scholarly journals Clinical significance of human intestinal spirochetosis

2020 ◽  
Vol 96 (1) ◽  
pp. 72-74
Author(s):  
Naoki Ogiwara ◽  
Chie Inomoto ◽  
Masashi Yokota ◽  
Erika Teramura ◽  
Yoshitaka Arase ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Intestinal Spirochetosis ◽  
Human Intestinal Spirochetosis

scholarly journals Human intestinal spirochetosis in Japan; its incidence, clinicopathologic features, and genotypic identification

2007 ◽  
Vol 21 (2) ◽  
pp. 76-84 ◽  
Author(s):  
Jin Tanahashi ◽  
Tsutomu Daa ◽  
Ayako Gamachi ◽  
Kenji Kashima ◽  
Yoshiyuki Kondoh ◽  
...  
Keyword(s):  
Clinicopathologic Features ◽  
Intestinal Spirochetosis ◽  
Human Intestinal Spirochetosis ◽  
Genotypic Identification

High Prevalence of Abnormal Colonoscopical Findings in Human Intestinal Spirochetosis

2009 ◽  
Vol 69 (5) ◽  
pp. AB299
Author(s):  
Masaaki Higashiyama ◽  
Sho Ogata ◽  
Yoshikazu Adachi ◽  
Junichiro Nishiyama ◽  
Koji Matsuzaki ◽  
...  
Keyword(s):  
Intestinal Spirochetosis ◽  
High Prevalence ◽  
Human Intestinal Spirochetosis

Human intestinal spirochetosis diagnosed with colonoscopy and analysis of partial 16S rDNA sequences of involved spirochetes

2001 ◽  
Vol 2 (1) ◽  
pp. 111-116 ◽  
Author(s):  
Wolfgang Kraatz ◽  
Ulf Thunberg ◽  
Bertil Pettersson ◽  
Claes Fellström
Keyword(s):  
16S Rdna ◽  
Type Strain ◽  
Sequence Similarity ◽  
Rdna Sequences ◽  
Intestinal Spirochetosis ◽  
16S Rdna Sequences ◽  
Pcr Products ◽  
Human Intestinal Spirochetosis ◽  
Type Strains ◽  
Rrna Sequences

AbstractDNA was extracted from colonic biopsies of 33 patients with and three without evidence of intestinal spirochetosis (IS) in the large bowel. The biopsies were subjected to PCR. A pair of primers, generating a 207 bp fragment, were designed to detect specifically the 16S rDNA gene ofBrachyspira. PCR products of the expected size were obtained from 33 samples with histologic evidence of IS. The PCR amplicons were used for sequencing. The sequences obtained were aligned to the corresponding 16S rRNA sequences of five type strains ofBrachyspira. The sequences of 23 PCR products were 99–100% identical with the correspond-ingB.aalborgitype strain sequence. Two cases showed 99–100% sequence similarity with the type strain ofB.pilosicoliP43/6/78. Six cases could not be referred to any of the known species ofBrachyspira. Two PCR products gave incomplete sequences.

scholarly journals Mucosal eosinophilic infiltration may be a characteristic of human intestinal spirochetosis

2021 ◽  
Author(s):  
Sho Ogata ◽  
Ken Shimizu ◽  
Susumu Tominaga ◽  
Susumu Matsukuma
Keyword(s):  
Medical Center ◽  
Eosinophilic Infiltration ◽  
Host Reaction ◽  
Inflammatory Reactions ◽  
Intestinal Spirochetosis ◽  
Neoplastic Lesions ◽  
Infection Parameters ◽  
Intestinal Symptoms ◽  
Human Intestinal Spirochetosis ◽  
Inflammation Parameters

Abstract Background: Human intestinal spirochetosis (HIS) is an infectious disease of large intestines caused by Brachyspira species, and most HIS cases are asymptomatic or exhibit mild intestinal symptoms. The host reaction to HIS remains unclear, and we examined HIS-related mucosal inflammatory features histologically. Method: From the archival HIS cases in a single medical center, 24 endoscopically taken specimens from 14 HIS cases (M:F = 10:4; 28-73 yrs) were selected as not containing polypoid or neoplastic lesions. Stromal neutrophils, eosinophils, and mast cells, and intraepithelial neutrophils and eosinophils, (sNeu, sEo, sMast, iNeu, and iEo, respectively) were counted, and the presence or absence of lymphoid follicles/aggregates (LFs) was also examined. Association of the above inflammation parameters and spirochetal infection parameters (such as degrees of characteristic fringe distribution, of spirochetal cryptal invasion, and of spirochetal intraepithelial invasion) were also analysed. Results: iNeu was observed in 29.2%, iEo in 58.3%, and LFs in 50.0% of the specimens. Maximal counts of sNeu, sEo, sMast, iNeu, and iEo averaged 8.4, 21.5, 6.0, 0.5 and 1.5, respectively. Strong correlation between the maximum counts of iNeu and iEo (p < 0.001, r = 0.81), and correlations between those of iEo and sNeu (p = 0.0012, r = 0.62) and between those of iEo and sEo (p = 0.026, r = 0.45) were observed. iNeu was influenced by fringe formation (p < 0.05) and spirochetal crypt involvement (p < 0.05). Conclusions: HIS was accompanied by inflammatory reactions, and among these, mucosal eosinophilic infiltration may be a central indicator and host reaction of HIS.

Histologic characteristics of human intestinal spirochetosis in operatively resected specimens

2020 ◽  
Vol 477 (1) ◽  
pp. 57-63
Author(s):  
Sho Ogata ◽  
Ken Shimizu ◽  
Susumu Tominaga ◽  
Kuniaki Nakanishi
Keyword(s):  
Intestinal Spirochetosis ◽  
Human Intestinal Spirochetosis
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