Nifedipine Prevents Renal Injury in Rats With Chronic Nitric Oxide Inhibition

Hypertension ◽  
1995 ◽  
Vol 26 (1) ◽  
pp. 150-155 ◽  
Author(s):  
Miriam Oliveira Ribeiro ◽  
Edson Antunes ◽  
Marcelo Nicolas Muscará ◽  
Gilberto De Nucci ◽  
Roberto Zatz
Keyword(s):  
Nitric Oxide ◽  
Renal Injury ◽  
Nitric Oxide Inhibition ◽  
Oxide Inhibition

scholarly journals Persistent hypertension and progressive renal injury induced by salt overload after short term nitric oxide inhibition

Clinics ◽  
2007 ◽  
Vol 62 (6) ◽  
pp. 749-756 ◽  
Author(s):  
Ana Lúcia Mattar ◽  
Flávia Gomes Machado ◽  
Clarice Kazue Fujihara ◽  
Denise Maria Avancini Costa Malheiros ◽  
Roberto Zatz
Keyword(s):  
Nitric Oxide ◽  
Renal Injury ◽  
Short Term ◽  
Nitric Oxide Inhibition ◽  
Oxide Inhibition

Role of angiotensin II in salt-induced increase in blood pressure and renal injury during chronic nitric oxide inhibition

1994 ◽  
Vol 1 ◽  
pp. 276
Author(s):  
Y. Konishi ◽  
M. Okamura ◽  
M. Nishimura ◽  
N. Negoro ◽  
T. Inoue ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Pressure ◽  
Angiotensin Ii ◽  
Renal Injury ◽  
Nitric Oxide Inhibition ◽  
Oxide Inhibition

Pathogenic role of innate immunity in a model of chronic NO inhibition associated with salt overload

2019 ◽  
Vol 317 (4) ◽  
pp. F1058-F1067 ◽  
Author(s):  
Fernanda Florencia Fregnan Zambom ◽  
Karin Carneiro Oliveira ◽  
Orestes Foresto-Neto ◽  
Viviane Dias Faustino ◽  
Victor Ferreira Ávila ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Innate Immunity ◽  
Uric Acid ◽  
Renal Injury ◽  
Interstitial Fibrosis ◽  
Experimental Models ◽  
Pyrrolidine Dithiocarbamate ◽  
Glomerular Injury ◽  
Nitric Oxide Inhibition ◽  
Oxide Inhibition

Nitric oxide inhibition with Nω-nitro-l-arginine methyl ester (l-NAME), along with salt overload, leads to hypertension, albuminuria, glomerulosclerosis, glomerular ischemia, and interstitial fibrosis, characterizing a chronic kidney disease (CKD) model. Previous findings of this laboratory and elsewhere have suggested that activation of at least two pathways of innate immunity, Toll-like receptor 4 (TLR4)/NF-κB and nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain containing 3 (NLRP3) inflammasome/IL-1β, occurs in several experimental models of CKD and that progression of renal injury can be slowed with inhibition of these pathways. In the present study, we investigated whether activation of innate immunity, through either the TLR4/NF-κB or NLRP3/IL-1β pathway, is involved in the pathogenesis of renal injury in chronic nitric oxide inhibition with the salt-overload model. Adult male Munich-Wistar rats that received l-NAME in drinking water with salt overload (HS + N group) were treated with allopurinol (ALLO) as an NLRP3 inhibitor (HS + N + ALLO group) or pyrrolidine dithiocarbamate (PDTC) as an NF-κB inhibitor (HS + N + PDTC group). After 4 wk, HS + N rats developed hypertension, albuminuria, and renal injury along with renal inflammation, oxidative stress, and activation of both the NLRP3/IL-1β and TLR4/NF-κB pathways. ALLO lowered renal uric acid and inhibited the NLRP3 pathway. These effects were associated with amelioration of hypertension, albuminuria, and interstitial inflammation/fibrosis but not glomerular injury. PDTC inhibited the renal NF-κB system and lowered the number of interstitial cells staining positively for NLRP3. PDTC also reduced renal xanthine oxidase activity and uric acid. Overall, PDTC promoted a more efficient anti-inflammatory and nephroprotective effect than ALLO. The NLRP3/IL-1β and TLR4/NF-κB pathways act in parallel to promote renal injury/inflammation and must be simultaneously inhibited for best nephroprotection.

Nitric Oxide Inhibition in the Rat Improves Blood Pressure and Renal Function During Hypovolemic Shock.

1991 ◽  
Author(s):  
Wilfred Lieberthal ◽  
Amy E. McGarry ◽  
James Sheils ◽  
C. R. Valeri
Keyword(s):  
Nitric Oxide ◽  
Blood Pressure ◽  
Renal Function ◽  
Hypovolemic Shock ◽  
Nitric Oxide Inhibition ◽  
Oxide Inhibition

Mechanism of nitric oxide inhibition in human jejunal smooth muscle

2000 ◽  
Vol 191 (4) ◽  
pp. S25-S26
Author(s):  
Nicholas J Zyromski ◽  
Judith A Duenes ◽  
Michael L Kendrick ◽  
Gianrico Farrugia ◽  
Michael G Sarr
Keyword(s):  
Nitric Oxide ◽  
Smooth Muscle ◽  
Nitric Oxide Inhibition ◽  
Oxide Inhibition

scholarly journals Regulation of renin release is impaired after nitric oxide inhibition

1996 ◽  
Vol 49 (3) ◽  
pp. 626-633 ◽  
Author(s):  
Christos Chatziantoniou ◽  
Marie-Dominique Pauti ◽  
Florence Pinet ◽  
Dominique Promeneur ◽  
Jean-Claude Dussaule ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Renin Release ◽  
Nitric Oxide Inhibition ◽  
Oxide Inhibition

P012 ASSESSMENT OF INTESTINAL PERMEABILITY AND INTERFERON-GAMA LEVELS AFTER NITRIC OXIDE INHIBITION IN ANIMALS SUPPLEMENTED WITH GLUTAMINE

2009 ◽  
Vol 4 (2) ◽  
pp. 30
Author(s):  
M.T.D. Correia ◽  
R.G.C. Santos ◽  
M.L. Viana ◽  
S.V. Generoso ◽  
J. Nogueira-Machado ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Intestinal Permeability ◽  
Nitric Oxide Inhibition ◽  
Oxide Inhibition
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