scholarly journals PLEURAL ENDOMETRIOSIS: BLOODY PLEURAL EFFUSION IN A 28-YEAR-OLD FEMALE WITH PRIMARY INFERTILITY (CASE REPORT)

2021 ◽  
Vol 6 (2) ◽  
pp. 11-15
Author(s):  
S. Saheer ◽  
A. Paul ◽  
P. James ◽  
R. Palak
Keyword(s):  
Case Report ◽  
Pleural Effusion ◽  
Uterine Cavity ◽  
Pulmonary Nodules ◽  
Pelvic Cavity ◽  
Primary Infertility ◽  
Medical Thoracoscopy ◽  
Hemorrhagic Pleural Effusion ◽  
Thoracic Endometriosis

Background. Endometriosis is defined as presence of endometrial glands outside the uterine cavity and it most commonly involves the structures within the pelvic cavity. Thoracic endometriosis syndrome usually presents as pneumothorax, hemoptysis, hemothorax or pulmonary nodules. Endometriosis presenting as hemorrhagic pleural effusion is rarely reported. Objectives. The aim of the study was to describe pleural endometriosis presenting as hemorrhagic pleural effusion and to insist on the role of medical thoracoscopy in making the diagnosis with the help of a case report. Methods. A case report of pleural endometriosis as a non-resolving hemorrhagic pleural effusion is presented. Results. A 28-years old female on treatment for her primary infertility presented with non-resolving bloody pleural effusion and she was on empirical anti-tubercular drugs for the last four months. Medical thoracoscopy revealed flat brownish grey plaques over the diaphragmatic pleura and the histology of pleural tissue revealed pleural endometriosis. She was initiated on gonadotropin releasing hormone-leuprolide and there was some clinico-radiological improvement. Conclusions. Thoracic endometriosis should be considered as one of the differentials for pleural effusion in female patient especially on treatment for infertility. Medical thoracoscopy should be the investigation of choice for evaluating pleural effusions before initiating empirical treatments.

scholarly journals Estrogen- and Progesterone (P4)-Mediated Epigenetic Modifications of Endometrial Stromal Cells (EnSCs) and/or Mesenchymal Stem/Stromal Cells (MSCs) in the Etiopathogenesis of Endometriosis

2021 ◽  
Author(s):  
Dariusz Szukiewicz ◽  
Aleksandra Stangret ◽  
Carmen Ruiz-Ruiz ◽  
Enrique G. Olivares ◽  
Olga Soriţău ◽  
...  
Keyword(s):  
Stromal Cells ◽  
Uterine Cavity ◽  
Retrograde Transport ◽  
Surrounding Tissue ◽  
Pelvic Cavity ◽  
Endometrial Stromal Cells ◽  
Endometrial Cells ◽  
Estrogen Exposure ◽  
Chronic Inflammatory Condition

AbstractEndometriosis is a common chronic inflammatory condition in which endometrial tissue appears outside the uterine cavity. Because ectopic endometriosis cells express both estrogen and progesterone (P4) receptors, they grow and undergo cyclic proliferation and breakdown similar to the endometrium. This debilitating gynecological disease affects up to 15% of reproductive aged women. Despite many years of research, the etiopathogenesis of endometrial lesions remains unclear. Retrograde transport of the viable menstrual endometrial cells with retained ability for attachment within the pelvic cavity, proliferation, differentiation and subsequent invasion into the surrounding tissue constitutes the rationale for widely accepted implantation theory. Accordingly, the most abundant cells in the endometrium are endometrial stromal cells (EnSCs). These cells constitute a particular population with clonogenic activity that resembles properties of mesenchymal stem/stromal cells (MSCs). Thus, a significant role of stem cell-based dysfunction in formation of the initial endometrial lesions is suspected. There is increasing evidence that the role of epigenetic mechanisms and processes in endometriosis have been underestimated. The importance of excess estrogen exposure and P4 resistance in epigenetic homeostasis failure in the endometrial/endometriotic tissue are crucial. Epigenetic alterations regarding transcription factors of estrogen and P4 signaling pathways in MSCs are robust in endometriotic tissue. Thus, perspectives for the future may include MSCs and EnSCs as the targets of epigenetic therapies in the prevention and treatment of endometriosis. Here, we reviewed the current known changes in the epigenetic background of EnSCs and MSCs due to estrogen/P4 imbalances in the context of etiopathogenesis of endometriosis.

