Pearls & Oy-sters: Delayed Diagnosis of Acute Motor Axonal Neuropathy With Cardiac Arrest

We present the case of a 53-year-old female who presented with right lower extremity weakness with preceding systemic symptoms including fever and chest pain. She developed rapid quadriparesis over 24 hours and had ventricular fibrillation with cardiac arrest. Examination demonstrated tetraplegia, facial diplegia with spared extra-ocular movements and areflexia. Electrodiagnostic studies including nerve conduction studies and electromyography were consistent with Acute Motor Axonal Neuropathy (AMAN). This case highlights an atypical asymmetric presentation with initially preserved reflexes, rapid progression and cardiac dysfunction that can occur independent of dysautonomia. Treatment options include intravenous immunoglobulin (IVIg) or plasmapheresis as well as supportive care and long term multidisciplinary rehabilitation and communication strategies.

Vitreous and Optic Nerve Infiltration of an Adrenal B Lymphoma

<b><i>Aim:</i></b> This study aimed to report a case of vitreous and optic nerve infiltration of a primary adrenal B lymphoma. <b><i>Case Report:</i></b> An 81-year-old patient consulted for decrease in vision in the left eye and pain with ocular movements during the last week. The patient was being treated with chemotherapy for an adrenal gland diffuse large B-cell lymphoma. On examination, vitritis was seen in both eyes and optic disc edema in his left eye. After an extensive study based on orbital and brain magnetic resonance imaging and vitreous cytology, an ocular infiltration by systemic B lymphoma was confirmed. A treatment based on intravitreal methotrexate was carried out, achieving the regression of the vitreous infiltration and resolution of the optic disc edema. Systemic B lymphoma metastasizing ocular structures is extremely infrequent. The manifestations may mimic an inflammatory disease. Ophthalmologists should be aware of these manifestations and consider among the masquerade syndromes.

Surgical management of Helveston syndrome (Triad exotropia)

Purpose To evaluate and compare different surgical approaches for the treatment of Helveston syndrome and provide further information for preoperative planning. Methods From February 2008 to December 2018, data of 52 patients with Helveston syndrome were retrospectively reviewed. Different surgical approaches were selected based on the extent of A-pattern exotropia, dissociated vertical deviation (DVD), and both superior oblique muscle overaction (SOOA) with fundus photograph intorsion. Eye position, A-pattern, DVD, superior oblique muscle function, and binocular vision function were evaluated pre- and postoperatively. The average follow-up duration was 20.5 months. Results Nine cases underwent simultaneous horizontal deviation correction with bilateral superior rectus recession, 24 underwent simultaneous horizontal deviation correction with bilateral superior oblique muscle lengthening, and 19 underwent two stages of horizontal deviation correction with superior oblique muscle lengthening, and later bilateral superior rectus recession. A-pattern, DVD, SOOA, and fundus intorsion were all collapsed in all patients postoperatively. Forty-five patients had an orthophoric eye position with considerably aligned ocular movements postoperatively. The total success rate was 86.5%. Postoperatively, eight of the 10 patients with diplopia experienced a recovery of binocular single vision and three had a recovery of rudimentary stereopsis (Titmus 3000–400 s of arc). The compensatory head posture of patients improved significantly postoperatively. Conclusions The surgical planning of Helveston syndrome should be designed based on the degree of the A-pattern, SOOA, DVD, and the intorsion in fundus photographs, and the appropriate approach should be selected to improve patient satisfaction.

Validation of a modified version of the adult developmental eye movement test

This study evaluates in terms of reliability, internal consistency, and validity a modification of the Adult Developmental Eye Movement (ADEM) test, ADEM with distractors (ADEMd), designed to analyse oculomotor system, visual processing and visual attentional behaviour. 302 healthy subjects participated in the study (20–86 years old). Intrasession repeatability was evaluated by analysing the correlation between the time needed to read different parts of the test. Inter-session analyses were carried in 40 subjects by calculating intraclass correlation coefficients and using the Bland–Altman method. Validity was assessed in the outcomes obtained according to age as well as investigating the correlation between ADEMd and attentional useful field of vision (UFOV) test. Correlation coefficients between times need to read each sheet were ≥ 0.95 (p < 0.001). The inter-session intraclass correlation coefficient ranged from 0.81 in the horizontal distractor sheet to 0.97 in the vertical sheet. Bland–Altman analysis showed clinically acceptable limits of agreement. Statistically significant correlations were found between age and ADEMd outcomes (r ≥ 0.55, p < 0.001). Processing velocity, divided attention and selective attention measured with the UFOV were correlated with the horizontal distractor times (r ≥ 0.32, p < 0.001). ADEMd test may be a useful clinical tool to evaluate the combined interaction of ocular movements and visual attentional behaviour.

