scholarly journals Can We Remember Future Actions yet Forget the Last Two Minutes? Study in Transient Global Amnesia

2011 ◽  
Vol 23 (12) ◽  
pp. 4138-4149 ◽  
Author(s):  
Mathieu Hainselin ◽  
Peggy Quinette ◽  
Béatrice Desgranges ◽  
Olivier Martinaud ◽  
Didier Hannequin ◽  
...  
Keyword(s):  
Episodic Memory ◽  
Executive Functions ◽  
Memory Task ◽  
Transient Global Amnesia ◽  
Abrupt Onset ◽  
Memory Deficit ◽  
Clinical Syndrome ◽  
Clinical Consequences ◽  
Global Amnesia ◽  
The Impact

Transient global amnesia (TGA) is a clinical syndrome characterized by the abrupt onset of a massive episodic memory deficit that spares other cognitive functions. If the anterograde dimension is known to be impaired in TGA, researchers have yet to investigate prospective memory (PM)—which involves remembering to perform an intended action at some point in the future—in this syndrome. Furthermore, as executive functions are thought to be spared in this syndrome, TGA provides an opportunity to examine the impact of a massive “pure” memory impairment on PM. We assessed 38 patients with a newly designed protocol that distinguished between the prospective (remembering to do something at the appropriate time) and retrospective (remembering what has to be done) components of PM. Moreover, we investigated episodic memory with an anterograde memory task and assessed executive functions, anxiety and mood, as well as their links with PM. We demonstrated that PM is impaired during TGA, with a greater deficit for the retrospective component than for the prospective component. Furthermore, we highlighted a strong link between these two components. Anterograde episodic memory impairments were correlated with retrospective component deficits in TGA patients, although we were able to confirm that executive functions are globally spared. We discuss this pattern of results within the theoretical framework of PM, putting forward new arguments in favor of the idea that PM deficits can occur mainly because of a massive anterograde memory deficit. The clinical consequences of PM impairment in TGA are examined.

scholarly journals Persistent Retrograde Memory Deficit After Transient Global Amnesia

Cortex ◽  
1980 ◽  
Vol 16 (3) ◽  
pp. 509-518 ◽  
Author(s):  
Gustavo Roman-Campos ◽  
Charles M. Poser ◽  
Frank B. Wood
Keyword(s):  
Transient Global Amnesia ◽  
Memory Deficit ◽  
Retrograde Memory ◽  
Global Amnesia

097 A rare case of recurrent transient global amnesia

2018 ◽  
Vol 89 (6) ◽  
pp. A38.3-A39
Author(s):  
Sameer Saleem ◽  
Ronak Patel ◽  
Yash Gawarikar
Keyword(s):  
Transient Global Amnesia ◽  
Anterograde Amnesia ◽  
Epileptic Activity ◽  
Sudden Onset ◽  
Clinical Syndrome ◽  
Slice Thickness ◽  
Diagnostic Dilemma ◽  
Monthly Basis ◽  
Neurology Clinic ◽  
Global Amnesia

IntroductionTransient global amnesia (TGA) is a clinical syndrome characterised by the sudden onset of anterograde amnesia accompanied by repetitive questioning, sometimes with a retrograde component, lasting up to 24 hours, without compromise of other neurologic functions.CaseA 71 year old male presented to the neurology clinic with history of recurrent episodes of reversible anterograde amnesia with repetitive questioning. His first two episodes were in May 2016 and clinically very typical of TGA. After that he had recurrent episodes and he noted that they were happening on a monthly basis. He had an episode on 24 March 2017 at Yangon airport as he was returning from a trip to Myanmar. He had had three episodes in February 2017 and two in March and April 2017 and one episode on 20 May 2017. Initial MRI brain showed frontotemporal atrophy suggestive of Alzheimer’s disease and there was hypo-perfusion on the nuclear medicine study. EEG did not show any epileptic activity. His partner described a typical episode where the patient lost his memory for the preceding 24 hours and he had repetitive questioning such as ”what day is it” repeatedly. During the entire episode, he was conscious and able to converse appropriately. He had another episode of amnesia on 19 August and was admitted and underwent an MRI of brain, which showed characteristic punctate abnormalities in the bilateral hippocampi on B2000 DWI.ConclusionThe estimated annual rate of recurrence of TGA is 5.8%. Diagnosis is made from typical clinical features and typical MRI DWI findings of punctate lesions in the hippocampal with a DWI resolution of B=2000, and a thin slice thickness of 2 to 3 mm. Our patient had 11 documented episodes of transient amnesia and was a diagnostic dilemma until the characteristic hippocampal abnormalities were demonstrated on MRI.

