A Generalized Transfer Function Method for Reconstruction of Continuous Brachial Artery Pressure Based on Digital Measurement

2019 ◽  
Vol 9 (8) ◽  
pp. 1583-1589
Author(s):  
Pandeng Zhang ◽  
Ye Chen ◽  
Haibo Chen ◽  
Jia Liu
Keyword(s):  
Blood Pressure ◽  
Transfer Function ◽  
Brachial Artery ◽  
Delay Time ◽  
Cross Validation ◽  
Digital Measurement ◽  
Digital Artery ◽  
Artery Pressure ◽  
Tenfold Cross Validation ◽  
Generalized Transfer Function

Objective: To reconstruct brachial artery pressure (BAP) distally from digital artery pressure (DAP). Methods: We hypothesize that continuous BAP can simply be approximated by sum of two halves of the continuous DAP shifted by the delay time. In order to test it, we enrolled 30 healthy volunteers for two experiments. We firstly showed that the pressure wave in the digital artery can be considered twice as much as the forward/backward wave in the finger. A simplified individualized transfer function was then derived so as to estimate BAP from DAP with the parameter of delay time estimated by tenfold cross validation. Finally, by comparing with a reference BAP, we found that the proposed method can correct the DAP. Result: The errors of the proposed method in estimating systolic and diastolic pressures are 0.4 ± 6.2 and 0.7 ± 3.7 mmHg, respectively. These results agree with the standard of Association for the Advancement of Medical Instrumentation (AAMI). Discussion: In our method, large arteries are modeled with a uniform, frictionless tube, while small arteries are represented as a terminal load. The unknown parameter of the delay time are estimated by tenfold cross validation. Conclusion: Our method is therefore promising in estimating continuous proximal blood pressure from peripheral blood pressure in practice.

Individualized Transfer Functions for the Noninvasive Estimation of Central Pressure From Brachial Pressure Readings

2009 ◽  
Author(s):  
Ashis Mookerjee ◽  
Ahmed M. Al-Jumaily ◽  
Andrew Lowe
Keyword(s):  
Blood Pressure ◽  
Transfer Function ◽  
Brachial Artery ◽  
Transfer Functions ◽  
Patient Characteristics ◽  
Patient Specific ◽  
Model Parameters ◽  
Brachial Blood Pressure ◽  
Noninvasive Estimation ◽  
Artery Segment

A model-based investigation is carried out with the aim of developing an ab-initio methodology for the patient-specific estimation of central pressures from brachial blood pressure readings. The subclavian root-brachial artery segment is modeled as a 1-D tube with all model parameters linked to patient characteristics. A simulation is also run with typical physiological parameters, which gives a “first estimate” of the transfer function (TF). The TF derived using the patient characteristics is studied in detail to investigate the change in the arterial TF occurring with changes in patient characteristics. This TF is compared with the “first estimate” to evaluate the feasibility of using standard arterial properties.

scholarly journals Validation of a Generalized Transfer Function to Noninvasively Derive Central Blood Pressure During Exercise

Hypertension ◽  
2006 ◽  
Vol 47 (6) ◽  
pp. 1203-1208 ◽  
Author(s):  
James E. Sharman ◽  
Richard Lim ◽  
Ahmad M. Qasem ◽  
Jeff S. Coombes ◽  
Malcolm I. Burgess ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Transfer Function ◽  
Central Blood Pressure ◽  
Generalized Transfer Function

scholarly journals Significance of Pulsatility of Brachial Artery Pressure for Blood Pressure Control

2008 ◽  
Vol 49 (3) ◽  
pp. 295-302
Author(s):  
Yuji Yoshitomi ◽  
Toshikazu Ishii ◽  
Takashi Tsujibayashi ◽  
Masashi Kaneki ◽  
Shun-ichiro Sakurai
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Control ◽  
Brachial Artery ◽  
Pressure Control ◽  
Artery Pressure

Use of generalized transfer function-derived central blood pressure for the calculation of baroreflex gain

2008 ◽  
Vol 26 (6) ◽  
pp. 1156-1162 ◽  
Author(s):  
Péter Studinger ◽  
Imre Ungi ◽  
Zsuzsanna Lénárd ◽  
Beatrix Mersich ◽  
László Rudas ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Transfer Function ◽  
Central Blood Pressure ◽  
Generalized Transfer Function

A Comparison of the Acute Haemodynamic Effects of Propranolol and Pindolol at Rest and during Supine Exercise in Man

