Interleukin-8 Production by Cystic Fibrosis Nasal Epithelial Cells after Tumor Necrosis Factor- α and Respiratory Syncytial Virus Stimulation

1998 ◽  
Vol 19 (2) ◽  
pp. 210-215 ◽  
Author(s):  
Hugh R. Black ◽  
James R. Yankaskas ◽  
Larry G. Johnson ◽  
Terry L. Noah
Keyword(s):  
Cystic Fibrosis ◽  
Respiratory Syncytial Virus ◽  
Tumor Necrosis Factor ◽  
Epithelial Cells ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Interleukin 8 ◽  
Syncytial Virus ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Modification of transepithelial ion transport in human cultured bronchial epithelial cells by interferon-γ

2000 ◽  
Vol 278 (6) ◽  
pp. L1186-L1194 ◽  
Author(s):  
Luis J. V. Galietta ◽  
Chiara Folli ◽  
Carla Marchetti ◽  
Luca Romano ◽  
Daniela Carpani ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Tumor Necrosis Factor ◽  
Epithelial Cells ◽  
Ion Transport ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Interferon Γ ◽  
Bronchial Epithelial ◽  
Factor Α ◽  
Necrosis Factor

Human bronchial epithelial cells were treated in vitro with interferon-γ or tumor necrosis factor-α to assess their effect on transepithelial ion transport. Short-circuit current measurements revealed that Na+absorption was markedly inhibited by interferon-γ (10–1,000 U/ml). The cystic fibrosis transmembrane conductance regulator was also downregulated by interferon-γ as evident at the protein level and by the decrease in the cAMP-dependent current. On the other hand, interferon-γ caused an increase of the current elicited by apical UTP application, which is due to the activity of Ca2+-dependent Cl−channels. Tumor necrosis factor-α caused few changes in ion transport. Transepithelial fluid transport was measured in normal and cystic fibrosis cells. At rest, both types of cells showed an amiloride-sensitive fluid absorption that was inhibited by interferon-γ but not by tumor necrosis factor-α. Our results show that interferon-γ alters the transepithelial ion transport of cultured bronchial cells. This effect may change the ion composition and/or volume of periciliary fluid.

Grepafloxacin inhibits tumor necrosis factor- α-induced interleukin-8 expression in human airway epithelial cells

Life Sciences ◽  
1999 ◽  
Vol 66 (5) ◽  
pp. PL77-PL82 ◽  
Author(s):  
Shu Hashimoto ◽  
Ken Matsumoto ◽  
Yasuhiro Gon ◽  
Shuichiro Maruoka ◽  
Shinichi Hayashi ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Epithelial Cells ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Airway Epithelial Cells ◽  
Interleukin 8 ◽  
Airway Epithelial ◽  
Human Airway ◽  
Factor Α ◽  
Necrosis Factor
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