◽  
Default Mode Network ◽  
Fdg Pet ◽  
Normal Pressure ◽  
Idiopathic Normal Pressure Hydrocephalus ◽  
Whole Body ◽  
Default Mode ◽  
Pet Ct ◽  
The Mean ◽  
Fdg Pet Ct

<b><i>Objective:</i></b> The aim was to examine the association between connectivity changes in the default mode network (DMN) and the progression of idiopathic normal pressure hydrocephalus (iNPH). <b><i>Methods:</i></b> We retrospectively recruited cases of preclinical and clinical iNPH from 2,196 patients who had received whole-body <sup>18</sup>F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) scanning. We included 31 cases with asymptomatic ventriculomegaly with features of iNPH on MRI (AVIM; reported as preclinical iNPH) and 12 with iNPH. We performed a voxel-based analysis of the brain FDG-PET images of the AVIM and iNPH groups as well as for each background-matched normal control (NC) group, using Statistical Parametric Mapping 12. Volume of interest (VOI)-based analysis was also performed. We set the VOI as the region from the precuneus to the posterior cingulate cortices (PCC), and compared the mean regional standardized uptake value ratio (SUVR) between the AVIM and iNPH group FDG-PET/CT images and each corresponding NC group. <b><i>Results:</i></b> The voxel-based analysis showed a greater decreased FDG uptake in the PCC in the iNPH group than in the AVIM group. The VOI-based analysis revealed no significant difference in the mean SUVR of the AVIM group and the corresponding NC group, but that of the iNPH group was significantly lower than that of its corresponding NC group. <b><i>Conclusions:</i></b> DMN connectivity was reduced in the clinical iNPH group but not in the preclinical group. These data suggest that alterations in the functional connectivity of the DMN are related to the onset of iNPH symptoms.

scholarly journals 18F-FDG PET-CT pattern in idiopathic normal pressure hydrocephalus

2018 ◽  
Vol 18 ◽  
pp. 897-902 ◽  
Author(s):  
Ryan A. Townley ◽  
Hugo Botha ◽  
Jonathan Graff-Radford ◽  
Bradley F. Boeve ◽  
Ronald C. Petersen ◽  
...  
Keyword(s):  
Normal Pressure Hydrocephalus ◽  
Fdg Pet ◽  
Normal Pressure ◽  
Idiopathic Normal Pressure Hydrocephalus ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

[P1-384]: A NOVEL 18F-FDG PET-CT PATTERN IN IDIOPATHIC NORMAL PRESSURE HYDROCEPHALUS

2017 ◽  
Vol 13 (7S_Part_8) ◽  
pp. P413-P413
Author(s):  
Ryan A. Townley ◽  
Hugo Botha ◽  
Jonathan Graff-Radford ◽  
Bradley F. Boeve ◽  
Matthew L. Senjem ◽  
...  
Keyword(s):  
Normal Pressure Hydrocephalus ◽  
Fdg Pet ◽  
Normal Pressure ◽  
Idiopathic Normal Pressure Hydrocephalus ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals Default mode network connectivity in patients with idiopathic normal pressure hydrocephalus

2016 ◽  
Vol 124 (2) ◽  
pp. 350-358 ◽  
Author(s):  
Hui Ming Khoo ◽  
Haruhiko Kishima ◽  
Naoki Tani ◽  
Satoru Oshino ◽  
Tomoyuki Maruo ◽  
...  
Keyword(s):  
Normal Pressure Hydrocephalus ◽  
Default Mode Network ◽  
Resting State ◽  
Clinical Symptoms ◽  
Region Of Interest ◽  
Normal Pressure ◽  
Idiopathic Normal Pressure Hydrocephalus ◽  
Urinary Continence ◽  
Resting State Functional Connectivity ◽  
Default Mode

OBJECT Idiopathic normal pressure hydrocephalus (iNPH) is a neurological disorder characterized by gait disturbance, cognitive impairment, and incontinence. It is unclear whether the pathophysiology of iNPH is associated with alterations in the default mode network (DMN). The authors investigated alterations in the DMN of patients with iNPH and sought to determine whether a relationship exists between the resting-state functional connectivity of the DMN and a patient’s clinical symptoms. METHODS Resting-state functional MRI (rs-fMRI) was performed in 16 preoperative patients with iNPH and 15 neurologically healthy control subjects of a similar age. Independent component and dual-regression analyses were used to quantify DMN connectivity. The patients’ clinical symptoms were rated according to the iNPH grading scale (iNPHGS). Each of their specific clinical symptoms were rated according to the cognitive, gait, and urinary continence domains of iNPHGS, and neurocognitive status was assessed using the Mini-Mental State Examination, Frontal Assessment Battery (FAB), and Trail Making Test Part A. The strength of DMN connectivity was compared between patients and controls, and the correlation between DMN connectivity and iNPHGS was examined using both region of interest (ROI)-based analysis and voxel-based analysis. The correlation between DMN connectivity and each of the specific clinical symptoms, as well as neurocognitive status, was examined using voxel-based analysis. RESULTS Both ROI-based and voxel-based analyses revealed reduced DMN connectivity in patients with iNPH. ROI-based analysis showed increased DMN connectivity with worsening clinical symptoms of iNPH. Consistently, voxel-based analyses revealed that DMN connectivity correlated positively with the iNPHGS score, as well as the cognitive and urinary continence domain scores, and negatively with the FAB score. The significant peak in correlation in each case was localized to the precuneus. CONCLUSIONS This is the first study to establish alterations in the DMN of patients with iNPH. DMN connectivity may be a useful indicator of the severity of clinical symptoms in patients with iNPH.

