Increased Monocyte Chemotactic Protein-1 Accompanying Pro-Inflammatory Processes are Associated with Progressive Hearing Impairment and Bilateral Disability of Meniere’s Disease

2021 ◽  
pp. 1-9
Author(s):  
Ryota Iinuma ◽  
Hiroshi Okuda ◽  
Natsuko Obara ◽  
Yoshitaka Matsubara ◽  
Mitsuhiro Aoki ◽  
...  
Keyword(s):  
Hearing Impairment ◽  
Meniere’S Disease ◽  
Meniere's Disease ◽  
Ménière’S Disease ◽  
Menière's Disease ◽  
Control Subjects ◽  
Monocyte Chemotactic Protein ◽  
Chemotactic Protein ◽  
Inflammatory Processes ◽  
Ménière's Disease

<b><i>Background:</i></b> The progression of hearing impairment and the bilateral involvement of Meniere’s disease (MD) may depend on the disease duration and aging. Recent studies reported that MD might involve dysfunction of the microvascular circulation damaged due to inflammatory changes. <b><i>Objectives:</i></b> The aim of this study was to determine that the progress of the MD’s hearing impairment and bilateral disability may be associated with the pathogenesis of several pro-inflammatory processes. <b><i>Patients and Methods:</i></b> We recruited 30 unilateral MD patients (56.8 ± 14.7 years old), 7 bilateral MD patients (65.3 ± 13.9 years old), and 17 age-matched control subjects (53.5 ± 14.4 years old, <i>p</i> &#x3e; 0.05). We measured the plasma vascular endothelial growth factor (VEGF), plasma interleukin-6 (IL-6), plasma tumor-necrosis factor α (TNFα), and plasma monocyte chemotactic protein-1 (MCP-1). <b><i>Results:</i></b> The bilateral MD group and the unilateral MD group had higher plasma MCP-1 (204.7 ± 41.0 pg/mL and 169.5 ± 32.0 pg/mL) than the control group (149.2 ± 30.7 pg/mL) (<i>p</i> &#x3c; 0.05). There was no significant difference in plasma TNFα, IL-6, and VEGF among 3 groups (<i>p</i> &#x3e; 0.05). There was a strong correlation between the plasma MCP-1 and age in MD patients (<i>r</i> = 0.58, <i>p</i> &#x3c; 0.01); however, no significant correlation between the plasma MCP-1 and age was found in control subjects (<i>p</i> &#x3e; 0.05). The plasma MCP-1 significantly correlated with the average hearing level of 500, 1,000, 2,000, and 4,000 Hz, and the maximum slow phase eye velocity in caloric test in the better side (<i>p</i> &#x3c; 0.05). Also, the plasma MCP-1 showed significant positive correlations with the plasma IL-6 (<i>r</i> = 0.49, <i>p</i> &#x3c; 0.01) and plasma TNFα (<i>r</i> = 0.32, <i>p</i> &#x3c; 0.05) in MD group. <b><i>Conclusions:</i></b> Our results suggest that the increased plasma MCP-1 accompanying pro-inflammatory processes are associated with the progression of the hearing impairment and the bilateral disability of MD.

scholarly journals Progression of hearing impairment in Meniere's disease

1988 ◽  
Vol 47 (Suppl-4) ◽  
pp. 111-114
Author(s):  
Tosie Sakurai ◽  
Yosiaki Nakai ◽  
Hideo Yamane ◽  
Kazuo Konisi
Keyword(s):  
Hearing Impairment ◽  
Meniere’S Disease ◽  
Menière’S Disease ◽  
Meniere's Disease ◽  
Ménière’S Disease ◽  
Menière's Disease ◽  
Ménière's Disease

Summating Potential and Water Balance in Meniere's Disease

1986 ◽  
Vol 95 (4) ◽  
pp. 389-395 ◽  
Author(s):  
René Dauman ◽  
Jean-Marie Aran ◽  
Michel Portmann
Keyword(s):  
Action Potential ◽  
Meniere’S Disease ◽  
Menière’S Disease ◽  
Meniere's Disease ◽  
Ménière’S Disease ◽  
Menière's Disease ◽  
Low Frequencies ◽  
Control Subjects ◽  
Summating Potential ◽  
Ménière's Disease

The summating potentials (SP) to free-field 1-, 2-, 4-, and 8-kHz, 90-dB HL tone bursts were recorded by means of transtympanic electrocochleography in 45 patients divided into three groups: those with Meniere's disease, those whose diagnosis was uncertain, and control subjects. The similarities across frequencies between the human SP (promontory) and the experimental SP (DIF component from basal turn) suggest that the SP recorded in electrocochleography originates mostly from the base of the cochlea; negative values were observed at low frequencies (1 to 2 kHz), positive values at high frequencies (8 kHz). Patients with Meniere's disease showed significantly larger SP values than control subjects. The effect of orally administered glycerol on the SP and action potential amplitudes was evaluated by means of automated recordings repeated every 5 minutes. Summating potential values were remarkably constant in the control group. A decrease in SP absolute amplitude was observed in most patients with Meniere's disease and some subjects with uncertain diagnoses, specifically at low frequencies. These changes were frequently associated with action potential amplitude and auditory threshold improvements at low frequencies. It is assumed that the glycerol-induced SP changes at low frequencies are related to modifications in the low frequency mechanical response of the basilar membrane at the basal turn.

