Evaluation of the impact of high-tone therapy on cognitive disorders and quality of life in the complex treatment of patients with comorbid pathology

Introduction. Comorbidity is an independent risk factor for mortality and significantly influences the prognosis and quality of life. Purpose: to evaluate the impact of high-tone HiTOP 4 touch therapy on cognitive disorders and quality of life in the complex treatment of patients with comorbid pathology. Methods: complex treatment of 2 groups of patients with inclusion in the basic treatment regimen of high-tone therapy was carried out - a total of 80 patients (men - 34, women - 46) aged 41 to 79 years old, group I - patients with hypertension and chronic cerebral ischemia (CСI) - 38 patients and group II - patients with hypertension, CСI and concomitant diabetes mellitus (DM) type 2 - 42 patients. The average age in group I was 61.5, in group II - 65.5. Group I received lisinopril and amlodipine in one tablet, group II received metformin in addition to the above therapy. Both groups received a course of 10 sessions of high-tone therapy using the device HiTOP 4 touch (Germany) according to the general method: 2 electrodes on the feet, 2 on the forearms and one on the neck-collar area. All the patients were assessed for their cognitive condition, degree of anxiety and depression, and estimated for quality of life before and after a course of high-tone therapy. In order to do this, we used valid assessment tests, such as the Montreal Cognitive Assessment Scale (MoCA), the Hospital Anxiety and Depression Scale (HADS), and the SF-36 Quality of Life Questionnaire. Results: the course of high-tone therapy for patients with hypertension and CCI led to improved quality of life, on all indicators of the SF-36 scale, except for pain intensity, increased cognitive functions by 3.52 points on the MoCA scale, reduced anxiety by 2.06 points and depression by 1.92 points on the HADS scale. The course of high-tone therapy for patients with CCI, hypertension and type 2 DM resulted in a significant improvement of 5 out of 8 quality of life indicators on the SF-36 scale, cognitive functions by 2.27 points on the MoCA scale and reduced anxiety by 4.3 points, and depression by 0.53 points on the HADS scale. Conclusion: the inclusion of high-tone therapy in the complex treatment of patients with comorbid pathology improves cognitive functions, reduces anxiety and depression, improves quality of life. Keywords: comorbid pathology, high-tone therapy, cognitive functions, anxiety, depression, quality of life,

Quadriceps muscle strength recovery with the use of high tone power therapy after anterior cruciate ligament reconstruction: a randomized controlled trial

Background There are no scientific reports clearly describing the effectiveness of the High Tone Power Therapy in patients after ACL reconstruction. This caused that in own research an attempt was made to present the possibilities of using the selected method of electrical stimulation in the treatment of an orthopaedic patient. The aim was to assess the effectiveness of electro stimulation of the quadriceps muscle in patients after ACL reconstruction, with the use of High Tone Power Therapy. Methods In randomized controlled trial took part thirty-five men, aged 21–50, after ACL reconstruction. The tests were carried prior to and 6 months following the ACL reconstruction. After the surgery, the patients were randomly divided into experimental group (17 patients) with the High Tone Power Therapy in rehabilitation and control group (18 patients) without the High Tone Power Therapy. Patients were subjected to 6-month rehabilitation. Research tools included the measurement of muscle strength torque, ROM, knee and thigh circumference measurements, the Lysholm and the VAS scale. Results After applying HiToP, the analysis showed a statistically significant improvement of muscle torque (p = 0.041, Es = 3.71), knee circumference (p = 0.039, Es = 1.65), thigh circumference (p = 0.049, Es = 1.26), knee extension (p < 0.001, Es = 2.20) in Experimental group compared to the control group. Only the results of the VAS scale did not differ statistically significantly both within a given group and between groups. Conclusions The results confirm the hypothesis that the use of HiToP in patients after ACLr have a beneficial effect on muscle strength, reduction of joint effusion, muscle mass gain and joint function. The assumption that HiToP significantly reduces pain levels is not supported - the results in both groups are statistically insignificant. Trial registration The research project was retrospectively registered in the Australian New Zealand Clinical Trials Registry (ANZCTR). Date of first registration 11.10.2016. Registration number: ACTRN12616001416482.

A Case Report of COL4A5 Gene Mutation Alport Syndrome in 2 Native African Children

Alport syndrome is a heterogeneous genetic disease involving the basement membrane of the glomeruli, inner ear, retina, and lens capsule. It typically manifests as progressive glomerulopathy that frequently results in end-stage renal disease, high-tone sensorineural deafness, and ocular abnormalities of anterior lenticonus and yellow and white dots and flecks on the macular of the retina. In this report, we describe the cases of 2 siblings: 15- and 13-year-old boys of pure African descent with the <i>COL4A5</i> gene mutation. Both children had the classical features of Alport syndrome haematuria, proteinuria, progressive sensorineural high-tone hearing loss, and ocular abnormalities. Their renal abnormalities initially regressed on therapy with angiotensin-converting enzyme inhibitors but reoccurred, depicting the need for early diagnosis as the early institution of this therapy before significant glomerulopathy is advocated.

