Shifts in interocular balance resulting from short-term monocular deprivation in adult macaque visual cortex are not magno-dominated

AbstractVisual cortex, particularly V1, is considered to be resilient to plastic changes in adults. In particular, ocular dominance is assumed to be hard-wired after the end of the critical period. We show that short-term (2h) monocular deprivation in adult humans boosts the BOLD response to the deprived eye, changing ocular dominance of V1 vertices, consistently with homeostatic plasticity. The boost is strongest in V1, present in V2, V3 & V4 but absent in V3a and MT. Assessment of spatial frequency tuning in V1 by a population Receptive-Field technique shows that deprivation primarily boosts high spatial frequencies, consistent with a primary involvement of the parvocellular pathway. Crucially, the V1 deprivation effect correlates across participants with the perceptual increase of the deprived eye dominance assessed with binocular rivalry, suggesting a common origin. Our results demonstrate that visual cortex, particularly the ventral pathway, retains a high potential for homeostatic plasticity in the human adult.

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Short-Term Monocular Deprivation Alters GABA in the Adult Human Visual Cortex

Current Biology ◽

10.1016/j.cub.2015.04.021 ◽

2015 ◽

Vol 25 (11) ◽

pp. 1496-1501 ◽

Cited By ~ 84

Author(s):

Claudia Lunghi ◽

Uzay E. Emir ◽

Maria Concetta Morrone ◽

Holly Bridge

Keyword(s):

Visual Cortex ◽

Monocular Deprivation ◽

Short Term ◽

Human Visual Cortex ◽

Adult Human

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The effects of short-term occlusion therapy on reversal of the anatomical and physiological effects of monocular deprivation in the lateral geniculate nucleus and visual cortex of kittens

Experimental Brain Research ◽

10.1007/bf00237196 ◽

1983 ◽

Vol 51 (2) ◽

Cited By ~ 9

Author(s):

S.G. Crewther ◽

D.P. Crewther ◽

D.E. Mitchell

Keyword(s):

Visual Cortex ◽

Lateral Geniculate Nucleus ◽

Monocular Deprivation ◽

Physiological Effects ◽

Short Term ◽

Occlusion Therapy ◽

Lateral Geniculate

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Response to short-term deprivation of the human adult visual cortex measured with 7T BOLD

eLife ◽

10.7554/elife.40014 ◽

2018 ◽

Vol 7 ◽

Cited By ~ 20

Author(s):

Paola Binda ◽

Jan W Kurzawski ◽

Claudia Lunghi ◽

Laura Biagi ◽

Michela Tosetti ◽

...

Keyword(s):

Visual Cortex ◽

Frequency Tuning ◽

Sensory Deprivation ◽

Ocular Dominance ◽

Monocular Deprivation ◽

Homeostatic Plasticity ◽

Short Term ◽

Structural Reorganization ◽

Parvocellular Pathway ◽

Human Adult

Sensory deprivation during the post-natal ‘critical period’ leads to structural reorganization of the developing visual cortex. In adulthood, the visual cortex retains some flexibility and adapts to sensory deprivation. Here we show that short-term (2 hr) monocular deprivation in adult humans boosts the BOLD response to the deprived eye, changing ocular dominance of V1 vertices, consistent with homeostatic plasticity. The boost is strongest in V1, present in V2, V3 and V4 but absent in V3a and hMT+. Assessment of spatial frequency tuning in V1 by a population Receptive-Field technique shows that deprivation primarily boosts high spatial frequencies, consistent with a primary involvement of the parvocellular pathway. Crucially, the V1 deprivation effect correlates across participants with the perceptual increase of the deprived eye dominance assessed with binocular rivalry, suggesting a common origin. Our results demonstrate that visual cortex, particularly the ventral pathway, retains a high potential for homeostatic plasticity in the human adult.

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Short-term plasticity in the visual thalamus

10.1101/2021.10.14.464354 ◽

2021 ◽

Author(s):

Jan W Kurzawski ◽

Claudia Lunghi ◽

Laura Biagi ◽

Michela Tosetti ◽

Maria Concetta Morrone ◽

...

Keyword(s):

Visual Cortex ◽

Visual Processing ◽

Ocular Dominance ◽

Monocular Deprivation ◽

Spatial Proximity ◽

Short Term ◽

Ocular Dominance Plasticity ◽

Short Term Plasticity ◽

Visual Thalamus ◽

Plasticity Effect

While there is evidence that the visual cortex retains a potential for plasticity in adulthood, less is known about the subcortical stages of visual processing. Here we asked whether short-term ocular dominance plasticity affects the visual thalamus. We addressed this question in normally sighted adult humans, using ultra-high field (7T) magnetic resonance imaging combined with the paradigm of short-term monocular deprivation. With this approach, we previously demonstrated transient shifts of perceptual eye dominance and ocular dominance in visual cortex (Binda et al., 2018). Here we report evidence for short-term plasticity in the ventral division of the pulvinar (vPulv), where the deprived eye representation was enhanced over the non-deprived eye. This pulvinar plasticity effect was similar as previously seen in visual cortex and it was correlated with the ocular dominance shift measured behaviorally. In contrast, there was no short-term plasticity effect in Lateral Geniculate Nucleus (LGN), where results were reliably different from vPulv, despite their spatial proximity. We conclude that the visual thalamus retains potential for short-term plasticity in adulthood; the plasticity effect differs across thalamic subregions, possibly reflecting differences in their cortical connectivity.

