scholarly journals Validity of the Xenon 133 Method for Measurement of Muscle Blood Flow Evaluated by Simultaneous Venous Occlusion Plethysmography

1965 ◽  
Vol 16 (3) ◽  
pp. 287-293 ◽  
Author(s):  
NIELS A. LASSEN ◽  
IB F. LINDBJERG ◽  
INGE DAHN
Keyword(s):  
Blood Flow ◽  
Muscle Blood Flow ◽  
Venous Occlusion ◽  
Venous Occlusion Plethysmography ◽  
Xenon 133

Peripheral blood flow during rewarming from mild hypothermia in humans

1985 ◽  
Vol 58 (1) ◽  
pp. 4-13 ◽  
Author(s):  
G. K. Savard ◽  
K. E. Cooper ◽  
W. L. Veale ◽  
T. J. Malkinson
Keyword(s):  
Blood Flow ◽  
Core Temperature ◽  
Skin Blood Flow ◽  
Cold Water ◽  
Mild Hypothermia ◽  
Muscle Blood Flow ◽  
Venous Occlusion ◽  
Warm Bath ◽  
Peripheral Blood Flow ◽  
Deep Body Temperature

During the initial stages of rewarming from hypothermia, there is a continued cooling of the core, or after-drop in temperature, that has been attributed to the return of cold blood due to peripheral vasodilatation, thus causing a further decrease of deep body temperature. To examine this possibility more carefully, subjects were immersed in cold water (17 degrees C), and then rewarmed from a mildly hypothermic state in a warm bath (40 degrees C). Measurements of hand blood flow were made by calorimetry and of forearm, calf, and foot blood flows by straingauge venous occlusion plethysmography at rest (Ta = 22 degrees C) and during rewarming. There was a small increase in skin blood flow during the falling phase of core temperature upon rewarming in the warm bath, but none in foot blood flow upon rewarming at room air, suggesting that skin blood flow seems to contribute to the after-drop, but only minimally. Limb blood flow changes during this phase suggest that a small muscle blood flow could also have contributed to the after-drop. It was concluded that the after-drop of core temperature during rewarming from mild hypothermia does not result from a large vasodilatation in the superficial parts of the periphery, as postulated. The possible contribution of mechanisms of heat conduction, heat convection, and cessation of shivering thermogenesis were discussed.

THE EFFECT OF LOCAL TEMPERATURE ON INDIRECT VASODILATATION IN THE FEET

1967 ◽  
Vol 45 (1) ◽  
pp. 63-73 ◽  
Author(s):  
Peter Gaskell ◽  
Garth M. Bray
Keyword(s):  
Blood Flow ◽  
Venous Occlusion ◽  
Venous Occlusion Plethysmography ◽  
Local Temperature ◽  
Cool Water ◽  
Arterial Blood

Lewis and Pickering reported in 1933 that warming occurred later in cool than in warm fingers in response to body heating. Factors which may be responsible were investigated. Measurement of rate of blood flow in the feet by venous occlusion plethysmography during body heating showed that vasodilatation in the feet occurred at the same time in a cool foot (18 to 23 °C) as in a warm (30 to 35 °C) but that warming of the cooler foot might be delayed for some time until the increase in flow was 0.5 ml/100 ml of foot per minute or more. In control experiments, with both feet in cool water or both in warm, the increase in blood flow during body heating started at the same time in both feet. Warming also began at the same time in both feet, but in the cool control experiments, warming often began later than did increase in flow. It is suggested that precooling of arterial blood may account for the delay in warming when the extremity is initially cool and the increase in blood flow is at first small during indirect vasodilatation.

scholarly journals Hyperglycemia Increases Muscle Blood Flow and Alters Endothelial Function in Adolescents with Type 1 Diabetes

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Amanda S. Dye ◽  
Hong Huang ◽  
John A. Bauer ◽  
Robert P. Hoffman
Keyword(s):  
Blood Flow ◽  
Type 1 Diabetes ◽  
Endothelial Function ◽  
Vascular Function ◽  
Microvascular Complications ◽  
Muscle Blood Flow ◽  
Arterial Occlusion ◽  
Venous Occlusion ◽  
Before And After

Alterations of blood flow and endothelial function precede development of complications in type 1 diabetes. The effects of hyperglycemia on vascular function in early type 1 diabetes are poorly understood. To investigate the effect of hyperglycemia on forearm vascular resistance (FVR) and endothelial function in adolescents with type 1 diabetes, FVR was measured before and after 5 minutes of upper arm arterial occlusion using venous occlusion plethysmography in (1) fasted state, (2) euglycemic state (~90 mg/dL; using 40 mU/m2/min insulin infusion), and (3) hyperglycemic state (~200 mg/dL) in 11 adolescents with type 1 diabetes. Endothelial function was assessed by the change in FVR following occlusion. Seven subjects returned for a repeat study with hyperglycemia replaced by euglycemia. Preocclusion FVR decreased from euglycemia to hyperglycemia (P=0.003). Postocclusion fall in FVR during hyperglycemia was less than during euglycemia (P=0.002). These findings were not reproduced when hyperglycemia was replaced with a second euglycemia. These results demonstrate that acute hyperglycemia causes vasodilation and alters endothelial function in adolescents with type 1 diabetes. In addition they have implications for future studies of endothelial function in type 1 diabetes and provide insight into the etiology of macrovascular and microvascular complications of type 1 diabetes.

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