Near-Infrared Reflectance Imaging for Quantification of Atrophy Associated with Age-Related Macular Degeneration

2020 ◽  
Vol 212 ◽  
pp. 169-174 ◽  
Author(s):  
Nizar Saleh Abdelfattah ◽  
Jaya Sadda ◽  
Ziyuan Wang ◽  
Zhihong Hu ◽  
Srinivas Sadda
Keyword(s):  
Macular Degeneration ◽  
Near Infrared ◽  
Age Related Macular Degeneration ◽  
Infrared Reflectance ◽  
Near Infrared Reflectance ◽  
Age Related

scholarly journals Near-infrared reflectance imaging of neovascular age-related macular degeneration

2009 ◽  
Vol 247 (12) ◽  
pp. 1625-1633 ◽  
Author(s):  
Thomas Theelen ◽  
Tos T. J. M. Berendschot ◽  
Carel B. Hoyng ◽  
Camiel J. F. Boon ◽  
B. Jeroen Klevering
Keyword(s):  
Macular Degeneration ◽  
Near Infrared ◽  
Age Related Macular Degeneration ◽  
Infrared Reflectance ◽  
Near Infrared Reflectance ◽  
Age Related

scholarly journals Fructosamine-3-Kinase as a Potential Treatment Option for Age-Related Macular Degeneration

2020 ◽  
Vol 9 (9) ◽  
pp. 2869
Author(s):  
Sander De Bruyne ◽  
Caroline Van den Broecke ◽  
Henk Vrielinck ◽  
Samira Khelifi ◽  
Olivier De Wever ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Near Infrared ◽  
Ex Vivo ◽  
Pairwise Comparison ◽  
Age Related Macular Degeneration ◽  
Tissue Sections ◽  
Age Related ◽  
Human Eyes ◽  
Developed World ◽  
First Time

Age-related macular degeneration is the leading cause of blindness in the developed world. Since advanced glycation end products (AGEs) are implicated in the pathogenesis of AMD through various lines of evidence, we investigated the potential of fructosamine-3-kinase (FN3K) in the disruption of retinal AGEs, drusenoid material and drusenoid lesions in patients with AMD. AGE-type autofluorescence was measured to evaluate the effects of FN3K on glycolaldehyde-induced AGE-modified neural porcine retinas and unmodified human neural retinas. Eye pairs from cigarette-smoke- and air-exposed mice were treated and evaluated histologically. Automated optical image analysis of human tissue sections was performed to compare control- and FN3K-treated drusen and near-infrared (NIR) microspectroscopy was performed to examine biochemical differences. Optical coherence tomography (OCT) was used to evaluate the effect of FN3K on drusenoid deposits after treatment of post-mortem human eyes. FN3K treatment provoked a significant decrease (41%) of AGE-related autofluorescence in the AGE-modified porcine retinas. Furthermore, treatment of human neural retinas resulted in significant decreases of autofluorescence (−24%). FN3K-treated murine eyes showed less drusenoid material. Pairwise comparison of drusen on tissue sections revealed significant changes in color intensity after FN3K treatment. NIR microspectroscopy uncovered clear spectral differences in drusenoid material (Bruch’s membrane) and drusen after FN3K treatment. Ex vivo treatment strongly reduced size of subretinal drusenoid lesions on OCT imaging (up to 83%). In conclusion, our study demonstrated for the first time a potential role of FN3K in the disruption of AGE-related retinal autofluorescence, drusenoid material and drusenoid lesions in patients with AMD.

scholarly journals Infrared reflectance imaging in age‐related macular degeneration

2016 ◽  
Vol 36 (3) ◽  
pp. 303-316 ◽  
Author(s):  
Angelica Ly ◽  
Lisa Nivison‐Smith ◽  
Nagi Assaad ◽  
Michael Kalloniatis
Keyword(s):  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Infrared Reflectance ◽  
Age Related

scholarly journals Inner Retinal Layer Thickness Alterations in Early Age Related Macular Degeneration in Eyes with Subretinal Drusenoid Deposits or Conventional Drusen

