Peroxisome Proliferator-Activated Receptor-γ Activation With Angiotensin II Type 1 Receptor Blockade Is Pivotal for the Prevention of Blood-Brain Barrier Impairment and Cognitive Decline in Type 2 Diabetic Mice

Telmisartan Exerts Renoprotective Actions via Peroxisome Proliferator-Activated Receptor-γ/Hepatocyte Growth Factor Pathway Independent of Angiotensin II Type 1 Receptor Blockade

Hypertension ◽

10.1161/hypertensionaha.111.176263 ◽

2012 ◽

Vol 59 (2) ◽

pp. 308-316 ◽

Cited By ~ 33

Author(s):

Hiroshi Kusunoki ◽

Yoshiaki Taniyama ◽

Junya Azuma ◽

Kazuma Iekushi ◽

Fumihiro Sanada ◽

...

Keyword(s):

Angiotensin Ii ◽

Growth Factor ◽

Hepatocyte Growth Factor ◽

Peroxisome Proliferator ◽

Receptor Blockade ◽

Hepatocyte Growth

Faculty Opinions recommendation of Telmisartan exerts renoprotective actions via peroxisome proliferator-activated receptor-γ/hepatocyte growth factor pathway independent of angiotensin II type 1 receptor blockade.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13496958.14875060 ◽

2012 ◽

Author(s):

Alejandro Chade

Keyword(s):

Angiotensin Ii ◽

Growth Factor ◽

Hepatocyte Growth Factor ◽

Peroxisome Proliferator ◽

Receptor Blockade ◽

Hepatocyte Growth

401 TELMISARTAN PREVENTS COGNITIVE DECLINE IN TYPE 2 DIABETIC MICE WITH IMPROVEMENT OF BLOOD-BRAIN BARRIER DISRUPTION PARTLY DUE TO PPAR-GAMMA ACTIVATION

Journal of Hypertension ◽

10.1097/01.hjh.0000420250.96951.9b ◽

2012 ◽

Vol 30 ◽

pp. e118

Author(s):

Masaki Mogi ◽

Li-Juan Min ◽

Masachika Shudou ◽

Fei Jing ◽

Kana Tsukuda ◽

...

Keyword(s):

Cognitive Decline ◽

Blood Brain Barrier ◽

Ppar Gamma ◽

Diabetic Mice ◽

Gamma Activation ◽

Barrier Disruption ◽

Blood Brain Barrier Disruption ◽

Brain Barrier Disruption ◽

Angiotensin II Type 1 Receptor-Dependent Oxidative Stress Mediates Endothelial Dysfunction in Type 2 Diabetic Mice

Antioxidants and Redox Signaling ◽

10.1089/ars.2009.2831 ◽

2010 ◽

Vol 13 (6) ◽

pp. 757-768 ◽

Cited By ~ 41

Author(s):

Wing Tak Wong ◽

Xiao Yu Tian ◽

Aimin Xu ◽

Chi Fai Ng ◽

Hung Kay Lee ◽

...

Keyword(s):

Oxidative Stress ◽

Angiotensin Ii ◽

Endothelial Dysfunction ◽

Diabetic Mice ◽

Combination of a peroxisome proliferator-activated receptor-gamma agonist and an angiotensin II receptor blocker attenuates myocardial fibrosis and dysfunction in type 2 diabetic rats

Journal of Diabetes Investigation ◽

10.1111/jdi.12153 ◽

2013 ◽

Vol 5 (4) ◽

pp. 362-371 ◽

Cited By ~ 14

Author(s):

Chi Young Shim ◽

Byeong-Wook Song ◽

Min-Ji Cha ◽

Ki-Chul Hwang ◽

Sungha Park ◽

...

Keyword(s):

Angiotensin Ii ◽

Myocardial Fibrosis ◽

Diabetic Rats ◽

Receptor Blocker ◽

Angiotensin Ii Receptor Blocker ◽

Peroxisome Proliferator ◽

Angiotensin Ii Receptor ◽

Peroxisome proliferator-activated receptor (PPAR) α or γ does not change ischemic tolerance in hearts from type 2 diabetic mice

Journal of Molecular and Cellular Cardiology ◽

10.1016/s0022-2828(02)90735-2 ◽

2002 ◽

Vol 34 (6) ◽

pp. A3

Author(s):

Ellen Aasum ◽

Andrew Carley ◽

Terje S. Larsen ◽

David Lseverson

Keyword(s):

Ischemic Tolerance ◽

Peroxisome Proliferator ◽

Diabetic Mice ◽

Peroxisome proliferator-activated receptor α activation attenuated angiotensin type 1-mediated but enhanced angiotensin type 2-mediated hemodynamic effects to angiotensin II in the rat

Journal of Hypertension ◽

10.1097/hjh.0b013e3282f2f0f3 ◽

2008 ◽

Vol 26 (3) ◽

pp. 468-477 ◽

Cited By ~ 12

Author(s):

Tina Banks ◽

Adebayo Oyekan

Keyword(s):

Angiotensin Ii ◽

Peroxisome Proliferator ◽

Hemodynamic Effects ◽

Angiotensin Type

Increased inflammatory biomarkers in hypertensive type 2 diabetic patients: improvement after angiotensin II type 1 receptor blockade

Journal of the American Society of Hypertension ◽

10.1016/j.jash.2007.01.009 ◽

2007 ◽

Vol 1 (3) ◽

pp. 189-199 ◽

Cited By ~ 17

Author(s):

Rhian M. Touyz ◽

Carmine Savoia ◽

Ying He ◽

Dierk Endemann ◽

Qian Pu ◽

...

Keyword(s):

Angiotensin Ii ◽

Inflammatory Biomarkers ◽

Diabetic Patients ◽

Receptor Blockade ◽

Type 2 Diabetic Patients ◽

DPP-4 inhibition with alogliptin on top of angiotensin II type 1 receptor blockade ameliorates albuminuria via up-regulation of SDF-1^|^alpha; in type 2 diabetic patients with incipient nephropathy

Endocrine Journal ◽

10.1507/endocrj.ej13-0305 ◽

2014 ◽

Vol 61 (2) ◽

pp. 159-166 ◽

Cited By ~ 63

Author(s):

Hiroki Fujita ◽

Hisanori Taniai ◽

Hiroko Murayama ◽

Haruyo Ohshiro ◽

Hikaru Hayashi ◽

...

Keyword(s):

Angiotensin Ii ◽

Diabetic Patients ◽

Receptor Blockade ◽

Type 2 Diabetic Patients ◽

Incipient Nephropathy ◽

Possible synergistic effect of direct angiotensin II type 2 receptor stimulation by compound 21 with memantine on prevention of cognitive decline in type 2 diabetic mice

European Journal of Pharmacology ◽

10.1016/j.ejphar.2013.12.015 ◽

2014 ◽

Vol 724 ◽

pp. 9-15 ◽

Cited By ~ 22

Author(s):

Jun Iwanami ◽

Masaki Mogi ◽

Kana Tsukuda ◽

Fei Jing ◽

Kousei Ohshima ◽

...

Keyword(s):

Angiotensin Ii ◽

Synergistic Effect ◽

Cognitive Decline ◽

Diabetic Mice ◽

Receptor Stimulation ◽

Compound 21 ◽