Rare cases of Ménière's disease in children

2006 ◽  
Vol 120 (4) ◽  
pp. 343-352 ◽  
Author(s):  
Y H Choung ◽  
K Park ◽  
C H Kim ◽  
H J Kim ◽  
K Kim
Keyword(s):  
Hearing Impairment ◽  
Hearing Threshold ◽  
Meniere’S Disease ◽  
Menière’S Disease ◽  
Meniere's Disease ◽  
Ménière’S Disease ◽  
High Tone ◽  
Menière's Disease ◽  
Number Of Patients ◽  
Ménière's Disease

Classical Ménière's disease is rarely found in children and literature regarding it is scarce. In general, the frequency of Ménière's disease in children is only 0.4–7.0 per cent of that in adults. The progression pattern of Ménière's disease in children is not known well. Here, we report three cases of Ménière's disease in children less than 15 years old, treated over nine years. The three cases comprise 14- and 13-year-old boys and a nine-year-old girl. Two of the three patients initially complained only of recurrent bouts of vertigo, without any tinnitus, ear fullness or hearing impairment. In all three cases, the early pure tone audiograms showed only high tone frequency loss, regardless of subjective hearing loss, and the decrease in the hearing threshold was observed one to eight years after the dizziness attacks began. The hearing threshold was usually decreased to a level of mild or moderate hearing impairment. After diuretic treatment, vertigo was generally well controlled, and some cases showed improvement in hearing. Of the total number of patients with Ménière's disease who visited our department over nine years, 2.6 per cent (3/114) were children, and the overall incidence of Ménière's disease in children with vertigo was 2.0 per cent (3/147). In conclusion, Ménière's disease in children rarely develops and may have characteristics of high tone loss in initial audiograms.

scholarly journals Anatomical variation of inner ear may be a predisposing factor for unilateral Ménière’s disease rather than for ipsilateral delayed endolymphatic hydrops

2022 ◽  
Author(s):  
Ping Lei ◽  
Yangming Leng ◽  
Jing Li ◽  
Renhong Zhou ◽  
Bo Liu
Keyword(s):  
Endolymphatic Hydrops ◽  
Anatomical Variations ◽  
Meniere’S Disease ◽  
Meniere's Disease ◽  
Ménière’S Disease ◽  
Menière's Disease ◽  
Control Subjects ◽  
Delayed Endolymphatic Hydrops ◽  
Ménière's Disease ◽  
And Control

Abstract Objective Radiological anatomical variations, measured by magnetic resonance imaging (MRI), were evaluated in patients with ipsilateral delayed endolymphatic hydrops (DEH) and unilateral Ménière’s disease (MD). The role of anatomical variations in different subtypes of hydropic ear disease was investigated. Methods Twenty-eight patients with ipsilateral DEH, 76 patients with unilateral MD, and 59 control subjects were enrolled. The radiological indices included the distance between the vertical part of the posterior semicircular canal and the posterior fossa (MRI-PP distance) and the visibility of vestibular aqueduct (MRI-VA). These variations among patients with DEH, MD, and control subjects were compared. The correlation between radiological anatomical variations and clinical features or audio-vestibular findings was also examined. Results (1) MRI-PP distance in the affected side of unilateral MD was shorter than that in ipsilateral DEH (Z =  − 2.481, p = 0.013) and control subjects (Z =  − 2.983, p = 0.003), while the difference of MRI-PP distance between the affected side of ipsilateral DEH and control subjects was not statistically significant (Z =  − 0.859, p = 0.391). (2) There was no significant interaural difference of MRI-PP distance in patients with unilateral MD (Z =  − 0.041, p = 0.968) and ipsilateral DEH (t =  − 0.107, p = 0.915) respectively. (3) No significant interaural difference of MRI-VA visibility was observed in patients with unilateral MD (χ2 = 0.742, p = 0.389) and ipsilateral DEH (χ2 = 0.327, p = 0.567) respectively. (4) No correlation was found between these anatomical variables and clinical features or audio-vestibular findings in patients with unilateral MD and ipsilateral DEH respectively (p > 0.05). Conclusions Anatomical variations of inner ear may be a predisposing factor in the pathogenesis of unilateral MD rather than ipsilateral DEH. Key Points • Patients with ipsilateral delayed endolymphatic hydrops showed normal distance between the vertical part of the posterior semicircular canal and the posterior fossa. • Compared to patients with ipsilateral delayed endolymphatic hydrops and control subjects, patients with unilateral Ménière’s disease exhibited shorter distance between the vertical part of the posterior semicircular canal and the posterior fossa. • Anatomical variations of inner ear may be a predisposing factor in the pathogenesis of unilateral Ménière’s disease rather than ipsilateral delayed endolymphatic hydrops.

Effect of Hyperinsulinism on Sensorineural Hearing Impairment in Ménière’s Disease

2014 ◽  
Vol 35 (1) ◽  
pp. 155-161 ◽  
Author(s):  
Joel Lavinsky ◽  
Michelle Lavinsky Wolff ◽  
Andrea Ruschel Trasel ◽  
Marcel Machado Valerio ◽  
Luiz Lavinsky
Keyword(s):  
Hearing Impairment ◽  
Meniere’S Disease ◽  
Sensorineural Hearing ◽  
Menière’S Disease ◽  
Meniere's Disease ◽  
Ménière’S Disease ◽  
Menière's Disease ◽  
Sensorineural Hearing Impairment ◽  
Ménière's Disease
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