Anti-Angiogenic Effects of Some (5-hydroxy-4-methyl-2-((1-methyl-1H-indol-3-yl)methyl)-Thieno[2,3-d] Pyrimidine Derivatives

2017 ◽  
Vol 14 (1) ◽  
pp. 448-453 ◽  
Author(s):  
Abd El-Galil E Amr ◽  
Mohamed M Abdalla ◽  
Nabil H Ouf
Keyword(s):  
Brain Tumors ◽  
Sphingosine Kinase ◽  
Pyridine Derivatives ◽  
Ascites Tumor ◽  
Pyrimidine Derivatives ◽  
Tumor Inhibition ◽  
Ehrlich Ascites ◽  
Eat Cells ◽  
Potent Tumor

Some previously reported pyrimidine candidates 1–7 were founded to have potent tumor inhibition activities on diffrrent models of human primary and secondary brain tumors and in the same time these derivatives were founded to have potent anti-angiogenic effects on Ehrlich Ascites Tumor [EAT] cells in-vivo. These pyridine derivatives were founded to be selectively inhibit the p110α isoform. These pyridine derivatives were potent inhibited the histone deactylase. Also, they are inhibited the Sphingosine kinase SK1 activities.

scholarly journals Synthesis, Characterization and Anti-Angiogenic Effects of Novel 5-Amino Pyrazole Derivatives on Ehrlich Ascites Tumor [EAT] Cells in-Vivo

2010 ◽  
Vol 01 (01) ◽  
pp. 1-9 ◽  
Author(s):  
H. Raju ◽  
S. Chandrappa ◽  
M. K. Ramakrishna ◽  
T. S. Nagamani ◽  
H. Ananda ◽  
...  
Keyword(s):  
Ehrlich Ascites Tumor ◽  
Pyrazole Derivatives ◽  
Ascites Tumor ◽  
Ehrlich Ascites ◽  
Eat Cells

scholarly journals The Anti-Tumoral Effects of Wolfberry (Lycium barbarum) on Experimentally Induced Ehrlich Ascites Carcinoma in Mice

Proceedings ◽  
2019 ◽  
Vol 40 (1) ◽  
pp. 38
Author(s):  
Uçar ◽  
Ülger ◽  
AL ◽  
Nisari ◽  
Karatoprak
Keyword(s):  
Histopathological Examination ◽  
Apoptotic Cell ◽  
Ehrlich Ascites Carcinoma ◽  
Lycium Barbarum ◽  
In Vitro Techniques ◽  
Cell Percentage ◽  
Ehrlich Ascites ◽  
Eat Cells

Wolfberry (Lycium barbarum) shows strengthen immune system, antioxidant and anticancerogenic effect. In this research, the effects of Wolfberry's extract fractions, cultivated in Kayseri, investigated on Ehrlich ascites tumor (EAT) using in vivo and in vitro techniques. For in vivo study, 200 mg/kg fractions of Wolfberry extract (above and below 50 kDa) were injected ip to EAT injected Balb/C mice. EAT cells were also cultured in the presence of Wolfberry's extract fractions (1500, 2000 µg/ml) to examine cell vitality and apoptosis using the Muse Cell Analyzer. Histopathological examination of intra-abdominal organs showed that there were decrease in the EAT cells adherence in the Wolfberry applied tissue groups when compared to the control. According to in vitro results, the both extract fractions (above and below 50 kDa) increased apoptosis in cancer cells. However, total apoptotic cell percentage was higher and statistically significant in groups above 50 kDa (1500, 2000 mg/ml) (p < 0.05). Previous literature and the results of the present study reveal that the consumption of wolfberry—which is also produced in Turkey—might be effective in preventing the formation of cancer and the deceleration of its progress.

Sign in / Sign up

Export Citation Format

Share Document