scholarly journals Influence of the Novel Inotropic Agent Levosimendan on Isometric Tension and Calcium Cycling in Failing Human Myocardium

Circulation ◽  
1998 ◽  
Vol 98 (20) ◽  
pp. 2141-2147 ◽  
Author(s):  
Gerd Hasenfuss ◽  
Burkert Pieske ◽  
Maria Castell ◽  
Bodo Kretschmann ◽  
Lars S. Maier ◽  
...  
Keyword(s):  
Isometric Tension ◽  
Human Myocardium ◽  
Inotropic Agent ◽  
The Novel ◽  
Calcium Cycling

Relationship Between Myocardial Function and Expression of Calcium Cycling Proteins in Nonfailing and Failing Human Myocardium

1995 ◽  
pp. 103-116
Author(s):  
Gerd Hasenfuss ◽  
Hans Reinecke ◽  
Roland Studer ◽  
Burkert Pieske ◽  
Markus Meyer ◽  
...  
Keyword(s):  
Myocardial Function ◽  
Human Myocardium ◽  
Calcium Cycling

Effect of NG-Monomethyl-l-Arginine on Endothelium-Dependent Relaxation of Human Subcutaneous Resistance Arteries

1990 ◽  
Vol 79 (3) ◽  
pp. 273-278 ◽  
Author(s):  
Robin G. Woolfson ◽  
Lucilla Poston
Keyword(s):  
Inhibitory Action ◽  
Contractile Response ◽  
Physiological Saline ◽  
Isometric Tension ◽  
The Novel ◽  
Resistance Arteries ◽  
Relaxing Factor ◽  
Endothelium Derived Relaxing Factor ◽  
Endothelium Dependent Relaxation ◽  
Stimulation Of

1. Using a myograph to measure isometric tension, we have looked at the action of NG-monomethyl-l-arginine on the endothelium-dependent relaxation of human subcutaneous resistance arteries. 2. NG-Monomethyl-l-arginine, the novel inhibitor of endothelium-derived relaxing factor synthesis, caused concentration-dependent but only partial inhibition of maximal relaxation induced by acetylcholine in human subcutaneous resistance arteries. 3. The inhibitory action of NG-monomethyl-l-arginine on acetylcholine-induced maximal relaxation was partially reversed by incubation of the arteries in equimolar concentrations of l-arginine and NG-monomethyl-l-arginine. Subsequent incubation in l-arginine led to further reversal, but this was no greater than with incubation in physiological saline. 4. A component of acetylcholine-induced relaxation was sensitive to indomethacin, suggesting that this response is mediated by prostanoids as well as by endothelium-derived relaxing factor. 5. NG-Monomethyl-l-arginine did not increase the tension of resting human subcutaneous resistance arteries. NG-Monomethyl-l-arginine did enhance the contractile response to noradrenaline, possibly due to inhibition of release of endothelium-derived relaxing factor resulting from stimulation of α2-adrenoreceptors on the endothelial cells.

Energetics of calcium cycling in nonfailing and failing human myocardium

1992 ◽  
pp. 81-92 ◽  
Author(s):  
G. Hasenfuss ◽  
L. A. Mulieri ◽  
C. Holubarsch ◽  
B. Pieske ◽  
H. Just ◽  
...  
Keyword(s):  
Human Myocardium ◽  
Calcium Cycling

Pharmacological Profile of the Novel Inotropic Agent (E,Z)-3-((2-Aminoethoxy)imino)androstane-6,17-dione Hydrochloride (PST2744)

2002 ◽  
Vol 303 (2) ◽  
pp. 592-600 ◽  
Author(s):  
R. Micheletti ◽  
G. G. Mattera ◽  
M. Rocchetti ◽  
A. Schiavone ◽  
M. F. Loi ◽  
...  
Keyword(s):  
Inotropic Agent ◽  
The Novel ◽  
Pharmacological Profile ◽  
Dione Hydrochloride

The Novel Anthracenedione, Pixantrone, Lacks Redox Activity and Inhibits Doxorubicinol Formation in Human Myocardium: Insight to Explain the Cardiac Safety of Pixantrone in Doxorubicin-Treated Patients

2012 ◽  
Vol 344 (2) ◽  
pp. 467-478 ◽  
Author(s):  
Emanuela Salvatorelli ◽  
Pierantonio Menna ◽  
Odalys Gonzalez Paz ◽  
Massimo Chello ◽  
Elvio Covino ◽  
...  
Keyword(s):  
Human Myocardium ◽  
Redox Activity ◽  
The Novel ◽  
Cardiac Safety

The novel steroidal glycoside from the dried bulb of Allium Macrostemon Bunge inhibits platelet activation

2010 ◽  
Vol 34 (8) ◽  
pp. S33-S33
Author(s):  
Wenchao Ou ◽  
Haifeng Chen ◽  
Yun Zhong ◽  
Benrong Liu ◽  
Keji Chen
Keyword(s):  
Platelet Activation ◽  
The Novel ◽  
Steroidal Glycoside ◽  
Allium Macrostemon
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