scholarly journals Evaluation of Cell Therapy on Exercise Performance and Limb Perfusion in Peripheral Artery Disease

Circulation ◽  
2017 ◽  
Vol 135 (15) ◽  
pp. 1417-1428 ◽  
Author(s):  
Emerson C. Perin ◽  
Michael P. Murphy ◽  
Keith L. March ◽  
Roberto Bolli ◽  
John Loughran ◽  
...  
Keyword(s):  
Cell Therapy ◽  
Peripheral Artery Disease ◽  
Exercise Performance ◽  
Peripheral Artery ◽  
Limb Perfusion ◽  
Artery Disease

scholarly journals Development of an Exercise Training Protocol to Investigate Arteriogenesis in a Murine Model of Peripheral Artery Disease

2019 ◽  
Vol 20 (16) ◽  
pp. 3956 ◽  
Author(s):  
Ayko Bresler ◽  
Johanna Vogel ◽  
Daniel Niederer ◽  
Daphne Gray ◽  
Thomas Schmitz-Rixen ◽  
...  
Keyword(s):  
Peripheral Artery Disease ◽  
Suitable Model ◽  
Peripheral Artery ◽  
Running Wheel ◽  
Limb Perfusion ◽  
Collateral Growth ◽  
Artery Disease ◽  
Set Up ◽  
Exercise Induced ◽  
And Control

Exercise is a treatment option in peripheral artery disease (PAD) patients to improve their clinical trajectory, at least in part induced by collateral growth. The ligation of the femoral artery (FAL) in mice is an established model to induce arteriogenesis. We intended to develop an animal model to stimulate collateral growth in mice through exercise. The training intensity assessment consisted of comparing two different training regimens in C57BL/6 mice, a treadmill implementing forced exercise and a free-to-access voluntary running wheel. The mice in the latter group covered a much greater distance than the former pre- and postoperatively. C57BL/6 mice and hypercholesterolemic ApoE-deficient (ApoE−/−) mice were subjected to FAL and had either access to a running wheel or were kept in motion-restricting cages (control) and hind limb perfusion was measured pre- and postoperatively at various times. Perfusion recovery in C57BL/6 mice was similar between the groups. In contrast, ApoE−/− mice showed significant differences between training and control 7 d postoperatively with a significant increase in pericollateral macrophages while the collateral diameter did not differ between training and control groups 21 d after surgery. ApoE−/− mice with running wheel training is a suitable model to simulate exercise induced collateral growth in PAD. This experimental set-up may provide a model for investigating molecular training effects.

Cell Therapy and Peripheral Artery Disease: Diabetics first!

2021 ◽  
Author(s):  
Bertrand Lehalle ◽  
Arnaud Dosda ◽  
Philippe Jan ◽  
Jean-François Stoltz
Keyword(s):  
Retrospective Study ◽  
Cell Therapy ◽  
Peripheral Artery Disease ◽  
Specific Problem ◽  
Foot Ulcers ◽  
Diabetic Patients ◽  
Clinical Expertise ◽  
Peripheral Artery ◽  
Arterial Revascularization ◽  
Artery Disease

Drawing on our clinical expertise with diabetic patients and on a retrospective study focused on patients with foot ulcers or wounds and Peripheral Artery Disease, we show a healing problem exists specifically in diabetic patients, despite arterial revascularization. To overcome this specific problem, Cell Therapy could be a way, exclusively aimed at diabetic patients. We explain the reasons why, as well as the ways and means, and more particularly the concept of tissue reversibility.

scholarly journals Phase I study of multi-gene cell therapy in patients with peripheral artery disease

2015 ◽  
Vol 21 (1) ◽  
pp. 21-32 ◽  
Author(s):  
P Michael Grossman ◽  
Emile R Mohler ◽  
Blake J Roessler ◽  
Robert L Wilensky ◽  
Bruce L Levine ◽  
...  
Keyword(s):  
Cell Therapy ◽  
Phase I ◽  
Peripheral Artery Disease ◽  
Phase I Study ◽  
Peripheral Artery ◽  
Artery Disease

scholarly journals PHASE I STUDY OF MULTI-GENE CELL THERAPY IN PATIENTS WITH PERIPHERAL ARTERY DISEASE

2012 ◽  
Vol 59 (13) ◽  
pp. E2073
Author(s):  
Paul Michael Grossman ◽  
Emile Mohler ◽  
Blake J. Roessler ◽  
Robert Wilensky ◽  
Bruce L. Levine ◽  
...  
Keyword(s):  
Cell Therapy ◽  
Phase I ◽  
Peripheral Artery Disease ◽  
Phase I Study ◽  
Peripheral Artery ◽  
Artery Disease

scholarly journals DUAL CT AND MRI IN VIVO TRACKING OF STEM CELL THERAPY IN PERIPHERAL ARTERY DISEASE

2010 ◽  
Vol 55 (10) ◽  
pp. A176.E1654
Author(s):  
Yibin Xie ◽  
Yingli Fu ◽  
Ronald Ouwerkerk ◽  
Steven M. Shea ◽  
Tina Ehtiati ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Therapy ◽  
Peripheral Artery Disease ◽  
Stem Cell Therapy ◽  
Peripheral Artery ◽  
Artery Disease ◽  
Ct And Mri
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