Ocular Pharmacokinetics of Intravitreally Administered Brimonidine and Dexamethasone in Animal Models With and Without Blood–Retinal Barrier Breakdown

2014 ◽  
Vol 55 (2) ◽  
pp. 1056 ◽  
Author(s):  
Jie Shen ◽  
Chandra Durairaj ◽  
Ton Lin ◽  
Yan Liu ◽  
James Burke
Keyword(s):  
Animal Models ◽  
Ocular Pharmacokinetics ◽  
Blood Retinal Barrier ◽  
Barrier Breakdown

Role of inflammation in blood-retinal barrier breakdown: animal models

2008 ◽  
Vol 86 ◽  
pp. 0-0
Author(s):  
AF AMBROSIO ◽  
EC LEAL ◽  
A MANIVANNAN ◽  
J CUNHA-VAZ ◽  
JV FORRESTER
Keyword(s):  
Animal Models ◽  
Blood Retinal Barrier ◽  
Barrier Breakdown

Experimental models of growth factor-mediated angiogenesis and blood–retinal barrier breakdown

2000 ◽  
Vol 35 (5) ◽  
pp. 233-239 ◽  
Author(s):  
Stanley A. Vinores ◽  
M.S. Seo ◽  
N. Okamoto ◽  
J.D. Ash ◽  
E.F. Wawrousek ◽  
...  
Keyword(s):  
Growth Factor ◽  
Experimental Models ◽  
Blood Retinal Barrier ◽  
Barrier Breakdown

scholarly journals Caveolin-1 Increases Proinflammatory Chemoattractants and Blood–Retinal Barrier Breakdown but Decreases Leukocyte Recruitment in Inflammation

2014 ◽  
Vol 55 (10) ◽  
pp. 6224 ◽  
Author(s):  
Xiaoman Li ◽  
Xiaowu Gu ◽  
Timothy M. Boyce ◽  
Min Zheng ◽  
Alaina M. Reagan ◽  
...  
Keyword(s):  
Leukocyte Recruitment ◽  
Blood Retinal Barrier ◽  
Caveolin 1 ◽  
Barrier Breakdown

scholarly journals TNFSF15 Inhibits Blood Retinal Barrier Breakdown Induced by Diabetes

2016 ◽  
Vol 17 (5) ◽  
pp. 615 ◽  
Author(s):  
Feng Jiang ◽  
Qingzhong Chen ◽  
Liming Huang ◽  
Ying Wang ◽  
Zhuhong Zhang ◽  
...  
Keyword(s):  
Blood Retinal Barrier ◽  
Barrier Breakdown

Characterization of Azurocidin as a Permeability Factor in the Retina: Involvement in VEGF-Induced and Early Diabetic Blood-Retinal Barrier Breakdown

2008 ◽  
Vol 49 (2) ◽  
pp. 726 ◽  
Author(s):  
Dimitra Skondra ◽  
Kousuke Noda ◽  
Lama Almulki ◽  
Faryan Tayyari ◽  
Sonja Frimmel ◽  
...  
Keyword(s):  
Blood Retinal Barrier ◽  
Permeability Factor ◽  
Barrier Breakdown

scholarly journals Topical Drug Delivery to the Posterior Segment of the Eye

Pharmaceutics ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 134
Author(s):  
Marina Löscher ◽  
Chiara Seiz ◽  
José Hurst ◽  
Sven Schnichels
Keyword(s):  
Drug Delivery ◽  
Animal Models ◽  
Treatment Option ◽  
Topical Treatment ◽  
Delivery Systems ◽  
Ocular Drug Delivery ◽  
Posterior Segment ◽  
Retinal Diseases ◽  
Topical Drug Delivery ◽  
Ocular Pharmacokinetics

Topical drug delivery to the posterior segment of the eye is a very complex challenge. However, topical delivery is highly desired, to achieve an easy-to-use treatment option for retinal diseases. In this review, we focus on the drug characteristics that are relevant to succeed in this challenge. An overview on the ocular barriers that need to be overcome and some relevant animal models to study ocular pharmacokinetics are given. Furthermore, a summary of substances that were able to reach the posterior segment after eye drop application is provided, as well as an outline of investigated delivery systems to improve ocular drug delivery. Some promising results of substances delivered to the retina suggest that topical treatment of retinal diseases might be possible in the future, which warrants further research.

scholarly journals Synergistic interactions of PlGF and VEGF contribute to blood-retinal barrier breakdown through canonical NFκB activation

2020 ◽  
Vol 397 (2) ◽  
pp. 112347
Author(s):  
Anton Lennikov ◽  
Anthony Mukwaya ◽  
Lijuan Fan ◽  
Madhu Sudhana Saddala ◽  
Sandro De Falco ◽  
...  
Keyword(s):  
Blood Retinal Barrier ◽  
Synergistic Interactions ◽  
Barrier Breakdown
Sign in / Sign up

Export Citation Format

Share Document