scholarly journals Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia.

Stroke ◽  
1994 ◽  
Vol 25 (1) ◽  
pp. 165-170 ◽  
Author(s):  
G Yang ◽  
P H Chan ◽  
J Chen ◽  
E Carlson ◽  
S F Chen ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Cerebral Ischemia ◽  
Transgenic Mice ◽  
Reperfusion Injury ◽  
Focal Cerebral Ischemia ◽  
Copper Zinc Superoxide Dismutase ◽  
Zinc Superoxide Dismutase ◽  
Copper Zinc

Correlation between copper/zinc superoxide dismutase and the proliferation of neural stem cells in aging and following focal cerebral ischemia

2006 ◽  
Vol 104 (1) ◽  
pp. 129-136 ◽  
Author(s):  
Sunao Takemura ◽  
Takamasa Kayama ◽  
Atsushi Kuge ◽  
Hasmat Ali ◽  
Yasuaki Kokubo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stem Cells ◽  
Cerebral Ischemia ◽  
Transgenic Mice ◽  
Focal Cerebral Ischemia ◽  
Wild Type ◽  
Copper Zinc Superoxide Dismutase ◽  
Zinc Superoxide Dismutase ◽  
Transient Focal Cerebral Ischemia ◽  
Copper Zinc

Object Neural stem cells (NSCs) have been demonstrated in the subventricular zone (SVZ) of the lateral ventricle and the subgranular zone of the hippocampal dentate gyrus (DG). Although aging rats manifest a decrease in NSCs, rats exposed to stress (for example, ischemia, epilepsy, radiation, and trauma) show an increase in these cells. In transgenic mice, the overexpression of human copper/zinc superoxide dismutase (SOD1), an endogenous antioxidant, has been reported to be a protective enzyme against transient focal cerebral ischemia. The authors investigated the correlation between SOD1 and the proliferation of NSCs in aging as chronic oxidative stress (Experiment 1) and acute oxidative stress induced by transient focal cerebral ischemia (Experiment 2) in mice. Methods Bromodeoxyuridine (BrdU) was used in the evaluation of NSCs. In Experiment 1, NSCs in the SVZ significantly increased in 16-month-old transgenic mice compared with wild-type mice (p = 0.0001). In Experiment 2, mice were subjected to 30-minute occlusions of the middle cerebral artery. The increase in NSCs in the DG in transgenic mice was significantly greater than that in wild-type mice (p < 0.05). Conclusions Results in this study suggest that chronic and acute oxidative stress may inhibit the proliferation of NSCs and that SOD1 may play a key role in NSC proliferation.

Sign in / Sign up

Export Citation Format

Share Document