scholarly journals Vitreous and Optic Nerve Infiltration of an Adrenal B Lymphoma

2021 ◽  
pp. 915-920
Author(s):  
Lucía Galletero Pandelo ◽  
Cristina Rodríguez Vidal ◽  
Joseba Artaraz ◽  
Nerea Martínez-Alday ◽  
Alex Fonollosa
Keyword(s):  
Optic Nerve ◽  
Optic Disc ◽  
Brain Magnetic Resonance Imaging ◽  
B Cell Lymphoma ◽  
Extensive Study ◽  
Optic Disc Edema ◽  
B Lymphoma ◽  
Disc Edema ◽  
Ocular Movements ◽  
Large B Cell Lymphoma

<b><i>Aim:</i></b> This study aimed to report a case of vitreous and optic nerve infiltration of a primary adrenal B lymphoma. <b><i>Case Report:</i></b> An 81-year-old patient consulted for decrease in vision in the left eye and pain with ocular movements during the last week. The patient was being treated with chemotherapy for an adrenal gland diffuse large B-cell lymphoma. On examination, vitritis was seen in both eyes and optic disc edema in his left eye. After an extensive study based on orbital and brain magnetic resonance imaging and vitreous cytology, an ocular infiltration by systemic B lymphoma was confirmed. A treatment based on intravitreal methotrexate was carried out, achieving the regression of the vitreous infiltration and resolution of the optic disc edema. Systemic B lymphoma metastasizing ocular structures is extremely infrequent. The manifestations may mimic an inflammatory disease. Ophthalmologists should be aware of these manifestations and consider among the masquerade syndromes.

Morphology of Retinal Vessels in Patients With Optic Nerve Head Drusen and Optic Disc Edema

2014 ◽  
Vol 55 (6) ◽  
pp. 3484 ◽  
Author(s):  
Anastasia V. Pilat ◽  
Frank A. Proudlock ◽  
Rebecca J. McLean ◽  
Mark C. Lawden ◽  
Irene Gottlob
Keyword(s):  
Optic Nerve ◽  
Optic Disc ◽  
Optic Nerve Head ◽  
Retinal Vessels ◽  
Optic Disc Edema ◽  
Disc Edema ◽  
Optic Nerve Head Drusen

Macular Morphology in Patients with Optic Nerve Head Drusen and Optic Disc Edema

Ophthalmology ◽  
2014 ◽  
Vol 121 (2) ◽  
pp. 552-557 ◽  
Author(s):  
Anastasia V. Pilat ◽  
Frank A. Proudlock ◽  
Periyasamy Kumar ◽  
Helena Lee ◽  
Eleni Papageorgiou ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Disc ◽  
Optic Nerve Head ◽  
Optic Disc Edema ◽  
Disc Edema ◽  
Optic Nerve Head Drusen

Pseudopapilledema

2019 ◽  
pp. 55-60
Author(s):  
Matthew J. Thurtell ◽  
Robert L. Tomsak
Keyword(s):  
Optic Nerve ◽  
Optic Disc ◽  
Optic Nerve Head ◽  
Imaging Techniques ◽  
Optic Disc Edema ◽  
Diagnostic Dilemma ◽  
Disc Edema ◽  
Head Elevation ◽  
Ophthalmic Imaging ◽  
Optic Nerve Head Drusen

A diagnostic dilemma often arises when a patient with headaches is found to have optic nerve head elevation. In this chapter, we begin by reviewing the potential causes of optic nerve head elevation, which include papilledema, optic disc edema from another cause, optic nerve head infiltration, and anomalous optic nerve head elevation that mimics optic disc edema (pseudopapilledema). We next list the common causes of pseudopapilledema and discuss strategies that help to distinguish pseudopapilledema from papilledema. We then review the clinical features and diagnostic evaluation of optic nerve head drusen, a common cause of pseudopapilledema, and describe ophthalmic imaging techniques that can help to distinguish optic nerve head drusen from papilledema.