scholarly journals An Australian local diagnostic reference level for paediatric whole-body 18F-FDG PET/CT

2019 ◽  
Vol 92 (1096) ◽  
pp. 20180879
Author(s):  
Essam Mohammed Alkhybari ◽  
Mark F. McEntee ◽  
Kathy P. Willowson ◽  
Patrick C. Brennan ◽  
Theo Kitsos ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Whole Body ◽  
Reference Level ◽  
Diagnostic Reference Level ◽  
Weight Category ◽  
Pet Ct ◽  
The Mean ◽  
Fdg Pet Ct ◽  
Administered Activity ◽  
Age Category

Objective: The aim of this study is to report a local diagnostic reference level (DRL) for paediatric whole-body (WB) fludeoxyglucose (18F-FDG) positron emission tomography (PET) CT examinations. Methods: The Australian Radiation Protection and Nuclear Safety Agency (ARPANSA) national DRL (NDRL) age category (0–4 years and 5–14 years), the International Commission on Radiological Protection age category (ICRP age) (<1, >1–5, >5–10, and >10–15 years), and European guideline weight category ( EG weight) (<5, 5–<15, 15–<30, 30–<50, and 50–<80 kg) were used to determine a local DRL for WB 18F FDG PET/CT studies. Two-structured questionnaires were designed to collect dose data, patient demographics, equipment details, and acquisition protocols for WB 18F-FDG PET/CT procedures. The local DRL was based on the median 18F-FDG administered activity (MBq), dose–length product (DLP), and the CT dose index volume (CTDIvol), values. The effective dose (E) was also calculated and reported. Results: The local DRLs for 18F-FDG administered activity, CTDIvol and DLP values based on ARPANSA age and ICRP age were increased from lower to higher age categories. For the EG weight category, the local DRL for 18F-FDG administered activity, CTDIvol and DLP values were increased from the low EG weight category to the high EG weight category. The mean administered activity in our study based on ICRP age category >1–5, >5–10, and >10–15 years is 79.97, 119.40, and 176.04 MBq, which is lower than the mean administered activity reported in the North American Consensus guideline published in 2010 (99, 166, and 286 MBq) and European Association of Nuclear Medicine and Dosage Card (version 1.5.2008) (120, 189, and 302 MBq). However, the mean administered activity in our study based on ICRP age category <1 year was 55 MBq compared to the EANM Dosage card (version 1.5.2008) (70 MBq) and the NACG 2010 (51 MBq). Our study shows that the finding for ICRP age category <1 year was similar to the NACG 2010 value. Conclusion: The determined local DRL values for the radiation doses associated with WB 18F FDG PET/CT examinations are differed considerably between the ARPANSA and ICRP age category and EG weight category. Although, the determined 18F-FDG value for ICRP < 1 year is in good agreement with available publish data, it is preferable to optimise the 18F-FDG administered activity while preserving the diagnostic image quality. Advances in knowledge: The local DRL value determined from WB 18F-FDG PET/CT examinations may help to establish the ARPANSA NDRL for WB FDG 18F-PET/CT examinations.

scholarly journals Multi-task weak supervision enables anatomically-resolved abnormality detection in whole-body FDG-PET/CT

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Sabri Eyuboglu ◽  
Geoffrey Angus ◽  
Bhavik N. Patel ◽  
Anuj Pareek ◽  
Guido Davidzon ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Location Estimation ◽  
Supervised Machine Learning ◽  
Whole Body ◽  
Free Text ◽  
Abnormality Detection ◽  
Weak Supervision ◽  
Radiology Reports ◽  
Pet Ct ◽  
Fdg Pet Ct

AbstractComputational decision support systems could provide clinical value in whole-body FDG-PET/CT workflows. However, limited availability of labeled data combined with the large size of PET/CT imaging exams make it challenging to apply existing supervised machine learning systems. Leveraging recent advancements in natural language processing, we describe a weak supervision framework that extracts imperfect, yet highly granular, regional abnormality labels from free-text radiology reports. Our framework automatically labels each region in a custom ontology of anatomical regions, providing a structured profile of the pathologies in each imaging exam. Using these generated labels, we then train an attention-based, multi-task CNN architecture to detect and estimate the location of abnormalities in whole-body scans. We demonstrate empirically that our multi-task representation is critical for strong performance on rare abnormalities with limited training data. The representation also contributes to more accurate mortality prediction from imaging data, suggesting the potential utility of our framework beyond abnormality detection and location estimation.

