scholarly journals Choroidal Thickness Influences Near-Infrared Reflectance Intensity in Eyes With Geographic Atrophy Due To Age-Related Macular Degeneration

2016 ◽  
Vol 57 (14) ◽  
pp. 6440 ◽  
Author(s):  
Rosa Dolz-Marco ◽  
Orly Gal-Or ◽  
K. Bailey Freund
Keyword(s):  
Macular Degeneration ◽  
Choroidal Thickness ◽  
Near Infrared ◽  
Geographic Atrophy ◽  
Age Related Macular Degeneration ◽  
Infrared Reflectance ◽  
Near Infrared Reflectance ◽  
Age Related

scholarly journals Near-infrared reflectance imaging of neovascular age-related macular degeneration

2009 ◽  
Vol 247 (12) ◽  
pp. 1625-1633 ◽  
Author(s):  
Thomas Theelen ◽  
Tos T. J. M. Berendschot ◽  
Carel B. Hoyng ◽  
Camiel J. F. Boon ◽  
B. Jeroen Klevering
Keyword(s):  
Macular Degeneration ◽  
Near Infrared ◽  
Age Related Macular Degeneration ◽  
Infrared Reflectance ◽  
Near Infrared Reflectance ◽  
Age Related

Choroidal Thickness in Eyes With Central Geographic Atrophy Secondary to Stargardt Disease and Age-Related Macular Degeneration

2015 ◽  
Vol 46 (8) ◽  
pp. 814-822 ◽  
Author(s):  
Renata Portella Nunes ◽  
Potyra R. Rosa ◽  
Andrea Giani ◽  
Raquel Goldhardt ◽  
Benjamin Thomas ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Choroidal Thickness ◽  
Geographic Atrophy ◽  
Age Related Macular Degeneration ◽  
Stargardt Disease ◽  
Age Related

Association Between Subfoveal Choroidal Thickness, Reticular Pseudodrusen, and Geographic Atrophy in Age-Related Macular Degeneration

2015 ◽  
Vol 46 (5) ◽  
pp. 513-521 ◽  
Author(s):  
Mariana R. Thorell ◽  
Raquel Goldhardt ◽  
Renata Portella Nunes ◽  
Carlos Alexandre de Amorim Garcia Filho ◽  
Ashkan M. Abbey ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Choroidal Thickness ◽  
Geographic Atrophy ◽  
Age Related Macular Degeneration ◽  
Subfoveal Choroidal Thickness ◽  
Reticular Pseudodrusen ◽  
Age Related

Choroidal Thickness in Geographic Atrophy Secondary to Age-Related Macular Degeneration

2015 ◽  
Vol 56 (2) ◽  
pp. 875-882 ◽  
Author(s):  
M. Lindner ◽  
A. Bezatis ◽  
J. Czauderna ◽  
E. Becker ◽  
C. K. Brinkmann ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Choroidal Thickness ◽  
Geographic Atrophy ◽  
Age Related Macular Degeneration ◽  
Age Related

scholarly journals A Review of Completed and Ongoing Complement Inhibitor Trials for Geographic Atrophy Secondary to Age-Related Macular Degeneration

2021 ◽  
Vol 10 (12) ◽  
pp. 2580
Author(s):  
Omar A. Halawa ◽  
Jonathan B. Lin ◽  
Joan W. Miller ◽  
Demetrios G. Vavvas
Keyword(s):  
Macular Degeneration ◽  
Geographic Atrophy ◽  
Age Related Macular Degeneration ◽  
Western World ◽  
Complement Factor ◽  
Complement Protein ◽  
Pivotal Phase ◽  
Complement Inhibition ◽  
Exudative Amd ◽  
Age Related

Age-related macular degeneration (AMD) is a leading cause of irreversible blindness among older adults in the Western world. While therapies exist for patients with exudative AMD, there are currently no approved therapies for non-exudative AMD and its advanced form of geographic atrophy (GA). The discovery of genetic variants in complement protein loci with increased susceptibility to AMD has led to the investigation of the role of complement inhibition in AMD with a focus on GA. Here, we review completed and ongoing clinical trials evaluating the safety and efficacy of these studies. Overall, complement inhibition in GA has yielded mixed results. The inhibition of complement factor D has failed pivotal phase 3 trials. Studies of C3 and C5 inhibition meeting their primary endpoint are limited by high rates of discontinuation and withdrawal in the treatment arm and higher risks of conversion to exudative AMD. Studies evaluating other complement members (CFB, CFH, CFI and inhibitors of membrane attack complex—CD59) are ongoing and could offer other viable strategies.

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