Study of Clinical Findings and Treatment Outcomes of Rhino-OrbitalCerebral Mucormycosis at a Tertiary Care Center in Central India

BACKGROUND Mucormycosis is a potentially lethal angioinvasive fungal infection. Increasing incidence of rhino-orbital-cerebral mucormycosis in setting of corona virus disease-19 (COVID-19) during second wave in India and elsewhere has become a matter of immediate concern. This study was done to assess the clinical findings and treatment outcomes of rhino-orbital-cerebral-mucormycosis presenting to a tertiary care center in central India. METHODS This is a longitudinal study. We observed 38 COVID-19 associated mucormycosis cases. Their demographic data, clinical manifestations, underlying systemic conditions, microbiological and radiological reports, medical treatments and surgical interventions were recorded and analysed. RESULTS Common ocular presenting features were ophthalmoplegia (68 %), proptosis (44 %), periorbital swelling (13 %), diminution of vision (37 %), central retinal arterial occlusion (2.5 %), optic atrophy (2.5 %). Visual acuity at 1 month after surgery was compared with that at presentation and was found unchanged in 27 patients, improved in 3 patients and deteriorated in 6 patients. Functional outcome was evaluated in terms of ocular movements, and it was found that ocular movements were same as presentation in 30 patients, improved in 3 patients and deteriorated in 3 patients at follow up one month after surgery. Radiological outcome was evaluated, and it was found that residual disease was present in 4 patients and absent in 32 patients. Mortality was found in 2 patients at 1 month follow-up period. CONCLUSIONS Early diagnosis, blood sugar levels control, urgent systemic antifungal therapy and sinus debridement surgery are lifesaving in cases of COVID-19 associated mucormycosis. KEYWORDS Mucormycosis, COVID-19, Diabetes Mellitus, Ophthalmoplegia, Orbital Apex Syndrome, Orbital Cellulitis, Proptosis

Vogt-Koyanagi-Harada Disease Following COVID-19 Infection

A 29-year-old female presented to the emergency clinic with gradual visual disturbance in both eyes for 15 days duration, accompanied by bilateral tinnitus, and ocular pain that increased with ocular movements. One month prior to presentation, the patient had tested positive for severe acute respiratory syndrome coronavirus-2 but without complications. Visual acuity was 20/100 in the right eye and 20/300 in the left eye. Funduscopy demonstrated optic nerve swelling, radial nerve fiber striation disruption, and bilateral retinal folds. Optical coherence tomography showed serous (bacillary) retinal detachment and multifocal areas of hyper-reflective changes in the inner and outer plexiform layer with inner nuclear layer thickening and disruption of the interdigitation zone bilaterally. We present a case of incomplete Vogt-Koyanagi-Harada disease following COVID-19 infection.

Visual disturbances in patients with pituitary tumors and early improvement of visual acuity and visual field defects after resection of pituitary tumors.

Objective: The aim behind this study was to determine the frequency of visual field and visual acuity disturbances before resection and improvement after resection of pituitary tumors in patients. Study Design: Observational study. Setting: Neurosurgery Department of Jinnah Post Graduate Medical Center, Karachi. Period: August 2015 to August 2016. Material & Methods: A total of 30 patients presented with headache and visual deterioration and diagnosed as pituitary adenoma at neurosurgery OPD, ward and ER were included through a consecutive purposive sampling technique. The detailed visual and ocular analysis (visual acuity, visual field, and extra ocular movements) carried out at time of admission and postoperatively. Tumor was removed by consultant neurosurgeon through trans-sphenoidal approach. SPSS version 17.0 was used to analyze the collected data. Results: A total of 30 cases of pituitary adenoma were included. The average age of the patients was 34.5 ± 10.8 years and among them 17 (56.7%) were males and 13 (43.3%) were females. Pre-operative assessment of the mean deviation of visual function was -8.21 ± 6.10 dB which is significantly improved to -4.6 ± 3.9 dB post-operatively (P < 0.0001). While pre-operative Visual Acuity (logMAR) was 0.3 ± 0.26 and post-operative 0.21 ± 0.2 (P <0.0001). Conclusion: Scientific observation from our study has shown that more than 90% of the patients suffering from pituitary adenomas experience visual impairment which can be improved to significant extent if treated with trans-sphenoidal surgical resection of the tumor.