scholarly journals Pleural effusion as first extra-medullary clinical presentation of an occult multiple myeloma: The role of medical thoracoscopy

2020 ◽  
Vol 29 ◽  
pp. 101013
Author(s):  
Antonietta Coppola ◽  
Giacomo Ghinassi ◽  
Giuseppina Ciarleglio ◽  
Uberto Maccari ◽  
Laura Salerno ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Pleural Effusion ◽  
Clinical Presentation ◽  
Medical Thoracoscopy

scholarly journals Thoracic Endometriosis

2018 ◽  
Author(s):  
Mohey M. Saleh, M.D ◽  
Noor Sameh Darwich ◽  
Ejaz Ahmad , M.D.
Keyword(s):  
Pleural Effusion ◽  
Young Female ◽  
Pelvic Endometriosis ◽  
Childbearing Age ◽  
Pleural Biopsy ◽  
Talc Pleurodesis ◽  
Hemorrhagic Pleural Effusion ◽  
History Of ◽  
Thoracic Endometriosis ◽  
Pleural Involvement

Abstract: A recurrent hemorrhagic pleural effusion in a woman during her reproductive years may be the clinical presentation of thoracic endometriosis syndrome (TES) . We report here a case of a recurrent bloody right pleural effusion in a young female who had a history of pelvic endometriosis. Thoracic endometriosis with pleural involvement was confirmed by pleural biopsy which showed focal involvement of functional endometrial tissue within the pleura. The patient underwent pleurectomy and talc pleurodesis without recurrence of the pleural fluid. A hemorrhagic pleural effusion due to thoracic endometriosis may mimic other conditions including pulmonary thromboembolism, trauma, malignancy, tuberculosis, and others. Thoracic endometriosis should be in the differential diagnosis of a bloody pleural effusion in women of childbearing age, particularly in a patient with an established diagnosis of pelvic endometriosis.

scholarly journals Role of Mesothelin Measurement in Patients With Cytology-Negative Pleural Effusion Undergoing Medical Thoracoscopy

PLEURA ◽  
2015 ◽  
Vol 2 ◽  
pp. 237399751557963
Author(s):  
Su Lyn Leong ◽  
Y. C. Gary Lee ◽  
Bruce W. Robinson ◽  
Jenette Creaney
Keyword(s):  
Pleural Effusion ◽  
Medical Thoracoscopy

Recurrent pleural effusion and pain in the shoulder in women of reproductive age could have a gynecological cause: case series

2019 ◽  
Vol 8 (2) ◽  
Author(s):  
Luka Matak ◽  
Ivan Bačić ◽  
Jakov Mihanović ◽  
Nataša Lisica-Šikić ◽  
Branko Dukić ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Case Series ◽  
Uterine Cavity ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Gynecological Disease ◽  
The Right ◽  
Thoracic Endometriosis ◽  
Recurrent Pleural Effusion ◽  
Treatment And Diagnosis

Abstract Background Endometriosis is a benign disorder defined as the presence of endometrial glands and stroma outside of the uterine cavity. It has been estimated that approximately 10% of the women of reproductive age and 30–50% of the women with infertility are affected. Case presentation We report two nulliparous patients with recurrent pleural effusion and pain in the right shoulder highly suspicious for thoracic endometriosis syndrome (TES). Conclusion The objective of this study was to present patients with unusual symptoms related to gynecological disease. The second aim was to show our single institution experience as a second level hospital in terms of treatment and diagnosis of TES and diaphragmatic endometriosis.

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