2021 ◽  
Vol 10 (21) ◽  
pp. 5136
Author(s):  
Solmaz Abdolrahimzadeh ◽  
Mariachiara Di Pippo ◽  
Edoardo Sordi ◽  
Sandrine Anne Zweifel
Keyword(s):  
Layer Thickness ◽  
Near Infrared ◽  
Age Related Macular Degeneration ◽  
Analysis Of Covariance ◽  
Retinal Layer ◽  
Continuous Variables ◽  
Near Infrared Reflectance ◽  
Age Related ◽  
Cd 68 ◽  
Subretinal Drusenoid Deposits

The purpose of this study was to evaluate central and parafoveal inner retinal layer thickness in patients with subretinal drusenoid deposits (SDD) or conventional drusen (CD). Participants underwent comprehensive ophthalmoscopic examination. Evidence of SDD or CD was evaluated with near infrared reflectance and spectral domain optical coherence tomography. Quantification of subfoveal lesions was made through a qualitative analysis of vertical and horizontal SD-OCT scans centered on the fovea. Inner retinal layer macular thickness measurements were obtained for central circles with 1, 3, and 5 mm diameter. Continuous variables were compared by the analysis of covariance (ANCOVA) with post-hoc Tukey HSD correction for multiple comparison analysis. Fifty-five patients were included in the study; 18 eyes with SDD alone, 19 eyes with CD alone, and 18 eyes of healthy age-matched subjects. Eight eyes with SDD (44%) and 13 eyes with CD (68%) had subfoveal lesions. There was significant reduction in the inner retinal layer thickness in the central 1mm area and in the superior 3 mm area in the SDD and CD group compared to controls. In conclusion the inner retinal layer is thinner in the central macula and in the superior parafovea in eyes.

Near-infrared fundus autofluorescence in early age-related macular degeneration

2019 ◽  
Vol 30 (6) ◽  
pp. 1448-1453
Author(s):  
Maurizio Battaglia Parodi ◽  
Pierluigi Iacono ◽  
Alexandros Papayannis ◽  
Giorgio Alto ◽  
Alessio Buzzotta ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Macular Degeneration ◽  
Short Wavelength ◽  
Near Infrared ◽  
Fundus Autofluorescence ◽  
Age Related Macular Degeneration ◽  
Early Age ◽  
Corrected Visual Acuity ◽  
Age Related ◽  
Best Corrected Visual Acuity

Purpose: To describe the patterns on near-infrared fundus autofluorescence in eyes affected by early age-related macular degeneration. Design: Cross-sectional observational case series. Participants: A total of 84 eyes of 84 patients suffering from early age-related macular degeneration (>63 μm but <125 μm drusen and no-to-mild retinal pigment epithelium abnormalities) were enrolled. Methods: Patients underwent best-corrected visual acuity, biomicroscopy, infrared reflectance, short-wavelength fundus autofluorescence, and near-infrared fundus autofluorescence. Eyes were classified according to different patterns of near-infrared fundus autofluorescence. Main outcome was definition of relative prevalence and features of each near-infrared fundus autofluorescence pattern; secondary outcomes were correlation between near-infrared fundus autofluorescence and short-wavelength fundus autofluorescence and between near-infrared fundus autofluorescence patterns and best-corrected visual acuity. Results: Four different patterns of near-infrared fundus autofluorescence identified: normal foveal signal (Pattern A, 7%); normal foveal signal with hyperautofluorescent/hypoautofluorescent spots not involving the fovea (Pattern B, 65.5%); hyperautofluorescent/hypoautofluorescent spots involving the fovea (Pattern C, 15.5%); patchy pattern (Pattern D, 12%). best-corrected visual acuity was lower in eyes with foveal signal alteration (Patterns C and D). Conclusion: Near-infrared fundus autofluorescence pattern in early age-related macular degeneration might be suggestive of visual function deterioration when the fovea is involved. Longitudinal studies are warranted to confirm our preliminary results.

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