Is discourse made up of sentences? Focusing on dependent grafted speech in modern standard Japanese

The idea that discourse is made up of sentences has been widespread among linguists. Does this traditional discourse perspective (“sententialism”) apply to casual language in daily communication? This paper examines the validity of sententialism by focusing on a type of speech called “dependent grafted speech” in Japanese conversation. Close examinations of various words, phrases, and sentences reveal that dependent grafted speech is different from sentences on two points: (i) Generally, the lexical accent of the copula at the beginning of dependent grafted speech is a high tone; and (ii) the interaction particle at the end of dependent grafted speech is not uttered with a falling intonation unless it is proceeded by a very abrupt rising intonation (“leaping” intonation). These findings cast doubt on the status of dependent grafted speech as a sentence. Moreover, they demonstrate a new conception of discourse as a mixture of diverse constituents, including sentences, dependent grafted speech, and other utterance types.

Tone, stress, quantity, and quality: prosodic patterns and tonal wug-tests in Žiri Slovenian

The prosodic systems of the world’s languages vary widely in their complexity. In this paper, we report on a prosodic pattern in Žiri Slovenian, which displays an intricate set of interactions between tone, stress, quantity, and vowel quality. Some of the prosodic patterns are well motivated (e.g. the preference of High tone syllables to be stressed) while others lack phonetic or phonological motivation (e.g. the preference of long vowels to fall on the second syllable of a trochaic foot). Žiri also displays a rare case of interaction of prosody with vowel quality. To confirm productivity of the observed patterns, we conducted a wug experiment that tested the dependence of stress on vowel quality, word length, and tone. All in all, this paper brings forth new instances of phonetically unmotivated phonological processes at the suprasegmental level, which appear less discussed than at the segmental level. We also discuss methodological issues arising from artificial experiments on tonal processes.

Negation in Languages: A Urhobo Perspective

This paper examines negation and types of tense negation in Urhobo. It also identifies negation marker(s) and the manner in which these negation marker(s) are used in sentences. Transformational generative grammar theory of analysis was used in the work. The aim of this study is to determine the syntactic characteristics of negation in Urhobo. The study shows that negative construction in the Urhobo language involves the doubling of the last vowel of the last word in sentences; or what may be called the lengthening of the last vowel of the lexical item in the sentence. Also, the low-high tone can do the same function as the lexical or grammatical tone. It was observed that negation is a natural phenomenon that cuts across Urhobo, and that the orthographic representation of the low tone, which is the copying of the final vowel, is written contiguously while other negative markers are written separately. It was also observed that Urhobo operates suffixation. Finally, the study work reveals ejo, je, odie and and oyen as negative markers in Urhobo.

A Constraint-based Analysis of Obligatory Contour Principle in Anaang Morphological Constructions

The obligatory contour principle forbids identical consecutive features in the underlying representation. This work undertakes a description of the Anaang tonal structure, the tonal behaviour of compounds and reduplicates in the language, bearing in mind their sensitivity to the OCP and the environments that trigger the adherence. An adapted Ibadan wordlist of 400 Basic Items (Trial) English version was used via interview for data collection from six men and six women within Abak Local Government Area in Akwa Ibom State. The data were analysed using optimality theoretical framework. The analysis shows that Anaang compounds as well as reduplicates exhibit cases of tonal modifications in line with OCP. For compounds, the tone of the second noun changes depending on the tonal sequence. In the HH noun base, the second-high tone of the second noun changes to a low tone, in the LH noun base, the tone of the second noun is raised to a down-stepped high tone, the LL noun base sees the tone of the second noun being raised to a high tone. For reduplication, the tone of the L verb base changes when the redup lication is partial. When the reduplication is complete, the high tone of the second noun is down-stepped.

The intonation of yes–no questions in Luganda

The intonation of yes–no questions in Luganda (Bantu, Uganda) has only been sketched in passing. Hyman states that Luganda yes–no questions are marked by a ‘super-high tone’ immediately following the last lexical high tone in the sentence, but there is little agreement in the literature about the intonation of yes–no questions if there is no lexical high tone in the sentence. To clarify the differences between statements and yes–no questions in Luganda, an acoustic production study was conducted. Nineteen speakers read aloud sentences differing in the location of the last lexical high tone relative to the end of the sentence. Each sentence was produced as a statement and as a question. Analysis of f0 measurements supported Hyman’s description of sentences with a lexical high tone, since the questions had an f0 peak that was higher and later than in the corresponding statements. For sentences without a lexical high tone, yes–no questions were found to begin with an interval in which f0 is higher than in corresponding statements, and end with a final f0 value lower than in statements. It is proposed that the yes–no question marker is a phrase accent (H–). Like the high phrase accent posited by Pierrehumbert for English, this intonational tone is associated after the last tone in the phrase, but in Luganda that last tone is lexical, rather than being an intonational focus marker as in English. This H– accent is subject to upstep in the position after a high tone.