scholarly journals Coronary Artery Aneurysms in Kawasaki Disease: Risk Factors for Progressive Disease and Adverse Cardiac Events in the US Population

2016 ◽  
Vol 5 (9) ◽  
Author(s):  
Kevin G. Friedman ◽  
Kimberly Gauvreau ◽  
Akiko Hamaoka‐Okamoto ◽  
Alexander Tang ◽  
Erika Berry ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery ◽  
Kawasaki Disease ◽  
Progressive Disease ◽  
Disease Risk ◽  
Cardiac Events ◽  
Coronary Artery Aneurysms ◽  
Adverse Cardiac Events ◽  
The Us

scholarly journals Association Between Serum Uric Acid Levels and Progression of Coronary Artery Calcification in Asian Population

2021 ◽  
Author(s):  
Yuki Ohmoto-Sekine ◽  
Makiko Ishihara ◽  
Kazuhisa Amakawa ◽  
Yumiko Ohike ◽  
Yasuji Arase
Keyword(s):  
Risk Factors ◽  
Uric Acid ◽  
Coronary Artery ◽  
Disease Risk ◽  
Lung Cancer Screening ◽  
Asian Population ◽  
Cardiac Events ◽  
History Of ◽  
Asymptomatic Subjects ◽  
Low Dose Computed Tomography

Abstract Background: Coronary artery calcium (CAC) is associated coronary heart disease risk. In addition, CAC progression is associated with worsening coronary atherosclerosis and predicts future cardiac events. We aimed to investigate risk factors for the progression of CAC in an asymptomatic Japanese population using low dose computed tomography (CT) lung cancer screening performed during routine health checkup.Methods: The risk factors for CAC progression were analyzed in 771 asymptomatic subjects who underwent repeated CAC measurement. Results: Of the 771 subjects, 632 (82.0%) were males with a mean age of 56 years old, 208 (27.0%) had a history of hypertension, 299 (38.8%) had dyslipidemia, 81 (10.5%) had diabetes mellitus, and 180 (23.3%) had hyperuricemia. During observation, 103 (13.4%) subjects had CAC progression, while 515 subjects (66.8%) showed no calcification. On multivariate analysis, increasing uric acid level was significantly associated with the progression of CAC (odds ratio 1.203, 95% confidence interval 1.045-1.387, P = 0.010).Conclusions: The results of this study show that hyperuricemia is associated with CAC progression in asymptomatic Japanese subjects.

Cardiac Events in Kawasaki Disease With Coronary Aneurysms Revisited, A Two-center Retrospective Cohort Study in Thailand

2021 ◽  
Author(s):  
Kanokvalee Santimahakullert ◽  
Chodchanok Vijarnsorn ◽  
Yuttapong Wongswadiwat ◽  
Prakul Chanthong ◽  
Sappaya Khrongsrattha ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Kawasaki Disease ◽  
Artery Bypass ◽  
Coronary Intervention ◽  
Ivig Treatment ◽  
Cardiac Events ◽  
Coronary Aneurysms ◽  
Adverse Cardiac Events ◽  
Percutaneous Coronary

Abstract Kawasaki disease (KD) is a common vasculitis in children, which may be complicated with coronary artery aneurysms (CAAs). We aimed to report the rates of major adverse cardiac events (MACE) and determine the risks of MACE in children diagnosed with KD and CAAs in Thailand. Data of 170 children diagnosed with KD and CAAs in two centers of Thailand between 1994 and 2019 was retrospectively reviewed. The risks of MACE were analyzed using multivariate analysis. Of 170 patients, forty-nine patients (28.8%) had giant CAAs. During the median time of follow-up (5.4 years; ranging from 22 days to 23 years), 19 patients (11.1%) experienced MACE including 12 coronary artery bypass grafting, 2 percutaneous coronary intervention and 5 patients with evidence of coronary occlusion. Coronary interventions were performed at 4 years (ranging from 0.01 to 9.5 years) after the KD diagnosis. Independent risks of MACE in KD with CAAs were from the presence of giant aneurysms (HR 16.55; 95% CI 2.52 to 108.63; p=0.003) and lack of intravenous immunoglobulin (IVIG) treatment (HR 11.43; 95% CI 2.8 to 46.62; p=0.001). The intervention-free rate at 5 and 10 years in patients with giant CAAs was 78.7% and 52.2%, respectively.Trial registration: TCTR20190125004

Epidemiology and Risk Factors for Giant Coronary Artery Aneurysms Identified After Acute Kawasaki Disease

