Cell Therapy and Peripheral Artery Disease: Diabetics first!

2021 ◽  
Author(s):  
Bertrand Lehalle ◽  
Arnaud Dosda ◽  
Philippe Jan ◽  
Jean-François Stoltz
Keyword(s):  
Retrospective Study ◽  
Cell Therapy ◽  
Peripheral Artery Disease ◽  
Specific Problem ◽  
Foot Ulcers ◽  
Diabetic Patients ◽  
Clinical Expertise ◽  
Peripheral Artery ◽  
Arterial Revascularization ◽  
Artery Disease

Drawing on our clinical expertise with diabetic patients and on a retrospective study focused on patients with foot ulcers or wounds and Peripheral Artery Disease, we show a healing problem exists specifically in diabetic patients, despite arterial revascularization. To overcome this specific problem, Cell Therapy could be a way, exclusively aimed at diabetic patients. We explain the reasons why, as well as the ways and means, and more particularly the concept of tissue reversibility.

scholarly journals The prognosis of diabetic patients with high ankle-brachial index depends on the coexistence of occlusive peripheral artery disease

2011 ◽  
Vol 53 (4) ◽  
pp. 984-991 ◽  
Author(s):  
Victor Aboyans ◽  
Philippe Lacroix ◽  
Minh-Hoang Tran ◽  
Claire Salamagne ◽  
Sophie Galinat ◽  
...  
Keyword(s):  
Peripheral Artery Disease ◽  
Ankle Brachial Index ◽  
Diabetic Patients ◽  
Peripheral Artery ◽  
Artery Disease

SCREENING OF PERIPHERAL ARTERY DISEASE AMONG HYPERTENSIVE AND DIABETIC PATIENTS

2018 ◽  
Vol 36 (Supplement 1) ◽  
pp. e281
Author(s):  
L. Maroda ◽  
A. Koncz ◽  
T. Kobling ◽  
M. Zrinyi ◽  
M. Semjeni ◽  
...  
Keyword(s):  
Peripheral Artery Disease ◽  
Diabetic Patients ◽  
Peripheral Artery ◽  
Artery Disease

scholarly journals High prevalence of exercise-induced ischemia in the asymptomatic limb of patients with apparently strictly unilateral symptoms and unilateral peripheral artery disease

2019 ◽  
Vol 13 ◽  
pp. 175394471881906 ◽  
Author(s):  
Samir Henni ◽  
Pascal Bauer ◽  
Tanguy Le Meliner ◽  
Jeanne Hersant ◽  
Xavier Papon ◽  
...  
Keyword(s):  
Pressure Drop ◽  
Peripheral Artery Disease ◽  
Systolic Pressure ◽  
Diabetic Patients ◽  
Peripheral Artery ◽  
Pressure Index ◽  
High Prevalence ◽  
Artery Disease ◽  
Exercise Induced ◽  
Brachial Systolic Pressure

Background: The prevalence of exercise-induced ischemia in the asymptomatic limb of patients with unilateral claudication based on history and treadmill evaluation, and with unilateral ipsilateral peripheral artery disease (i.e ankle-to-brachial systolic pressure index <0.90) is unknown. Methods: We detected exercise-induced ischemia in the asymptomatic limb of patients with apparently unilateral claudication. Among 6059 exercise-oximetry tests performed in 3407 nondiabetic and 961 diabetic patients. We estimated the intensity of ischemia in the both limb (buttocks and calves) using the lowest minimum value of the decrease from rest of oxygen pressure (DROP; limb changes minus chest changes from rest), with significant ischemia defined as DROP lower than −15 mmHg. Results: We found 152 tests performed in 142 nondiabetic patients and 40 tests performed in 38 diabetic patients. The asymptomatic limb showed significant ischemia in 46.7% and 37.5% of the tests. Strictly unilateral exercise-induced claudication with apparently unilateral peripheral artery disease was rare (<4% of all tests). However, among these highly selected tests, significant ischemia was found in the asymptomatic limb in more than one-third of cases. Conclusion: The asymptomatic limb of patients with peripheral artery disease should not be considered a normal limb.

scholarly journals Phase I study of multi-gene cell therapy in patients with peripheral artery disease

2015 ◽  
Vol 21 (1) ◽  
pp. 21-32 ◽  
Author(s):  
P Michael Grossman ◽  
Emile R Mohler ◽  
Blake J Roessler ◽  
Robert L Wilensky ◽  
Bruce L Levine ◽  
...  
Keyword(s):  
Cell Therapy ◽  
Phase I ◽  
Peripheral Artery Disease ◽  
Phase I Study ◽  
Peripheral Artery ◽  
Artery Disease

scholarly journals PHASE I STUDY OF MULTI-GENE CELL THERAPY IN PATIENTS WITH PERIPHERAL ARTERY DISEASE

2012 ◽  
Vol 59 (13) ◽  
pp. E2073
Author(s):  
Paul Michael Grossman ◽  
Emile Mohler ◽  
Blake J. Roessler ◽  
Robert Wilensky ◽  
Bruce L. Levine ◽  
...  
Keyword(s):  
Cell Therapy ◽  
Phase I ◽  
Peripheral Artery Disease ◽  
Phase I Study ◽  
Peripheral Artery ◽  
Artery Disease

scholarly journals Managing Peripheral Artery Disease in Diabetic Patients: A Questionnaire Survey from Vascular Centers of the Mediterranean Federation for the Advancing of Vascular Surgery (MeFAVS)

2020 ◽  
Vol 64 ◽  
pp. 239-245 ◽  
Author(s):  
Umberto Marcello Bracale ◽  
Raffaele Pio Ammollo ◽  
Emad A. Hussein ◽  
Jamal J. Hoballah ◽  
Olivier Goeau-Brissonniere ◽  
...  
Keyword(s):  
Vascular Surgery ◽  
Peripheral Artery Disease ◽  
Questionnaire Survey ◽  
Diabetic Patients ◽  
Peripheral Artery ◽  
The Mediterranean ◽  
Artery Disease
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