scholarly journals Angiotensin II Type 1 Receptor Blockade Prevents Cardiac Remodeling in Bradykinin B 2 Receptor Knockout Mice

Hypertension ◽  
2000 ◽  
Vol 35 (1) ◽  
pp. 391-396 ◽  
Author(s):  
Paolo Madeddu ◽  
Costanza Emanueli ◽  
Roberta Maestri ◽  
Maria Bonaria Salis ◽  
Alessandra Minasi ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Knockout Mice ◽  
Cardiac Remodeling ◽  
Receptor Blockade

scholarly journals Effect of Angiotensin II Type 1 Receptor Blockade on Cardiac Remodeling in Angiotensin II Type 2 Receptor Null Mice

2002 ◽  
Vol 22 (1) ◽  
pp. 49-54 ◽  
Author(s):  
Lan Wu ◽  
Masaru Iwai ◽  
Hironori Nakagami ◽  
Rui Chen ◽  
Jun Suzuki ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Cardiac Remodeling ◽  
Receptor Blockade

scholarly journals Modulation of Angiotensin II–Mediated Hypertension and Cardiac Remodeling by Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Deletion

Hypertension ◽  
2008 ◽  
Vol 52 (3) ◽  
pp. 556-562 ◽  
Author(s):  
Changping Hu ◽  
Abhijit Dandapat ◽  
Liuqin Sun ◽  
Muhammad R. Marwali ◽  
Nobutaka Inoue ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Knockout Mice ◽  
Cardiac Remodeling ◽  
Cardiac Fibroblasts ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Receptor Expression ◽  
Induced Hypertension ◽  
Density Lipoprotein Receptor

Angiotensin II via type 1 receptor activation upregulates the expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), and LOX-1 activation, in turn, upregulates angiotensin II type 1 receptor expression. We postulated that interruption of this positive feedback loop might attenuate the genesis of angiotensin II–induced hypertension and subsequent cardiac remodeling. To examine this postulate, LOX-1 knockout and wild-type mice were infused with angiotensin II or norepinephrine (control for angiotensin II) for 4 weeks. Angiotensin II–, but not norepinephrine-, induced hypertension was attenuated in LOX-1 knockout mice. Angiotensin II–induced cardiac remodeling was also attenuated in LOX-1 knockout mice. Importantly, angiotensin II type 1 receptor expression was reduced, and the expression and activity of endothelial NO synthase were preserved in the tissues of LOX-1 knockout mice given angiotensin II. Reactive oxygen species generation, nicotinamide-adenine dinucleotide phosphate oxidase expression, and phosphorylation of p38 and p44/42 mitogen-activated protein kinases were also much less pronounced in the LOX-1 knockout mice given angiotensin II. These alterations in biochemical and structural abnormalities were associated with preservation of cardiac hemodynamics in the LOX-1 knockout mice. To confirm that fibroblast function is modulated in the absence of LOX-1, cardiac fibroblasts from wild-type and LOX-1 knockout mice were treated with angiotensin II. Indeed, LOX-1 knockout mice cardiac fibroblasts revealed an attenuated profibrotic response on treatment with angiotensin II. These observations provide strong evidence that LOX-1 is a key modulator of the development of angiotensin II–induced hypertension and subsequent cardiac remodeling.

Angiotensin II Type 1 Receptor Blockade Inhibits the Expression of Immediate-Early Genes and Fibronectin in Rat Injured Artery

Circulation ◽  
1995 ◽  
Vol 92 (1) ◽  
pp. 88-95 ◽  
Author(s):  
Shokei Kim ◽  
Masaki Kawamura ◽  
Hideki Wanibuchi ◽  
Kensuke Ohta ◽  
Akinori Hamaguchi ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Immediate Early Genes ◽  
Immediate Early ◽  
Receptor Blockade ◽  
Early Genes ◽  
Injured Artery

Effects of angiotensin II type 1-receptor blockade on retinal endothelial function

2008 ◽  
Vol 26 (3) ◽  
pp. 516-522 ◽  
Author(s):  
Christian Ott ◽  
Markus P Schlaich ◽  
Joanna Harazny ◽  
Bernhard MW Schmidt ◽  
Georg Michelson ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Endothelial Function ◽  
Receptor Blockade

Angiotensin II Type 1 receptor blockade protects endothelium-derived hyperpolarising factor-mediated relaxation in a rat model of monoarthritis

Life Sciences ◽  
2013 ◽  
Vol 92 (23) ◽  
pp. 1131-1137 ◽  
Author(s):  
Andrew MacKenzie ◽  
Lynette Dunning ◽  
William R. Ferrell ◽  
John C. Lockhart
Keyword(s):  
Angiotensin Ii ◽  
Rat Model ◽  
Receptor Blockade

Postischemic apoptosis and functional recovery after angiotensin II type 1 receptor blockade in isolated working rat hearts

2001 ◽  
Vol 19 (6) ◽  
pp. 1121-1129 ◽  
Author(s):  
Rohit Moudgil ◽  
Vijayan Menon ◽  
Yi Xu ◽  
Sorin Musat-Marcu ◽  
Dinender Kumar ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Functional Recovery ◽  
Receptor Blockade ◽  
Rat Hearts
Sign in / Sign up

Export Citation Format

Share Document