scholarly journals Memory and Cerebral Blood Flow in Cases of Transient Global Amnesia During and After the Attack

1995 ◽  
Vol 8 (2) ◽  
pp. 93-101 ◽  
Author(s):  
H. Kazui ◽  
H. Tanabe ◽  
M. Ikeda ◽  
Y. Nakagawa ◽  
J. Shiraishi ◽  
...  
Keyword(s):  
Episodic Memory ◽  
Temporal Lobe ◽  
Photon Emission ◽  
Transient Global Amnesia ◽  
Procedural Memory ◽  
Procedural Learning ◽  
Priming Effects ◽  
Skill Test ◽  
Anatomical Basis ◽  
Global Amnesia

We administered various memory tests and neuroimaging examinations to four pure cases who met Hodges' clinical criteria for transient global amnesia (TGA), during and after the attack. The purpose of the present study was to determine whether procedural learning is acquired during TGA and whether priming effects are preserved during TGA, and to investigate the anatomical basis of various memory subcomponents through these cases. Episodic memory was severely disturbed only during TGA, consistent with previous studies. Procedural learning during TGA examined by a drawing skill test and a reading skill test developed by us, and the Tower of Toronto, was preserved during TGA, consistent with one earlier report dealing with procedural memory during TGA. Priming effects during TGA have never been assessed. A word completion priming task with Kanji letters developed by us demonstrated that priming effects were preserved during TGA. Neuroradiologically, single photon emission computed tomograph hippocampal images clearly revealed a hypoperfusion confined to the medial portion of the bilateral temporal lobe only during the attack. These findings indicate that the medial portion of the temporal lobe is important for episodic memory as described in previous reports, but did not play an important role in procedural memory and priming effects.

Transient global amnesia (TGA): concomitant episodic memory and PET assessment in two additional patients

NeuroImage ◽  
2001 ◽  
Vol 13 (6) ◽  
pp. 680
Author(s):  
Bérengère Guillery ◽  
Béatrice Desgranges ◽  
Vincent de la Sayette ◽  
Brigitte Landeau ◽  
Guy Perchey ◽  
...  
Keyword(s):  
Episodic Memory ◽  
Transient Global Amnesia ◽  
Global Amnesia

The relationship between working memory and episodic memory disorders in transient global amnesia

2006 ◽  
Vol 44 (12) ◽  
pp. 2508-2519 ◽  
Author(s):  
Peggy Quinette ◽  
Bérengère Guillery-Girard ◽  
Audrey Noël ◽  
Vincent de la Sayette ◽  
Fausto Viader ◽  
...  
Keyword(s):  
Working Memory ◽  
Episodic Memory ◽  
Transient Global Amnesia ◽  
Memory Disorders ◽  
Global Amnesia ◽  
The Relationship

scholarly journals How to forget a “traumatic” experience: a case report of transient global amnesia after nasopharyngeal swab for Coronavirus disease 19

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Sabrina Ravaglia ◽  
Antonio Zito ◽  
Lara Ahmad ◽  
Isabella Canavero
Keyword(s):  
Short Term Memory ◽  
Brain Mri ◽  
Memory Loss ◽  
Transient Global Amnesia ◽  
Clinical Syndrome ◽  
Traumatic Experience ◽  
Nasopharyngeal Swab ◽  
Medical Procedures ◽  
Diffusion Weight Image ◽  
Global Amnesia

Abstract Background Transient global amnesia (TGA) is a clinical syndrome characterized by a temporary short-term memory loss with inability to retain new memories, usually lasting 2 to 8 h. TGA may be related to several medical procedures, including angiography, general anesthesia, gastroscopy. Case presentation We report a 58-year-old woman who experiencing TGA one hour after the execution of her first-time nasopharyngeal swab for COVID-19. Brain MRI showed a typical punctate Diffusion Weight Image (DWI) hippocampal lesion. Conclusions This is the first report of TGA after the execution of nasopharyngeal swab for COVID-19. This association lengthen the list of medical procedures associated with TGA, and we discuss the possible plausible mechanisms by which a nasopharyngeal swab could trigger TGA.

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