Clinical Profile and Visual Outcome of Optic Neuritis Patients in Mysore Medical College and Research Institute, India

BACKGROUND Blindness is a major health problem worldwide and India has been an epicenter in the number of blindness cases. The causes of blindness, natural history differs between western countries and India. When it comes to optic neuritis the pattern in developing countries is different than developed countries. Multiple sclerosis is one of the major causes of disability disease in US and one of the most common early manifestations is optic neuritis. Early identification and early management have shown promises in reducing ocular morbidity as well as neurological morbidity and recurrences. But the trend of optic neuritis in India is very different and not many studies have been conducted to know about this disease and its causes in this geographical region. We wanted to evaluate the clinical profile and visual outcome of optic neuritis in India. METHODS It was a prospective study done for a duration of 10.8 +/- 8.4 months in which all patients clinically diagnosed with optic neuritis were studied. Thirty patients were included in the study. They were followed up and visual parameters were assessed and thus clinical profiling and visual outcomes were done. RESULTS Mean age was 39.3667 ± 14.03563 years. Female preponderance was seen (63.33 % of cases). Retrobulbar neuritis (56.7 % of eyes) was more common than papillitis (43.33 % of eyes) but papillitis was a more common presentation in males (73.7 %). Bilateral presentation was seen in 23.33 % cases. All patients complained of DOV but pain on ocular movements were complained by 36.66 % patients. Baseline median logMAR visual acuity (VA) was 1.17 ± 0.8, which improved to 1.6 ± 0.6, within one week and 0.79 +/- 0.6 within one month improving to 0.55 +/- 0.6 in three months. Approximately 64.68 % of eyes retained VA of or 6/18 or more. Colour vision recovery was noted in 39.86 %. Demyelinating lesions in the brain were present in 2 patients, one of which was already diagnosed as MS. One case on follow up was eventually diagnosed as multiple sclerosis. CONCLUSIONS In Indian scenario the profile of optic neuritis is different. Here incidence of papillitis is more or equal to that of retrobulbar optic neuritis, visual recovery is poor, causes being more of infectious or idiopathic and less recurrence rate. KEY WORDS Optic Neuritis, Clinical Profile, Visual Outcome, Developing Countries Ontt

Orbital pseudotumor masquerading orbital cellulitis

Here with presenting a case of pseudotumor orbit initially diagnosed as orbital cellulitis which responded to steroids. A 44 year old male presented with complaints of swelling, redness, watering and inability to open the right eye for 1 day. He had no h/o trauma or insect bite. On examination, visual acuity in both eyes was 6/6. The right eye was proptosed with gross restriction of the extra ocular movements, conjunctival congestion and chemosis. The intra ocular pressure was 52 mm Hg. The left eye was normal. CT orbit showed enlargement of right lateral rectus muscle and lacrimal gland, with fat stranding and soft tissue thickening of periorbital, pre septal and perinasal regions diagnostic of pseudotumor tumour. He was started on high dose oral steroids with which he improved dramatically.

The loss of an eye due to occupational injury: Two case studies of ocular prosthetic rehabilitation

BACKGROUND: Two patients received ocular injuries from rusted metallic projectiles at their industrial workplaces. Said injuries resulted in the loss of their eyes by evisceration surgeries to prevent fatal infections. CASE DESCRIPTION: The first case, a man in his twenties, received a stock conformer immediately after surgery and started prosthetic therapy within 2 months. The second case, a man in his forties, started prosthetic therapy after 10 years. Definitive custom ocular prostheses were fabricated and relined according to conventional protocol. RESULTS: On issue of the prosthesis, there was adequate retention, aesthetics and stability to extra-ocular movements and treatment was considered successful for both cases. However, follow-ups showed noticeable prosthetic eye movements for case 1 which, to some extent mimicked the physiologic movement of its fellow natural eye. Case 1 adjusted to his prosthesis better while case 2 was still adjusting with little to no physiologic movement. CONCLUSION: Prosthetic rehabilitation should be started as early as possible to obtain optimum rehabilitative results.