2021 ◽  
Author(s):  
Hiroya Masuda ◽  
Ryusuke Ae ◽  
Taka-aki Koshimizu ◽  
Masami Matsumura ◽  
Koki Kosami ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery ◽  
Kawasaki Disease ◽  
Coronary Artery Aneurysms ◽  
Acute Kawasaki Disease

Cardiac events in Patients in their forties with Kawasaki disease and regression of coronary artery aneurysms

2020 ◽  
Vol 30 (12) ◽  
pp. 1821-1825 ◽  
Author(s):  
Etsuko Tsuda ◽  
Shuichi Yoneda ◽  
Yasuhide Asaumi ◽  
Atsuko Suzuki
Keyword(s):  
Coronary Artery ◽  
Kawasaki Disease ◽  
Coronary Arteries ◽  
Coronary Artery Calcification ◽  
Coronary Aneurysm ◽  
Coronary Artery Lesions ◽  
Cardiac Events ◽  
Coronary Artery Aneurysms ◽  
Coronary Aneurysms ◽  
Middle Aged Adult

AbstractOver a 50-year period from the first description of Kawasaki disease, we encountered three male patients with a history of Kawasaki disease, who had their first cardiac events in their forties. They were considered to have almost normal coronary arteries in the coronary angiograms when they were children and adolescents. They had no follow-up examinations after 20 years old. The 1st patient had an acute myocardial infarction, and the 2nd was a new appearance of coronary aneurysm and stenotic lesions with coronary artery calcification. The 3rd patient had unexpected sudden death. The interval from the onset of Kawasaki disease to the cardiac events ranged from 37 to 38 years. In the former two patients, coronary artery lesions could not be evaluated immediately after Kawasaki disease. Although the 3rd patient had bilateral medium-sized coronary artery aneurysms, his coronary aneurysms regressed 1 year after acute Kawasaki disease. The intimal thickening at a previous coronary aneurysm at the age of 19 was mild. The patients with regressed coronary aneurysms were asymptomatic for about 40 years after Kawasaki disease, prior to their cardiac events. Coronary artery calcification of the proximal portion of the major coronary arteries was a predictable marker in such patients. To prevent serious cardiac events in middle-aged adult patients, reevaluation of coronary artery lesions and restarting of anti-thrombotic therapy are needed. We must be aware that there are some differences in the clinical course and time of cardiac events between patients with giant aneurysms and those with medium aneurysms.

scholarly journals Incidentally identified coronary artery calcium on non-contrast CT scan of the chest predicts major adverse cardiac events among hospital inpatients

Open Heart ◽  
2021 ◽  
Vol 8 (2) ◽  
pp. e001695
Author(s):  
Christopher Yu ◽  
Austin C C Ng ◽  
Lloyd Ridley ◽  
Mekhala Anjaria ◽  
Silvan Meier ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Coronary Artery ◽  
Ct Scan ◽  
Cardiovascular Risk Factors ◽  
Coronary Artery Calcium ◽  
Cardiac Events ◽  
Adverse Cardiac Events ◽  
Contrast Ct ◽  
Hospital Inpatients

BackgroundCoronary artery calcium (CAC) identified on non-gated CT scan of the chest is predictive of major adverse cardiac events (MACE) in multiple studies with guidelines therefore recommending the routine reporting of incidental CAC. These studies have been limited however to the outpatient setting. We aimed to determine the prognostic utility of incidentally identified CAC on CT scan of the chest among hospital inpatients.Methods and resultsConsecutive patients (n=740) referred for inpatient non-contrast CT scan of the chest at a tertiary referral hospital (January 2011 to March 2017) were included (n=280) if they had no known history of coronary artery disease, active malignancy or died within 30 days of admission. Scans were assessed for the presence of CAC by visual assessment and quantified by Agatston scoring. Median age was 69 years (IQR: 54–82) and 51% were male with a median CAC score of 7 (IQR 0–205). MACE occurred in 140 (50%) patients at 3.5 years median follow-up including 98 deaths. Half of all events occurred within 18 months. Visible CAC was associated with increased MACE (HR) 6.0 (95% CI: 3.7 to 9.7) compared with patients with no visible CAC. This finding persisted after adjusting for cardiovascular risk factors HR 2.4 (95% CI: 1.3 to 4.3) and with both absolute CAC score and CAC score ≥50th percentile.ConclusionIncidental CAC identified on CT scan of the chest among hospital inpatients provides prognostic information that is independent of cardiovascular risk factors. These patients may benefit from aggressive risk factor modification given the high event rate in the short term.

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