Abstract 870: Cardiac Gene Therapy With Relaxin Receptor 1 Overexpression Protects Against Acute Myocardial Infarction and Associated Adverse Remodeling

2019 ◽  
Vol 125 (Suppl_1) ◽  
Author(s):  
Teja Devarakonda ◽  
Erik Kohlbrenner ◽  
Adolfo G Mauro ◽  
Chad Cain ◽  
Anindita Das ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Gene Therapy ◽  
Cardiac Gene ◽  
Adverse Remodeling ◽  
Relaxin Receptor

scholarly journals Incidence and Significance of Spontaneous ST Segment Re-elevation After Reperfused Anterior Acute Myocardial Infarction　― Relationship With Infarct Size, Adverse Remodeling, and Events at 1 Year―

2018 ◽  
Vol 82 (5) ◽  
pp. 1379-1386 ◽  
Author(s):  
Léo Cuenin ◽  
Sophie Lamoureux ◽  
Mathieu Schaaf ◽  
Thomas Bochaton ◽  
Jean-Pierre Monassier ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Infarct Size ◽  
St Segment ◽  
Adverse Remodeling

scholarly journals Eosinophil Deficiency Promotes Aberrant Repair and Adverse Remodeling Following Acute Myocardial Infarction

2020 ◽  
Vol 5 (7) ◽  
pp. 665-681 ◽  
Author(s):  
Iqbal S. Toor ◽  
Dominik Rückerl ◽  
Iris Mair ◽  
Rob Ainsworth ◽  
Marco Meloni ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Adverse Remodeling

scholarly journals Inflammation in myocardial injury: mesenchymal stem cells as potential immunomodulators

2019 ◽  
Vol 317 (2) ◽  
pp. H213-H225 ◽  
Author(s):  
Weiang Yan ◽  
Ejlal Abu-El-Rub ◽  
Sekaran Saravanan ◽  
Lorrie A. Kirshenbaum ◽  
Rakesh C. Arora ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Myocardial Injury ◽  
Significant Risk ◽  
Secondary Injury ◽  
Irreversible Loss ◽  
Mesenchymal Stem Cell Therapy ◽  
Number Of Patients ◽  
Adverse Remodeling

Ischemic heart disease is a growing worldwide epidemic. Improvements in medical and surgical therapies have reduced early mortality after acute myocardial infarction and increased the number of patients living with chronic heart failure. The irreversible loss of functional cardiomyocytes puts these patients at significant risk of ongoing morbidity and mortality after their index event. Recent evidence suggests that inflammation is a key mediator of postinfarction adverse remodeling in the heart. In this review, we discuss the cardioprotective and deleterious effects of inflammation and its mediators during acute myocardial infarction. We also explore the role of mesenchymal stem cell therapy to limit secondary injury and promote myocardial healing after myocardial infarction.

Sign in / Sign up

Export Citation Format

Share Document