scholarly journals Incipient Non-Arteritic Anterior Ischemic Optic Neuropathy in a Patient with Metastatic Small-Cell Lung Cancer

2021 ◽  
pp. 513-518
Author(s):  
Arshia Eshtiaghi ◽  
Jonathan A. Micieli
Keyword(s):  
Lung Cancer ◽  
Optic Nerve ◽  
Magnetic Resonance ◽  
Optic Disc ◽  
Visual Function ◽  
Small Cell ◽  
Ischemic Optic Neuropathy ◽  
Small Cell Lung ◽  
Optic Disc Edema ◽  
Disc Edema

A 70-year-old woman with metastatic small-cell lung cancer was referred for isolated left optic disc edema that was incidentally discovered. She had normal visual function, and dilated fundus examination revealed a small, cupless optic nerve in the right eye and moderate optic disc edema in the left eye. Magnetic resonance imaging (MRI) of the orbits with contrast was normal, and MRI brain and magnetic resonance venography were normal without signs of raised intracranial pressure. Lumbar puncture showed a normal opening pressure and normal cerebrospinal fluid contents. A diagnosis of incipient non-arteritic anterior ischemic optic neuropathy (NAION) was made, and the optic disc edema resolved after 4 months. Incipient NAION is an uncommon cause of unilateral optic disc edema with preserved visual function and is a diagnosis of exclusion. In diagnosing incipient NAION, other causes of optic disc edema must first be ruled out. These alternative causes include papilledema, optic nerve sheath meningioma or other orbital masses, and vitreopapillary traction. Incipient NAION is thought to be caused by subclinical ischemia. This case indicates that incipient NAION may also occur in patients with metastatic cancer and is possibly related to their hypercoagulable state. Although there is no treatment once vision loss develops, the optimization of risk factors may prevent the progression of incipient NAION to classic NAION.

scholarly journals Optic Nerve Head Elasticity and Corneal Biomechanics in Patients with Optical Disc Drusen and Optic Disc Edema

2021 ◽  
Author(s):  
Ozge SARAC ◽  
Yelda Y TASCI ◽  
Nilufer YESILIRMAK ◽  
Ozlem UNAL ◽  
Semih ONER ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Disc ◽  
Optic Nerve Head ◽  
Corneal Biomechanics ◽  
Optic Disc Edema ◽  
Disc Edema ◽  
Significant Difference ◽  
The Mean ◽  
Group 2 ◽  
Group 1

Abstract Purpose: The purpose of the study is to evaluate the efficacy of ultrasound elastography (USE) in differentiating optic disc drusen (ODD) from optic disc edema (ODE) and to investigate the relationship between corneal biomechanics and optic nerve elasticity. Methods: This prospective, clinical study included 28 eyes of 16 ODD patients (Group 1), 23 eyes of 18 ODE patients (Group 2) and 30 eyes of 15 healthy controls (Group 3). Best corrected distance visual acuity (BDVA), corneal hysteresis (CH), corneal resistance factor (CRF), corneal-compensated intraocular pressure (IOPcc), Goldmann-correlated IOP (IOPg) and optic nerve head (ONH)-elasticity were measured. Results: The mean BDVA value was significantly lower in Group 2 compared to Groups 1 and 3 (p<0.001), there was no significant difference between Groups 1 and 3 (p=0.089). The mean intraconal fat to ONH ratio was significantly higher in Group 1 compared to Group 2 (p=0.008) and 3 (p=0.002), there was no significant difference between Group 2 and 3 (p=0.182). The receiver operating characteristic curve areas for ONH-elasticity in differentiating group 1 and group 2 was 0.728 (p=0.008) with 80% sensitivity and 60% specificity when the cut-off point was set at 2.29. Corneal biomechanics (CH, CRF, IOPcc, IOPg) were not different between the three groups (p>0.05), however there was a significant correlation between corneal and ONH biomechanics in drusen group (p<0.05). Conclusion: The evaluation of the ONH with USE seems to provide useful data in differentiating ODD from ODE. Significant correlation was revealed between corneal and ONH biomechanics in drusen group.

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