Abstract TMP114: Oxidized Low Density Lipoprotein Predicts Recurrent Stroke in Patients With Minor Stroke or Transient Ischemic Attack

Stroke ◽  
2018 ◽  
Vol 49 (Suppl_1) ◽  
Author(s):  
Anxin Wang ◽  
Xia Meng ◽  
Yongjun Wang ◽  
Yilong Wang
Keyword(s):  
Transient Ischemic Attack ◽  
Recurrent Stroke ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Minor Stroke ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein ◽  
Ischemic Attack

Oxidized low-density lipoprotein predicts recurrent stroke in patients with minor stroke or TIA

Neurology ◽  
2018 ◽  
Vol 91 (10) ◽  
pp. e947-e955 ◽  
Author(s):  
Anxin Wang ◽  
Jie Xu ◽  
Guojuan Chen ◽  
David Wang ◽  
S. Claiborne Johnston ◽  
...  
Keyword(s):  
Proportional Hazards ◽  
Recurrent Stroke ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Cox Proportional Hazards ◽  
Minor Stroke ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein ◽  
Vascular Events ◽  
Secondary Outcomes

ObjectiveTo investigate the association between oxidized low-density lipoprotein (oxLDL) and recurrent stroke in patients with minor stroke or TIA.MethodsIn the Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events (CHANCE) trial, baseline oxLDL levels were blindly measured in plasma with the 4E6 antibody in the core laboratory. The primary outcome was any stroke within 90 days. The secondary outcomes included any stroke within 1 year and ischemic stroke and combined vascular events within 90 days and 1 year. The associations of oxLDL with recurrent stroke were analyzed by Cox proportional hazards.ResultsAmong 3,019 patients included in this study, the median (interquartile range) of oxLDL was 13.96 (6.65–28.81) μg/dL. After adjustment for conventional confounding factors, patients in the highest oxLDL quartile (≥28.81 μg/dL) had a higher risk of recurrent stroke within 90 days (hazard ratio 1.43, 95% confidence interval 1.03–1.98) compared to those in the lowest oxLDL quartile (<6.65 μg/dL). Similar results were found for secondary outcomes. We also found a J-shaped association between oxLDL and risk of each outcome. There were no significant interactions between oxLDL and low-density lipoprotein and use of dual antiplatelet, antihypertensive, antidiabetic, and statins agents.ConclusionsElevated oxLDL levels can independently predict recurrent stroke in patients with minor stroke or TIA.ClinicalTrials.gov identifier:NCT00979589.

Oxidized low-density lipoprotein (LDL) and LDL cholesterol are associated with outcomes of minor stroke and TIA

2020 ◽  
Vol 297 ◽  
pp. 74-80
Author(s):  
Anxin Wang ◽  
Liye Dai ◽  
Nan Zhang ◽  
Jinxi Lin ◽  
Guojuan Chen ◽  
...  
Keyword(s):  
Ldl Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Minor Stroke ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein

scholarly journals Effects of Intense Low-Density Lipoprotein Cholesterol Reduction in Patients With Stroke or Transient Ischemic Attack

Stroke ◽  
2007 ◽  
Vol 38 (12) ◽  
pp. 3198-3204 ◽  
Author(s):  
Pierre Amarenco ◽  
Larry B. Goldstein ◽  
Michael Szarek ◽  
Henrik Sillesen ◽  
Amy E. Rudolph ◽  
...  
Keyword(s):  
Transient Ischemic Attack ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Cholesterol Reduction ◽  
Low Density Lipoprotein Cholesterol ◽  
Ischemic Attack
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