scholarly journals Determination of in Vitro Antiviral Activity of Nerium Oleander Distillate against to Parainfluenza-3 Virus

2014 ◽  
Vol 2 (5) ◽  
pp. 150 ◽  
Author(s):  
Oguzhan Avci
Keyword(s):  
Antiviral Activity ◽  
Nerium Oleander

Aryl-Substituted and Benzo-Annulated CycloSal-Derivatives of 2′,3′-Dideoxy-2′,3′-Didehydrothymidine Monophosphate — Correlation of Structure, Hydrolysis Properties and Anti-HIV Activity

2002 ◽  
Vol 13 (2) ◽  
pp. 129-141 ◽  
Author(s):  
Christian Ducho ◽  
Jan Balzarini ◽  
Lieve Naesens ◽  
Erik De Clercq ◽  
Chris Meier
Keyword(s):  
Antiviral Activity ◽  
Degradation Products ◽  
Hydrolytic Stability ◽  
Substitution Pattern ◽  
Cell Extracts ◽  
Hydrolysis Process ◽  
The Stability ◽  
Anti Hiv

The synthesis of phenyl-substituted and benzo-annulated cycloSal phosphate triesters of the nucleoside analogue 2′,3′-dideoxy-2′,3′-didehydrothymidine (d4T, Zerit™) as lipophilic, membrane-soluble pronucleotides is described. The cycloSal moiety was introduced by using cyclic chlorophosphite agents prepared from phenyl-substituted saligenin derivatives and orthohydroxymethylated naphthols, respectively. Hydrolysis studies (HPLC analysis) of the triesters 2, 3 showed a range of hydrolytic stability from 1.4 h up to 5.1 h and the stability could be correlated with the substitution pattern in the cycloSal moiety. A slight decrease of their stability was observed, if phenyl-substituted derivatives were hydrolyzed in human CEM/O cell extracts. D4T and thymine, possible products of enzymatic cleavage of the pronucleotides, were not detected in the cell extracts. A further investigation of the hydrolysis process was performed by 31P-NMR spectroscopy. This technique allowed a precise monitoring of the degradation products and the exact determination of the product ratio. Finally, the newly synthesized compounds were tested concerning their antiviral activity against HIV in vitro. A strong correlation of the hydrolysis properties and the antiviral activity was found. 3-phenyl- cycloSal-d4TMP showed a threefold increase in its anti-HIV-1 activity and retained full activity in thymidine kinase (TK) deficient cells, indicative of a successful TK-bypass.

In vitro determination of antiviral activity of MS8209, a new amphotericin B derivative, against primary isolates of HTV1

1996 ◽  
Vol 147 (5) ◽  
pp. 313-318 ◽  
Author(s):  
M. Magierowska-Jung ◽  
D. Cefaï ◽  
H. Marrakchi ◽  
F. Chieze ◽  
H. Agut ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Amphotericin B

scholarly journals Callus induction from Nerium oleander leaves and qualitative determination of some active compounds in vivo and in vitro

2013 ◽  
Vol 7 (3) ◽  
pp. 12-17
Author(s):  
Liqa,a Ali Jasaa
Keyword(s):  
Callus Induction ◽  
Dry Weight ◽  
Nerium Oleander ◽  
Active Compounds ◽  
Young Leaves ◽  
Dichlorophenoxy Acetic Acid ◽  
Qualitative Determination

Callus induction of Nerium oleander young leaves explants was studied using Murashige & Skooge (MS) Medium supplemented with 2,4-dichlorophenoxy acetic acid( 2,4-D 0.0, 0.5, 1.0, 2.0) mg/l with Benzyle adinine (BA0.0, 0.5 or 1.0, mg/l). comparative study was made for qualitative determination of some active compounds between the initiated callus and leaves of fieled plant (intact plant). Results showed that 2,4-D at 1.0 or 2.0 mg/l with BA at 0.5 or 1.0, mg/l were the best for callus induction that gave the highest fresh and dry weight. Qualitative detection showed that (Alkaloids, Flavonoids, Terpenoids, Tanins, Saponins, and Cardiac Glycosides) the main active compounds were found in callus and leaves of field-grown plant.

Determination of in vitro „anti-aging„-effects of Ganoderma pfeifferi

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
W Jülich ◽  
J Pörksen ◽  
H Welzel ◽  
U Lindequist
Keyword(s):  
Aging Effects

In vitro determination of the skin anti-aging potential of eleven South African plants

Planta Medica ◽  
2013 ◽  
Vol 79 (13) ◽  
Author(s):  
GN Ndlovu ◽  
G Fouche ◽  
W Cordier ◽  
V Steenkamp ◽  
M Tselanyane
Keyword(s):  
South African ◽  
South African Plants ◽  
African Plants
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