Transition from compensated hypertrophy to intrinsic myocardial dysfunction during development of left ventricular pressure-overload hypertrophy in conscious sheep. Systolic dysfunction precedes diastolic dysfunction.

Circulation ◽  
1993 ◽  
Vol 88 (5) ◽  
pp. 2415-2425 ◽  
Author(s):  
T Aoyagi ◽  
A M Fujii ◽  
M F Flanagan ◽  
L W Arnold ◽  
K W Brathwaite ◽  
...  
Keyword(s):  
Diastolic Dysfunction ◽  
Myocardial Dysfunction ◽  
Systolic Dysfunction ◽  
Pressure Overload ◽  
Left Ventricular Pressure ◽  
Left Ventricular ◽  
Ventricular Pressure ◽  
Conscious Sheep

scholarly journals Determinants of Diastolic Dysfunction in Swine with HFpEF Arising From Transient Repetitive Left Ventricular Pressure Overload

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Brian R. Weil ◽  
Cody Smith ◽  
Christian G. Cavalieri ◽  
Rebeccah F. Young ◽  
Ruogang Zhao ◽  
...  
Keyword(s):  
Diastolic Dysfunction ◽  
Pressure Overload ◽  
Left Ventricular Pressure ◽  
Left Ventricular ◽  
Ventricular Pressure

scholarly journals Atrial Remodeling Is Directly Related to End-Diastolic Left Ventricular Pressure in a Mouse Model of Ventricular Pressure Overload

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e72651 ◽  
Author(s):  
Anne Margreet De Jong ◽  
Isabelle C. Van Gelder ◽  
Inge Vreeswijk-Baudoin ◽  
Megan V. Cannon ◽  
Wiek H. Van Gilst ◽  
...  
Keyword(s):  
Mouse Model ◽  
Pressure Overload ◽  
Left Ventricular Pressure ◽  
Left Ventricular ◽  
Ventricular Pressure ◽  
Atrial Remodeling

Progressive feline pressure-overload: noninvasive assessment correlates with abnormalities in single cells

1993 ◽  
Vol 264 (4) ◽  
pp. H1307-H1314 ◽  
Author(s):  
P. S. Pollack ◽  
B. A. Bailey ◽  
R. Budjak ◽  
E. Fernandez ◽  
S. R. Houser
Keyword(s):  
Myocardial Dysfunction ◽  
Single Cells ◽  
Pressure Overload ◽  
Left Ventricular Pressure ◽  
Left Ventricular ◽  
Septal Wall ◽  
Septal Wall Thickness ◽  
Feline Model ◽  
And Function ◽  
Fractional Shortening

Serial echocardiography and Doppler were used to monitor the progression of pressure-overload produced by banding the ascending aortas of young cats. The peak Doppler gradient across the band increased (as the animals grew in size) from 42 +/- 4.2 mmHg at 1 wk to 78 +/- 4.5 mmHg at 2-3 mos. Echocardiographic measurements of septal wall thickness increased significantly at 1 wk. Global ventricular function was unaltered in banded cats versus shams at each time point. However, in the subgroup of animals with an aortic-constricted area of < 0.025 cm2 at 1 wk, fractional shortening decreased by 40% at 2-3 mos. Contractile abnormalities were present in isolated myocytes from hypertrophied hearts. Mechanical function was more profoundly depressed in cells from hearts with echocardiographic evidence of ventricular decompensation. Echocardiographic and Doppler studies assessed cardiac size and function and identified indexes predictive of global and cellular myocardial dysfunction. The use of noninvasive techniques as a predictor of failure makes the feline model of progressive left ventricular pressure-overload useful for studies of cellular and molecular factors regulating not only the development of cardiac hypertrophy but also the transition from compensated hypertrophy to myocardial failure.

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