1980 ◽  
Vol 59 (s6) ◽  
pp. 465s-468s ◽  
Author(s):  
T. L. Svendsen ◽  
J. E. Carlsen ◽  
O. Hartling ◽  
A. McNair ◽  
J. Trap-Jensen
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Cardiac Output ◽  
Pulmonary Artery ◽  
Pulmonary Artery Pressure ◽  
Response Curves ◽  
Receptor Blocking ◽  
Artery Pressure ◽  
Arterial Blood ◽  
Β Receptor

1. Dose-response curves for heart rate, cardiac output, arterial blood pressure and pulmonary artery pressure were obtained in 16 male patients after intravenous administration of three increasing doses of pindolol, propranolol or placebo. All patients had an uncomplicated acute myocardial infarction 6–8 months earlier. 2. The dose-response curves were obtained at rest and during repeated bouts of supine bicycle exercise. The cumulative dose amounted to 0.024 mg/kg body weight for pindolol and to 0.192 mg/kg body weight for propranolol. 3. At rest propranolol significantly reduced heart rate and cardiac output by 12% and 15% respectively. Arterial mean blood pressure was reduced by 9.2 mmHg. Mean pulmonary artery pressure increased significantly by 2 mmHg. Statistically significant changes in these variables were not seen after pindolol or placebo. 4. During exercise pindolol and propranolol both reduced cardiac output, heart rate and arterial blood pressure to the same extent. After propranolol mean pulmonary artery pressure was increased significantly by 3.6 mmHg. Pindolol and placebo did not change pulmonary artery pressure significantly. 5. The study suggests that pindolol may offer haemodynamic advantages over β-receptor-blocking agents without intrinsic sympathomimetic activity during low activity of the sympathetic nervous system, and may be preferable in situations where the β-receptor-blocking effect is required only during physical or psychic stress.

Abstract 062: Aortic Stiffness, Blood Pressure Progression and Incident Hypertension: The Framingham Heart Study

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Bernhard M Kaess ◽  
Jian Rong ◽  
Martin G Larson ◽  
Naomi M Hamburg ◽  
Joseph A Vita ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Brachial Artery ◽  
Aortic Stiffness ◽  
Wave Amplitude ◽  
Augmentation Index ◽  
Vascular Stiffness ◽  
Flow Mediated Dilation ◽  
Forward Wave ◽  
Incident Hypertension

Background: Increased vascular stiffness and excessive blood pressure (BP) pulsatility are important risk factors for age-related morbidity. Vascular stiffness and BP pulsatility are related, with a prevailing view that hypertension antedates and contributes to premature vascular aging and a secondary increase in vascular stiffness. However, temporal relations between comprehensive vascular measures and BP elevation have not been fully delineated in a large community-based sample. Methods: We examined longitudinal relations of BP and 3 measures of vascular stiffness and pressure pulsatility derived from arterial tonometry (carotid-femoral pulse wave velocity [CFPWV], forward wave amplitude and augmentation index) over a 7-year period in 1,898 Framingham Offspring participants (mean age 60 yrs, 1,057 women). We also examined relations between measures of microvascular and endothelial function derived from brachial artery Doppler and future progression of BP or vascular stiffness. Results: In multivariable-adjusted regression models, baseline tonometry measures were separately and jointly associated with higher systolic and pulse pressure and incident hypertension ( Table ). Conversely, higher baseline BP was associated with higher forward wave amplitude and augmentation index (all p<0.05) but not CFPWV at follow-up. Higher baseline resting brachial artery flow and lower flow-mediated dilation were associated with incident hypertension in models that included BP and tonometry measures ( Table ). Conclusion: Higher aortic stiffness (CFPWV), pressure pulsatility (forward wave amplitude), and wave reflection (augmentation index) and lower flow-mediated dilation are associated with blood pressure progression and incident hypertension. Our findings support the notion of aortic stiffness as a precursor of hypertension and further suggest a vicious cycle of increasing pressure pulsatility with advancing age. Table. Correlates of incident hypertension. Predictor Variables (baseline) OR 95% CI P Systolic BP 3.24 (2.17; 4.84) <0.0001 Diastolic BP 1.47 (1.13; 1.92) 0.0042 CFPWV 1.30 (1.02; 1.67) 0.037 Forward wave amplitude 1.66 (1.32; 2.09) <0.0001 Augmentation index 1.78 (1.45; 2.17) <0.0001 Brachial artery baseline flow 1.23 (1.05; 1.45) 0.013 Flow-mediated dilation 0.83 (0.70; 0.98) 0.029 Results of a single multivariable model that further adjusted for age,sex, BMI, height and triglycerides in 1,019 participants free of hypertension at baseline who experienced 337 cases of incident hypertension during follow-up. OR expressed per 1 SD of the independent variable.

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