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Long- and short-term monocular deprivation in the rhesus monkey: effects on visual fields and optokinetic nystagmus

Journal of Neuroscience ◽

10.1523/jneurosci.06-06-01771.1986 ◽

1986 ◽

Vol 6 (6) ◽

pp. 1771-1780 ◽

Cited By ~ 25

Author(s):

DL Sparks ◽

LE Mays ◽

MR Gurski ◽

TL Hickey

Keyword(s):

Rhesus Monkey ◽

Optokinetic Nystagmus ◽

Visual Fields ◽

Monocular Deprivation ◽

Short Term

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Elastic Net Model of Ocular Dominance: Overall Stripe Pattern and Monocular Deprivation

Neural Computation ◽

10.1162/neco.1994.6.4.615 ◽

1994 ◽

Vol 6 (4) ◽

pp. 615-621 ◽

Cited By ~ 29

Author(s):

Geoffrey J. Goodhill ◽

David J. Willshaw

Keyword(s):

Visual Cortex ◽

Lateral Geniculate Nucleus ◽

Primary Visual Cortex ◽

Ocular Dominance ◽

Monocular Deprivation ◽

Elastic Net ◽

Global Order ◽

Stripe Pattern ◽

Lateral Geniculate ◽

Stripe Width

The elastic net (Durbin and Willshaw 1987) can account for the development of both topography and ocular dominance in the mapping from the lateral geniculate nucleus to primary visual cortex (Goodhill and Willshaw 1990). Here it is further shown for this model that (1) the overall pattern of stripes produced is strongly influenced by the shape of the cortex: in particular, stripes with a global order similar to that seen biologically can be produced under appropriate conditions, and (2) the observed changes in stripe width associated with monocular deprivation are reproduced in the model.

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Gender-specific modulation of short-term neuroplasticity in the visual cortex induced by transcranial direct current stimulation

Visual Neuroscience ◽

10.1017/s0952523808080097 ◽

2008 ◽

Vol 25 (1) ◽

pp. 77-81 ◽

Cited By ~ 77

Author(s):

LEILA CHAIEB ◽

ANDREA ANTAL ◽

WALTER PAULUS

Keyword(s):

Sex Differences ◽

Visual Cortex ◽

Direct Current ◽

Transcranial Direct Current Stimulation ◽

Cortical Excitability ◽

Gonadal Hormones ◽

Study Data ◽

Short Term ◽

Direct Current Stimulation ◽

Significant Difference

Transcranial direct current stimulation (tDCS) is a non-invasive method of modulating levels of cortical excitability. In this study, data gathered over a number of previously conducted experiments before and after tDCS, has been re-analyzed to investigate correlations between sex differences with respect to neuroplastic effects. Visual evoked potentials (VEPs), phosphene thresholds (PTs), and contrast sensitivity measurements (CSs) are used as indicators of the excitability of the primary visual cortex. The data revealed that cathodally induced excitability effects 10 min post stimulation with tDCS, showed no significant difference between genders. However, stimulation in the anodal direction revealed sex-specific effects: in women, anodal stimulation heightened cortical excitability significantly when compared to the age-matched male subject group. There was no significant difference between male and female subjects immediately after stimulation. These results indicate that sex differences exist within the visual cortex of humans, and may be subject to the influences of modulatory neurotransmitters or gonadal hormones which mirror short-term neuroplastic effects.

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Critical period for monocular deprivation in the cat visual cortex

Journal of Neurophysiology ◽

10.1152/jn.1992.67.1.197 ◽

1992 ◽

Vol 67 (1) ◽

pp. 197-202 ◽

Cited By ~ 157

Author(s):

N. W. Daw ◽

K. Fox ◽

H. Sato ◽

D. Czepita

Keyword(s):

Visual Cortex ◽

Critical Period ◽

Single Cells ◽

Ocular Dominance ◽

Monocular Deprivation ◽

Significant Shift ◽

Cat Visual Cortex

1. Cats were monocularly deprived for 3 mo starting at 8-9 mo, 12 mo, 15 mo, and several years of age. Single cells were recorded in both visual cortexes of each cat, and the ocular dominance and layer determined for each cell. Ocular dominance histograms were then constructed for layers II/III, IV, and V/VI for each group of animals. 2. There was a statistically significant shift in the ocular dominance for cells in layers II/III and V/VI for the animals deprived between 8-9 and 11-12 mo of age. There was a small but not statistically significant shift for cells in layer IV from the animals deprived between 8-9 and 11-12 mo of age, and for cells in layers V/VI from the animals deprived between 15 and 18 mo of age. There was no noticeable shift in ocular dominance for any other layers in any other group of animals. 3. We conclude that the critical period for monocular deprivation is finally over at approximately 1 yr of age for extragranular layers (layers II, III, V, and VI) in visual cortex of the cat.

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