Human Upper Airway Structural Cell-derived Cytokines Support Human Peripheral Blood Monocyte Survival: A Potential Mechanism for Monocyte/Macrophage Accumulation in the Tissue

1992 ◽  
Vol 6 (2) ◽  
pp. 212-218 ◽  
Author(s):  
Zhou Xing ◽  
Takayuki Ohtoshi ◽  
Peter Ralph ◽  
Jack Gauldie ◽  
Manel Jordana
Keyword(s):  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Upper Airway ◽  
Peripheral Blood Monocyte ◽  
Blood Monocyte ◽  
Potential Mechanism ◽  
Structural Cell ◽  
Human Peripheral Blood Monocyte ◽  
Macrophage Accumulation

CC Chemokine Receptors, CCR-1 and CCR-3, Are Potentially Involved in Antigen-Presenting Cell Function of Human Peripheral Blood Monocyte-Derived Dendritic Cells

Blood ◽  
1999 ◽  
Vol 93 (1) ◽  
pp. 34-42 ◽  
Author(s):  
Katsuaki Sato ◽  
Hiroshi Kawasaki ◽  
Hitomi Nagayama ◽  
Ryo Serizawa ◽  
Junji Ikeda ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Peripheral Blood ◽  
Chemokine Receptors ◽  
Human Peripheral Blood ◽  
Flow Cytometric Analysis ◽  
Peripheral Blood Monocyte ◽  
Interleukin 4 ◽  
Blood Monocyte ◽  
Cc Chemokine ◽  
Human Peripheral Blood Monocyte

Abstract We examined the potential involvement of two CC chemokine receptors (CCRs), CCR-1 and CCR-3, in the functional activation of granulocyte-macrophage colony-stimulating factor (GM-CSF) plus interleukin-4 (IL-4)–generated human peripheral blood monocyte-derived immature dendritic cells (DCs). Flow cytometric analysis showed that CCR-1, CCR-3, CCR-5, and CXC chemokine receptor (CXCR)-4 were expressed on the cell surface of monocyte-derived DCs. Treatment with a monoclonal antibody (MoAb) to either CCR-1 or CCR-3 but not MoAbs to CCR-5 and CXCR-4 abolished chemotactic migration of monocyte-derived DCs. The DCs treated with either the anti–CCR-1 MoAb or anti–CCR-3 MoAb were less efficient than untreated DCs in proliferation of allogeneic T cells (TCs) and TC-derived secretion of interferon-γ (IFN-γ). The homotypic aggregation of DCs and heterotypic aggregation of DCs with TCs were suppressed by the anti–CCR-1 MoAb or anti–CCR-3 MoAb. These results indicate that CCR-1 and CCR-3 specifically regulate interaction of TCs and DCs in the process of antigen presentation.

Asbestos-Induced Alteration of Human Peripheral Blood Monocyte Activity

1982 ◽  
Vol 69 (4) ◽  
pp. 302-305 ◽  
Author(s):  
James Doll ◽  
Brian E. Bozelka ◽  
Susan Goldbach ◽  
Eliseo Añorve-López ◽  
John E. Salvaggio
Keyword(s):  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Peripheral Blood Monocyte ◽  
Blood Monocyte ◽  
Human Peripheral Blood Monocyte

The effects of γ-interferon on human peripheral blood monocyte/macrophage-mediated bone particle degradation

1990 ◽  
Vol 8 (2) ◽  
pp. 131-143 ◽  
Author(s):  
Robert Terkeltaub ◽  
Gary S. Firestein ◽  
Richard S. Kornbluth ◽  
Jody Martin ◽  
Deborah Curran ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Peripheral Blood Monocyte ◽  
Blood Monocyte ◽  
Bone Particle ◽  
Human Peripheral Blood Monocyte ◽  
Γ Interferon
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