scholarly journals Regulation of Discoidin Domain Receptor 2 by Cyclic Mechanical Stretch in Cultured Rat Vascular Smooth Muscle Cells

Hypertension ◽  
2005 ◽  
Vol 46 (3) ◽  
pp. 614-621 ◽  
Author(s):  
Kou-Gi Shyu ◽  
Ya-Meng Chao ◽  
Bao-Wei Wang ◽  
Peiliang Kuan
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Mechanical Stretch ◽  
Discoidin Domain Receptor ◽  
Discoidin Domain Receptor 2

scholarly journals SIRT1 and FOXO Mediate Contractile Differentiation of Vascular Smooth Muscle Cells under Cyclic Stretch

2015 ◽  
Vol 37 (5) ◽  
pp. 1817-1829 ◽  
Author(s):  
Kai Huang ◽  
Zhi-Qiang Yan ◽  
Dan Zhao ◽  
Si-Guo Chen ◽  
Li-Zhi Gao ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Mechanical Stretch ◽  
Cyclic Stretch ◽  
Underlying Mechanisms

Background/Aims: Physiological mechanical stretch in vivo helps to maintain the quiescent contractile differentiation of vascular smooth muscle cells (VSMCs), but the underlying mechanisms are still unclear. Here, we investigated the effects of SIRT1 in VSMC differentiation in response to mechanical cyclic stretch. Methods and Results: Rat VSMCs were subjected to 10%-1.25Hz-cyclic stretch in vitro using a FX-4000T system. The data indicated that the expression of contractile markers, including α-actin, calponin and SM22α, was significantly enhanced in VSMCs that were subjected to cyclic stretch compared to the static controls. The expression of SIRT1 and FOXO3a was increased by the stretch, but the expression of FOXO4 was decreased. Decreasing SIRT1 by siRNA transfection attenuated the stretch-induced expression of contractile VSMC markers and FOXO3a. Furthermore, increasing SIRT1 by either treatment with activator resveratrol or transfection with a plasmid to induce overexpression increased the expression of FOXO3a and contractile markers, and decreased the expression of FOXO4 in VSMCs. Similar trends were observed in VSMCs of SIRT1 (+/-) knockout mice. The overexpression of FOXO3a promoted the expression of contractile markers in VSMCs, while the overexpression of FOXO4 demonstrated the opposite effect. Conclusion: Our results indicated that physiological cyclic stretch promotes the contractile differentiation of VSMCs via the SIRT1/FOXO pathways and thus contributes to maintaining vascular homeostasis.

Molecular basis of the effects of mechanical stretch on vascular smooth muscle cells

2007 ◽  
Vol 40 (5) ◽  
pp. 947-960 ◽  
Author(s):  
Jason H. Haga ◽  
Yi-Shuan J. Li ◽  
Shu Chien
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Molecular Basis ◽  
Muscle Cells ◽  
Mechanical Stretch

scholarly journals Activation of Cell Adhesion Kinase β by Mechanical Stretch in Vascular Smooth Muscle Cells

Endocrinology ◽  
2003 ◽  
Vol 144 (6) ◽  
pp. 2304-2310 ◽  
Author(s):  
Hiroaki Iwasaki ◽  
Takanobu Yoshimoto ◽  
Toru Sugiyama ◽  
Yukio Hirata
Keyword(s):  
Smooth Muscle ◽  
Cell Adhesion ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Mechanical Stretch

scholarly journals Chemokines protect vascular smooth muscle cells from cell death induced by cyclic mechanical stretch

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Jing Zhao ◽  
Yuhei Nishimura ◽  
Akihiko Kimura ◽  
Kentaro Ozawa ◽  
Toshikazu Kondo ◽  
...  
Keyword(s):  
Cell Death ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Mechanical Stretch

scholarly journals Study on effect of mechanical stretch on vascular smooth muscle cells

2007 ◽  
Vol 19 (Supplement) ◽  
pp. 100-100
Author(s):  
Yoshihiro Koyama ◽  
Hideki Kadozono ◽  
Hitoshi Kawato ◽  
Akinobu Inakuma ◽  
Keiichi Miyamoto ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Mechanical Stretch

scholarly journals Mechanical stretch induces the apoptosis regulator PUMA in vascular smooth muscle cells

2011 ◽  
Vol 93 (1) ◽  
pp. 181-189 ◽  
Author(s):  
Wen-Pin Cheng ◽  
Bao-Wei Wang ◽  
Shih-Chung Chen ◽  
Hang Chang ◽  
Kou-Gi Shyu
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Mechanical Stretch
Sign in / Sign up

Export Citation Format

Share Document