Aim:
The study was aimed to develop mucoadhesive buccal tablets using Aster ericoides
leaves mucilage.
Background :
Mucilages are naturally occurring high-molecular-weight polyuronides, which have been
extensively studied for their application in different pharmaceutical dosage forms.
Objective:
The objective of the present research was to establish the mucilage isolated from the leaves
of Aster ericoides as an excipient for the formulation of the mucoadhesive buccal tablet.
Method:
The mucilage was isolated from the leaves of Aster ericoides by maceration, precipitated with
acetone and characterized. Tablets were prepared using wet granulation technique and evaluated for various
official tests.
Results:
The mucilage was found to be non-toxic on A-431 and Vero cell lines. It was insoluble but
swellable in cold and hot water. The results indicate that mucilage can form a three-dimensional network.
The pH of the mucilage (6.82 ± 0.13) indicated that it might be non-irritant to the buccal cavity.
The mucilage was found to be free from microbes. The release of drug was by Fickian diffusion. The in
vivo buccal tablet acceptance was 80%. No significant difference between the diastolic blood pressure of
standard and Aster tablets treated volunteer group was recorded.
Conclusion:
The mucilage was found to be non-toxic on A-431 and Vero cell lines. It was insoluble but
swellable in cold and hot water. The results indicate that mucilage can form a three-dimensional network.
The pH of the mucilage (6.82 ± 0.13) indicated that it might be non-irritant to the buccal cavity.
The mucilage was found to be free from microbes. The release of drug was by Fickian diffusion. The in
vivo buccal tablet acceptance was 80%. No significant difference between the diastolic blood pressure of
standard and Aster tablets treated volunteer group was recorded.
Other:
However, to prove the potency of the polymer, in vivo bioavailability studies in human volunteers
are needed along with chronic toxicity studies in suitable animal models.
<i>In Vivo</i> Evaluation of the Antiplasmodial Property of Ethanol and Hot Water Extracts of <i>Pleurotus ostreatus</i> Mushroom
