Protection of Hyperoxia-Induced Neonatal Lung Injury by Parenterally Administered Bone Marrow–Derived Mesenchymal Stem Cells (BMMSCs).

2009 ◽  
Author(s):  
P Guo ◽  
JS Torday ◽  
VK Rehan
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Lung Injury ◽  
Neonatal Lung ◽  
Neonatal Lung Injury

Preconditioning Enhances the Paracrine Effect of Mesenchymal Stem Cells in Preventing Oxygen-Induced Neonatal Lung Injury in Rats

2012 ◽  
Vol 21 (15) ◽  
pp. 2789-2797 ◽  
Author(s):  
Paul Waszak ◽  
Rajesh Alphonse ◽  
Arul Vadivel ◽  
Lavinia Ionescu ◽  
Farah Eaton ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Lung Injury ◽  
Paracrine Effect ◽  
Neonatal Lung ◽  
Neonatal Lung Injury

scholarly journals Airway Delivery of Mesenchymal Stem Cells Prevents Arrested Alveolar Growth in Neonatal Lung Injury in Rats

2009 ◽  
Vol 180 (11) ◽  
pp. 1131-1142 ◽  
Author(s):  
Timothy van Haaften ◽  
Roisin Byrne ◽  
Sebastien Bonnet ◽  
Gael Y. Rochefort ◽  
John Akabutu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Lung Injury ◽  
Neonatal Lung ◽  
Neonatal Lung Injury

scholarly journals Therapeutic Effects of Bone Marrow-Derived Mesenchymal Stem Cells in Models of Pulmonary and Extrapulmonary Acute Lung Injury

2015 ◽  
Vol 24 (12) ◽  
pp. 2629-2642 ◽  
Author(s):  
Ling Liu ◽  
Hongli He ◽  
Airan Liu ◽  
Jingyuan Xu ◽  
Jibin Han ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Therapeutic Effects

microRNA-265 Regulates Bone Marrow Mesenchymal Stem Cells Differentiation and Promotes Sepsis Lung Injury Repair via Transforming Growth Factor Beta 1

2022 ◽  
Vol 12 (2) ◽  
pp. 405-410
Author(s):  
Lian Tan ◽  
Xiongxiong Wang ◽  
Danqi Chen ◽  
Li Xu ◽  
Yudong Xu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Lung Injury ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Alveolar Type ◽  
Injury Repair ◽  
Qrt Pcr ◽  
Marrow Mesenchymal Stem Cells

Our study investigates whether miR-265 regulates the differentiation of rat bone marrow mesenchymal stem cells (BMSCs) into alveolar type II epithelial cells (ATII) through TGF-β1 and promotes lung injury repair in rats with sepsis, thereby inhibiting sepsis progression. 25 patients with sepsis admitted to the Respiratory and Critical Care Medicine Department of the hospital and 17 normal controls were included. TGF-β1 level was measured by ELISA. miR-265 level was measured by qRT-PCR and AT II-related genes and proteins expression was analyzed by western blot and qRT-PCR. miR-265 expression was significantly higher in sepsis patients than normal group. Progenitor BMSCs were long and shuttle-shaped after 1 and 3 days of growth. Cultured MSCs had low expression of the negative antigen CD34 (4.32%) and high expression of the positive antigen CD44 (99.87%). TGF-β1 level was significantly increased with longer induction time, while miR-265 expression was significantly decreased in cell culture medium. miR-265 interference significantly decreased TGF-β1 expression. In conclusion, miR-265 inhibits BMSC differentiation to AT II via regulation of TGF-β1, thereby inhibiting sepsis progression.

scholarly journals Therapeutic effects of bone marrow-derived mesenchymal stem cells on radiation-induced lung injury

2015 ◽  
Vol 35 (2) ◽  
pp. 731-738 ◽  
Author(s):  
CHENGCHENG XIA ◽  
PENGYU CHANG ◽  
YUYU ZHANG ◽  
WEIYAN SHI ◽  
BIN LIU ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Lung Injury ◽  
Therapeutic Effects ◽  
Radiation Induced
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