Evaluation of 18 F-FDG PET/MRI, 18 F-FDG PET/CT, MRI, and CT in whole-body staging of recurrent breast cancer

2016 ◽  
Vol 85 (2) ◽  
pp. 459-465 ◽  
Author(s):  
Lino M. Sawicki ◽  
Johannes Grueneisen ◽  
Benedikt M. Schaarschmidt ◽  
Christian Buchbender ◽  
James Nagarajah ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fdg Pet ◽  
Recurrent Breast Cancer ◽  
Whole Body ◽  
Pet Ct ◽  
Recurrent Breast ◽  
Fdg Pet Ct

scholarly journals Traumatic myositis ossificans: multifocal lesions suggesting malignancy on FDG-PET/CT—a case report

2020 ◽  
Vol 50 (1) ◽  
pp. 249-254
Author(s):  
Miho Sasaki ◽  
Yuka Hotokezaka ◽  
Reiko Ideguchi ◽  
Masataka Uetani ◽  
Shuichi Fujita
Keyword(s):  
Case Report ◽  
Fdg Pet ◽  
Myositis Ossificans ◽  
Whole Body ◽  
Left Cheek ◽  
Multiple Fractures ◽  
Fdg Uptake ◽  
Pet Ct ◽  
Multiple Regions ◽  
Fdg Pet Ct

AbstractMyositis ossificans (MO) is a benign soft-tissue lesion characterized by the heterotopic formation of the bone in skeletal muscles, usually due to trauma. MO is occasionally difficult to diagnose because of its clinical and radiological similarities with malignancy. We report a case of traumatic MO (TMO) in the masseter and brachial muscles of a 37-year-old man who presented with painless swelling in the left cheek and severe trismus. Due to the absence of a traumatic history at the first consultation and identification of a tumorous lesion in the left masseter muscle by magnetic resonance imaging (MRI), the lesion was suspected to be a malignant tumor. Subsequently, 18F-fluorodeoxyglucose positron-emission tomography/computed tomography (FDG-PET/CT) showed multiple regions of high FDG uptake across the whole body, suggestive of multiple metastases or other systemic diseases. However, intramuscular calcifications were also observed in the left masseter and brachial muscles, overlapping the areas with high FDG uptake. Moreover, multiple fractures were seen in the rib and lumbar spine, also overlapping the areas with high FDG uptake. Based on these imaging findings, along with a history of jet-ski trauma, TMO was suspected. The left cheek mass was surgically excised and histologically diagnosed as TMO. In this case report, FDG-PET/CT could detect multiple TMOs across the whole body. To the best of our knowledge, cases of multiple TMOs located far apart in different muscles are rare, and this may be the first report.

Low positive yield from routine inclusion of the brain in whole-body 18F-FDG PET/CT imaging for noncerebral malignancies

2013 ◽  
Vol 34 (6) ◽  
pp. 540-543 ◽  
Author(s):  
Kuruva Manohar ◽  
Anish Bhattacharya ◽  
Bhagwant R. Mittal
Keyword(s):  
Fdg Pet ◽  
Ct Imaging ◽  
Whole Body ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
The Brain

scholarly journals Comparison of the diagnostic performance and impact on management of 18F-FDG PET/CT and whole-body MRI in multiple myeloma

2021 ◽  
Author(s):  
Olwen Westerland ◽  
◽  
Ashik Amlani ◽  
Christian Kelly-Morland ◽  
Michal Fraczek ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Clinical Data ◽  
Bone Disease ◽  
Fdg Pet ◽  
Diagnostic Performance ◽  
Whole Body ◽  
Bone Lesions ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

Abstract Purpose Comparative data on the impact of imaging on management is lacking for multiple myeloma. This study compared the diagnostic performance and impact on management of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) and whole-body magnetic resonance imaging (WBMRI) in treatment-naive myeloma. Methods Forty-six patients undergoing 18F-FDG PET/CT and WBMRI were reviewed by a nuclear medicine physician and radiologist, respectively, for the presence of myeloma bone disease. Blinded clinical and imaging data were reviewed by two haematologists in consensus and management recorded following clinical data ± 18F-FDG PET/CT or WBMRI. Bone disease was defined using International Myeloma Working Group (IMWG) criteria and a clinical reference standard. Per-patient sensitivity for lesion detection was established. McNemar test compared management based on clinical assessment ± 18F-FDG PET/CT or WBMRI. Results Sensitivity for bone lesions was 69.6% (32/46) for 18F-FDG PET/CT (54.3% (25/46) for PET component alone) and 91.3% (42/46) for WBMRI. 27/46 (58.7%) of cases were concordant. In 19/46 patients (41.3%) WBMRI detected more focal bone lesions than 18F-FDG PET/CT. Based on clinical data alone, 32/46 (69.6%) patients would have been treated. Addition of 18F-FDG PET/CT to clinical data increased this to 40/46 (87.0%) patients (p = 0.02); and WBMRI to clinical data to 43/46 (93.5%) patients (p = 0.002). The difference in treatment decisions was not statistically significant between 18F-FDG PET/CT and WBMRI (p = 0.08). Conclusion Compared to 18F-FDG PET/CT, WBMRI had a higher per patient sensitivity for bone disease. However, treatment decisions were not statistically different and either modality would be appropriate in initial staging, depending on local availability and expertise.

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