scholarly journals 31P magnetic resonance spectroscopy in dilated cardiomyopathy and coronary artery disease. Altered cardiac high-energy phosphate metabolism in heart failure.

Circulation ◽  
1992 ◽  
Vol 86 (6) ◽  
pp. 1810-1818 ◽  
Author(s):  
S Neubauer ◽  
T Krahe ◽  
R Schindler ◽  
M Horn ◽  
H Hillenbrand ◽  
...  
Keyword(s):  
Heart Failure ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Magnetic Resonance ◽  
High Energy ◽  
Resonance Spectroscopy ◽  
Phosphate Metabolism ◽  
High Energy Phosphate ◽  
Artery Disease ◽  
High Energy Phosphate Metabolism

High-energy phosphate metabolism in a neonatal model of hydrocephalus before and after shunting

1994 ◽  
Vol 81 (4) ◽  
pp. 544-553 ◽  
Author(s):  
Marcia C. da Silva ◽  
James M. Drake ◽  
Claude Lemaire ◽  
Albert Cross ◽  
Ursula I. Tuor
Keyword(s):  
Magnetic Resonance ◽  
Mr Imaging ◽  
Mr Spectroscopy ◽  
High Energy ◽  
Resonance Spectroscopy ◽  
Phosphate Metabolism ◽  
Energy Index ◽  
High Energy Phosphate ◽  
High Energy Phosphate Metabolism ◽  
The Impact

✓ The authors studied the effects of hydrocephalus on the high-energy phosphate metabolism of the brain and the impact of ventriculoperitoneal (VP) shunting on these changes in an experimental model of hydrocephalus. High-energy phosphate metabolism was analyzed using in vivo magnetic resonance (MR) imaging and 31P MR spectroscopy. Hydrocephalus was produced in 34 1-week-old kittens by cisternal injection of 0.05 ml of a 25% kaolin solution. Sixteen litter mates were used as controls. A VP shunt with a distal slit valve was implanted in 17 of the 34 hydrocephalic animals 10 days after induction of hydrocephalus. Both MR imaging and 31P MR spectroscopy were obtained 1 and 3 weeks after either kaolin or distilled water injection. Untreated hydrocephalic animals had marked dilatation of the lateral ventricles and periventricular edema. Magnetic resonance spectroscopy showed a significant decrease in the energy index ratio of phosphocreatine (PCR): inorganic phosphate (PI) and an increase in the PI:adenosine triphosphate (ATP) ratio. There was a direct correlation between the decrease in the energy index and ventricular size. Compared with preoperative scans, shunted animals showed no periventricular edema, and the ventricles decreased in size. Also, PCR:PI and PI:ATP ratios were within the levels of controls. This study suggests that neonatal hydrocephalus results in a mild hypoxic/ischemic insult that is treatable by VP shunting.

Sign in / Sign up

Export Citation Format

Share Document