The Long Noncoding RNA LnRPT Is Regulated by PDGF-BB and Modulates the Proliferation of Pulmonary Artery Smooth Muscle Cells

2018 ◽  
Vol 58 (2) ◽  
pp. 181-193 ◽  
Author(s):  
Jidong Chen ◽  
Jiao Guo ◽  
Xiaolei Cui ◽  
Yan Dai ◽  
Zhixiong Tang ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Pulmonary Artery ◽  
Smooth Muscle Cells ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Muscle Cells ◽  
Pulmonary Artery Smooth Muscle

Long noncoding RNA UCA1 promotes the proliferation of hypoxic human pulmonary artery smooth muscle cells

2018 ◽  
Vol 471 (2) ◽  
pp. 347-355 ◽  
Author(s):  
Tian-Tian Zhu ◽  
Rui-Li Sun ◽  
Ya-Ling Yin ◽  
Jin-Ping Quan ◽  
Ping Song ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Pulmonary Artery ◽  
Smooth Muscle Cells ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Muscle Cells ◽  
Pulmonary Artery Smooth Muscle ◽  
Human Pulmonary Artery

Long noncoding RNA Hoxaas3 contributes to hypoxia-induced pulmonary artery smooth muscle cell proliferation

2018 ◽  
Vol 115 (3) ◽  
pp. 647-657 ◽  
Author(s):  
Hongyue Zhang ◽  
Ying Liu ◽  
Lixin Yan ◽  
Siqi Wang ◽  
Min Zhang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Smooth Muscle ◽  
Pulmonary Artery ◽  
Smooth Muscle Cells ◽  
Noncoding Rna ◽  
Muscle Cells ◽  
Cell Cycle Distribution ◽  
Hoxa Cluster ◽  
Protein Levels ◽  
Pulmonary Artery Smooth Muscle

Abstract Aims Long noncoding RNAs (lncRNAs) are involved in the regulation of vascular smooth muscle cells and cardiovascular pathology. However, the contribution of lncRNAs to pulmonary hypertension (PH) remains largely unknown. The over-proliferation of pulmonary artery smooth muscle cells (PASMCs) causes pulmonary arterial smooth muscle hypertrophy and stenosis of the pulmonary vascular lumen, resulting in PH. Here, we investigated the biological role of a novel lncRNA, Hoxa cluster antisense RNA 3 (Hoxaas3), in the regulation of cell proliferation in PH. Methods and results Hoxaas3 was up-regulated in the lung vasculature of hypoxic mice and in PASMCs under hypoxic conditions. Histone H3 Lysine 9 acetylation of Hoxaas3 promoted gene expression. Moreover, high expression of Hoxaas3 was associated with cell proliferation and modulated cell cycle distribution by up-regulating Homeobox a3 at the mRNA and protein levels. Conclusion This study defined the role and mechanism of action of Hoxaas3 in the regulation of cell proliferation in PH, which should facilitate the development of new therapeutic strategies for the treatment of this disease.

570 Antiproliferative effect of sildenafil on pulmonary artery smooth muscle cells

2003 ◽  
Vol 2 (1) ◽  
pp. 123
Author(s):  
B TANTINI ◽  
M FATTORI ◽  
E FIUMANA ◽  
A MANES ◽  
N GALIE ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Pulmonary Artery ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Antiproliferative Effect ◽  
Pulmonary Artery Smooth Muscle

Hypoxic Growth of Bovine Pulmonary Artery Smooth Muscle Cells

CHEST Journal ◽  
1998 ◽  
Vol 114 (1) ◽  
pp. 29S-30S ◽  
Author(s):  
Edward C. Dempsey ◽  
Mita Das ◽  
Maria G. Frid ◽  
Yongjian Xu ◽  
Kurt R. Stenmark
Keyword(s):  
Smooth Muscle ◽  
Pulmonary Artery ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Pulmonary Artery Smooth Muscle

Role of Rho in the Increased Migration of Pulmonary Artery Smooth Muscle Cells Observed in the Neprilysin Knockout Mouse

CHEST Journal ◽  
2005 ◽  
Vol 128 (6) ◽  
pp. 582S-583S
Author(s):  
Vijaya Karoor ◽  
Sandra J. Walchak ◽  
York E. Miller ◽  
Edward C. Dempsey
Keyword(s):  
Smooth Muscle ◽  
Pulmonary Artery ◽  
Smooth Muscle Cells ◽  
Knockout Mouse ◽  
Muscle Cells ◽  
Pulmonary Artery Smooth Muscle

Upregulation of profilin, cofilin-2 and LIMK2 in cultured pulmonary artery smooth muscle cells and in pulmonary arteries of monocrotaline-treated rats

2006 ◽  
Vol 44 (5) ◽  
pp. 275-282 ◽  
Author(s):  
Yan-Ping Dai ◽  
Shaner Bongalon ◽  
Honglin Tian ◽  
Samuel D. Parks ◽  
Violeta N. Mutafova-Yambolieva ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Pulmonary Artery ◽  
Smooth Muscle Cells ◽  
Pulmonary Arteries ◽  
Muscle Cells ◽  
Pulmonary Artery Smooth Muscle
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