scholarly journals Oxidized Low-Density Lipoprotein Cholesterol Is Associated With Decreases in Cardiac Function Independent of Vascular Alterations

Hypertension ◽  
2008 ◽  
Vol 52 (3) ◽  
pp. 535-541 ◽  
Author(s):  
Ernst R. Rietzschel ◽  
Michel Langlois ◽  
Marc L. De Buyzere ◽  
Patrick Segers ◽  
Dirk De Bacquer ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein ◽  
Low Density Lipoprotein Cholesterol

scholarly journals Cardiac function in elderly inpatients in the recovery phase of rehabilitation: determining methods of treatment during the heart failure pandemic

2021 ◽  
Vol 24 (2) ◽  
Author(s):  
Hakuo Takahashi
Keyword(s):  
Heart Failure ◽  
Cardiac Function ◽  
Natriuretic Peptide ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Recovery Phase ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Elderly Inpatients

Objectives: This study aimed to evaluate cardiac function in elderly inpatients admitted to a recovery phase rehabilitation ward. N-terminal pro-B-type natriuretic peptide (NT-proBNP) was statistically analyzed, along with other laboratory and demographic variables. Methods: Laboratory parameters included NT-proBNP, serum albumin, hemoglobin (Hb), low-density lipoprotein cholesterol, hemoglobin A1c, and estimated glomerular filtration rate (eGFR). In addition, number of medications and trends in the use of cardiovascular agents were examined. Results: Four hundred fifty-seven patients were admitted throughout the year 2017 (188 men and 269 women, aged 83 ±10.1 years). The number of patients with NT-proBNP levels of more than 125, 400, and 900 pg/mL were 347 (75.9%), 204 (44.6%), and 109 (23.9%), respectively. The percentage of patients had been treated for hypertension, diabetes mellitus, and hypercholesterolemia were 51.8%, 20.5%, and 18.0%, respectively. N-terminal pro-B-type natriuretic peptide positively correlated with age (p=0.003), and negatively albumin (p<0.0000) and Hb (p=0.0000). Multiple regression analysis of NT-proBNP with age, albumin, eGFR, Hb, low-density lipoprotein cholesterol, and number of medications as independent variables revealed significant negative correlation only with albumin (p<0.0000) and eGFR (p<0.0000) independently. Conclusions: These results indicate that 3 out of 4 elderly inpatients in the recovery phase of rehabilitation are affected by chronic congestive heart failure, and management of nutrition is essential for prevention and progression of heart failure in this group.

scholarly journals The effects of long-term moderate exercise and Western-type diet on oxidative/nitrosative stress, serum lipids and cytokines in female Sprague Dawley rats

2021 ◽  
Author(s):  
Maria Donatella Semeraro ◽  
Gunter Almer ◽  
Melanie Kaiser ◽  
Sieglinde Zelzer ◽  
Andreas Meinitzer ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Serum Lipids ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein ◽  
Low Density Lipoprotein Cholesterol ◽  
High Fat ◽  
Nitric Oxide Metabolites

Abstract Purpose Regular exercise reduces obesity and the risk of cardiovascular disease. However, health-promoting benefits of physical activity are commonly associated with increased inflammation and oxidative stress. Here, we tested whether constant moderate exercise is able to prevent or attenuate the oxidative/nitrosative stress, inflammation, and serum lipids in lean and obese rats. Methods Four-month-old female Sprague Dawley rats received standard or a high-fat diet. Animals were subjected to a physical activity protocol, consisting of 30 min forced treadmill exercise for 5 consecutive days per week during 10 months. Baseline and sedentary (non-exercised) rats were used as controls. Lipids, oxidized low-density lipoprotein cholesterol, nitric oxide metabolites, and pro- and anti-inflammatory markers were measured in blood collected upon euthanasia. Results At variance to young baseline control rats, 14-month-old animals fed normal diet had increased plasma lipid levels, including total cholesterol and triglycerides, which were further elevated in rats that consumed a high-fat diet. While treadmill exercise did not lower the amount of serum lipids in standard diet group, forced physical activity reduced non-high-density lipoprotein cholesterol in response to high-fat diet feeding. Exercised rats fed standard diet or high-fat diet had lower abundancy of nitric oxide metabolites, which coincided with increased levels of oxidized low-density lipoprotein cholesterol. Accordingly, the amount of nitric oxide metabolites correlated inversely with oxidized low-density lipoprotein cholesterol and homo-arginine. Exercise significantly reduced inflammatory cytokines in high-fat diet fed rats only. Conclusion Our study suggests that regular exercise alters the equilibrium between oxidative and anti-oxidative compounds and reduces pro-inflammatory cytokines.

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