scholarly journals Hepatitis E virus capsid as a carrier of exogenous antigens for the development of chimeric virus-like particles

Intervirology ◽  
2021 ◽  
Author(s):  
Tianyu Lu ◽  
Nouredine Behloul ◽  
Yi Zhou ◽  
Sarra Baha ◽  
Zhenzhen Liu ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Chimeric Virus ◽  
Virus Capsid ◽  
Virus Like Particles

scholarly journals Hepatitis E virus capsid as a carrier of exogenous antigens for the development of chimeric virus-like particles

2020 ◽  
Author(s):  
Tianyu Lu ◽  
Nouredine BEHLOUL ◽  
Sarra BAHA ◽  
Yi Zhou ◽  
Zhenzhen Liu ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Chimeric Virus ◽  
Virus Capsid ◽  
Virus Like Particles

Generation in yeast and antigenic characterization of hepatitis E virus capsid protein virus-like particles

2017 ◽  
Vol 102 (1) ◽  
pp. 185-198 ◽  
Author(s):  
Martynas Simanavicius ◽  
Paulius Lukas Tamosiunas ◽  
Rasa Petraityte-Burneikiene ◽  
Reimar Johne ◽  
Rainer G. Ulrich ◽  
...  
Keyword(s):  
Capsid Protein ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Virus Capsid ◽  
Virus Like Particles ◽  
Antigenic Characterization ◽  
Virus Capsid Protein

scholarly journals Efficient Production of Chimeric Hepatitis B Virus-Like Particles Bearing an Epitope of Hepatitis E Virus Capsid by Transient Expression in Nicotiana benthamiana

Life ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 64
Author(s):  
Gergana Zahmanova ◽  
Milena Mazalovska ◽  
Katerina Takova ◽  
Valentina Toneva ◽  
Ivan Minkov ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Nicotiana Benthamiana ◽  
Hepatitis E Virus ◽  
Chimeric Protein ◽  
Hepatitis E ◽  
Core Antigen ◽  
Efficient Production ◽  
Virus Like Particles ◽  
B Virus

The core antigen of hepatitis B virus (HBcAg) is capable of self-assembly into virus-like particles (VLPs) when expressed in a number of heterologous systems. Such VLPs are potential carriers of foreign antigenic sequences for vaccine design. In this study, we evaluated the production of chimeric HBcAg VLPs presenting a foreign epitope on their surface, the 551–607 amino acids (aa) immunological epitope of the ORF2 capsid protein of hepatitis E virus. A chimeric construct was made by the insertion of 56 aa into the immunodominant loop of the HBcAg. The sequences encoding the chimera were inserted into the pEAQ-HT vector and infiltrated into Nicotiana benthamiana leaves. The plant-expressed chimeric HBcHEV ORF2 551–607 protein was recognized by an anti-HBcAg mAb and anti-HEV IgG positive swine serum. Electron microscopy showed that plant-produced chimeric protein spontaneously assembled into “knobbly” ~34 nm diameter VLPs. This study shows that HBcAg is a promising carrier platform for the neutralizing epitopes of hepatitis E virus (HEV) and the chimeric HBcAg/HEV VLPs could be a candidate for a bivalent vaccine.

scholarly journals Induction of antibody and interferon-γ production in mice immunized with virus-like particles of swine hepatitis E virus

2014 ◽  
Vol 15 (4) ◽  
pp. 575 ◽  
Author(s):  
Young-Jo Song ◽  
Woo-Jung Park ◽  
Seul-Kee Lee ◽  
Joong-Bok Lee ◽  
Seung-Yong Park ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Interferon Γ ◽  
Virus Like Particles ◽  
Swine Hepatitis

scholarly journals Chimeric Recombinant Hepatitis E Virus-like Particles as an Oral Vaccine Vehicle Presenting Foreign Epitopes

Virology ◽  
2002 ◽  
Vol 293 (2) ◽  
pp. 273-280 ◽  
Author(s):  
Masahiro Niikura ◽  
Shiki Takamura ◽  
Gisen Kim ◽  
Satoru Kawai ◽  
Masayuki Saijo ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Oral Vaccine ◽  
Hepatitis E ◽  
Recombinant Hepatitis ◽  
Virus Like Particles

scholarly journals Biological and immunological characteristics of hepatitis E virus-like particles based on the crystal structure

2009 ◽  
Vol 106 (31) ◽  
pp. 12986-12991 ◽  
Author(s):  
T. Yamashita ◽  
Y. Mori ◽  
N. Miyazaki ◽  
R. H. Cheng ◽  
M. Yoshimura ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Virus Like Particles

Generation of hepatitis E virus-like particles of two new genotypes G5 and G6 and comparison of antigenic properties with those of known genotypes

2015 ◽  
Vol 178 (1-2) ◽  
pp. 150-157 ◽  
Author(s):  
Tian-Cheng Li ◽  
Michiyo Kataoka ◽  
Kazuaki Takahashi ◽  
Sayaka Yoshizaki ◽  
Takanobu Kato ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Virus Like Particles ◽  
Antigenic Properties

scholarly journals Liver-specific Gene Delivery Using Engineered Virus-Like Particles of Hepatitis E Virus

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Eun Byul Lee ◽  
Jung-Hee Kim ◽  
Wonhee Hur ◽  
Jung Eun Choi ◽  
Sung Min Kim ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Specific Gene ◽  
Virus Like Particles
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