scholarly journals A Pilot Study of Normobaric Oxygen Therapy in Acute Ischemic Stroke

Stroke ◽  
2005 ◽  
Vol 36 (4) ◽  
pp. 797-802 ◽  
Author(s):  
Aneesh B. Singhal ◽  
Thomas Benner ◽  
Luca Roccatagliata ◽  
Walter J. Koroshetz ◽  
Pamela W. Schaefer ◽  
...  
Stroke ◽  
2015 ◽  
Vol 46 (suppl_1) ◽  
Author(s):  
Aneesh B Singhal ◽  
Partners SPOTRIAS Investigators

BACKGROUND: There is little human data concerning the effect of hyperoxia on markers of oxidative stress after acute ischemic stroke (AIS); rodent studies show conflicting results. METHODS: In this NIH-SPOTRIAS Trial of normobaric oxygen therapy (NBO) in AIS, tPA-ineligible subjects with imaging-confirmed AIS < 9 hours and NIHSS score 4 or higher were randomized to NBO or Medical Air, delivered for 8 hrs. Of n=85 enrolled, we analyzed n=53 (24 NBO, 29 Air) who had NIHSS, oxidative stress biomarkers, and serial CT/MRI obtained at 0 hrs (admission/pre-therapy), 4 hrs (during therapy) and 48 hrs (post-therapy). RESULTS: At baseline, the NBO arm showed a trend for higher DWI lesion volumes (39.8±42 vs 20.3±20 cc, p=0.06), but there was no significant difference between NBO and Air for mean age (73±15y vs 74±14y, p=0.9), median NIHSS (11.5 vs. 9.0, p=0.5), or perfusion-MRI "mean transit time" lesion volumes (100.9 vs 74.3 cc, p=0.6). Pre-therapy antioxidant capacity, assessed with the oxygen radical absorbance capacity assay, was significantly lower in the NBO arm (p=0.02), suggestive of greater baseline oxidative stress associated with larger infarct volumes. Pre-therapy levels of the matrix metalloproteinases MMP-2 and MMP-9, and F2isoProstane (F2isoP, a direct marker of non-enzymatic oxidation of membrane phospholipids) were similar between groups. There was no significant change from 0-4 hours or from 0-48 hours in NIHSS scores, DWI volumes, and levels of MMP-2, MMP-9, and F2isoP (Table). The NBO and Air groups showed no significant differences in rates of tissue reperfusion, or indirect MRI markers of free radical injury such as stroke-related mass effect, brain hemorrhage, or the hyperacute reperfusion injury marker (HARM) sign. CONCLUSION: In patients with acute ischemic stroke, there is no significant change in direct and indirect markers of oxidative stress with hyperoxia therapy.


2021 ◽  
Vol 16 (6) ◽  
pp. 1017
Author(s):  
Xiao-Kun Geng ◽  
Yu-Chuan Ding ◽  
Zhe Cheng ◽  
Feng-Wu Li ◽  
ChristopherR Stone ◽  
...  

2016 ◽  
Vol 12 (2) ◽  
pp. 211-215
Author(s):  
Verónica V Olavarría ◽  
Hisatomi Arima ◽  
Craig S Anderson ◽  
Alejandro Brunser ◽  
Paula Muñoz-Venturelli ◽  
...  

Background The HEADPOST Pilot is a proof-of-concept, open, prospective, multicenter, international, cluster randomized, phase IIb controlled trial, with masked outcome assessment. The trial will test if lying flat head position initiated in patients within 12 h of onset of acute ischemic stroke involving the anterior circulation increases cerebral blood flow in the middle cerebral arteries, as measured by transcranial Doppler. The study will also assess the safety and feasibility of patients lying flat for ≥24 h. The trial was conducted in centers in three countries, with ability to perform early transcranial Doppler. A feature of this trial was that patients were randomized to a certain position according to the month of admission to hospital. Objective To outline in detail the predetermined statistical analysis plan for HEADPOST Pilot study. Methods All data collected by participating researchers will be reviewed and formally assessed. Information pertaining to the baseline characteristics of patients, their process of care, and the delivery of treatments will be classified, and for each item, appropriate descriptive statistical analyses are planned with comparisons made between randomized groups. For the outcomes, statistical comparisons to be made between groups are planned and described. Results This statistical analysis plan was developed for the analysis of the results of the HEADPOST Pilot study to be transparent, available, verifiable, and predetermined before data lock. Conclusions We have developed a statistical analysis plan for the HEADPOST Pilot study which is to be followed to avoid analysis bias arising from prior knowledge of the study findings. Trial registration The study is registered under HEADPOST-Pilot, ClinicalTrials.gov Identifier NCT01706094.


2003 ◽  
Vol 15 (3) ◽  
pp. 292
Author(s):  
D E Rusyniak ◽  
M A Kirk ◽  
J D May ◽  
L W Kao ◽  
E J Brizendine ◽  
...  

1989 ◽  
pp. 367-372 ◽  
Author(s):  
D. M. Rosenbaum ◽  
J. C. Grotta ◽  
F. M. Yatsu ◽  
C. M. Picone ◽  
L. C. Pettigrew ◽  
...  

JPRAS Open ◽  
2018 ◽  
Vol 18 ◽  
pp. 28-37
Author(s):  
Yusuke Hamamoto ◽  
Tomohisa Nagasao ◽  
Niyazi Aizezi ◽  
Motoki Tamai ◽  
Tetsukuni Kogure ◽  
...  

2019 ◽  
Vol 10 ◽  
Author(s):  
Jeannette Hofmeijer ◽  
Ruud van Kaam ◽  
Sarah E. Vermeer ◽  
Michel J. A. M. van Putten

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